VivoSim Labs (FRA:4OR) Owner Earnings per Share (TTM): -2.34 (As of Dec. 2025)


FRA:4OR VivoSim Labs Inc FRA:4OR
38 GF Score
Price €3.49
GF Value €9.41
! 4 Warning Signs
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What is VivoSim Labs Owner Earnings per Share (TTM)?

VivoSim Labs FRA:4OR 38 Owner Earnings per Share (TTM) is -2.34 as of Dec. 2025. GuruFocus rates FRA:4OR with a GF Score™ of 38/100 and a GF Value™ of €9.41. The stock has 4 warning signs investors should review. Among 206 Biotechnology companies, VivoSim Labs ranks worse than 485436.41% on this metric.

In 1986 Berkshire Hathaway Shareholder Letter, Warren Buffett defined owner earnings as follows:

"These represent (a) reported earnings plus (b) depreciation, depletion, amortization, and certain other non-cash charges...less (c) the average annual amount of capitalized expenditures for plant and equipment, etc. that the business requires to fully maintain its long-term competitive position and its unit volume (If the business requires additional working capital to maintain its competitive position and unit volume, the increment also should be included in (c))...Our owner-earnings equation does not yield the deceptively precise figures provided by GAAP, since (c) must be a guess - and one sometimes very difficult to make. Despite this problem, we consider the owner earnings figure, not the GAAP figure, to be the relevant item for valuation purposes - both for investors in buying stocks and for managers in buying entire businesses...All of this points up the absurdity of the 'cash flow' numbers that are often set forth in Wall Street reports. These numbers routinely include (a) plus (b) - but do not subtract (c)."

VivoSim Labs's Owner Earnings per Share (TTM) ended in Dec. 2025 was €-2.34. It's Price-to-Owner-Earnings ratio for today is 0.


The historical rank and industry rank for VivoSim Labs's Owner Earnings per Share (TTM) or its related term are showing as below:



FRA:4OR's Price-to-Owner-Earnings is not ranked *
in the Biotechnology industry.
Industry Median: 25.615
* Ranked among companies with meaningful Price-to-Owner-Earnings only.

VivoSim Labs's Earnings per Share (Diluted) for the three months ended in Dec. 2025 was €-0.88. Its Earnings per Share (Diluted) for the trailing twelve months (TTM) ended in Dec. 2025 was €1.83. It's PE Ratio (TTM) ratio for today is 1.91.

VivoSim Labs's EPS without NRI for the three months ended in Dec. 2025 was €-0.88. Its EPS without NRI for the trailing twelve months (TTM) ended in Dec. 2025 was €1.83. It's PE Ratio without NRI ratio for today is 1.91.


Be Aware

Assumption: Companies usually do not report maintenance capital expenditures and growth capital expenditures separately. Here we use estimated numbers and average them over 5 years. The method to estimate maintenance capital expenditures can be found in above part 4.

Note: GuruFocus' Change In Working Capital is provided by Morningstar. It is calculated by adding the items under "Change in operating assets and liabilities" (may refer to a different name for different company) section in Cash Flow Statement from original financial report. And it includes non-current parts of assets and liabilities.


VivoSim Labs Owner Earnings per Share (TTM) Related Terms


VivoSim Labs Owner Earnings per Share (TTM) Historical Data

* Premium members only.

The historical data trend for VivoSim Labs's Owner Earnings per Share (TTM) can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

VivoSim Labs Owner Earnings per Share (TTM) Chart

VivoSim Labs Annual Data
Trend Mar16 Mar17 Mar18 Mar19 Mar20 Mar21 Mar22 Mar23 Mar24 Mar25
Owner Earnings per Share (TTM)
Get a 7-Day Free Trial Premium Member Only Premium Member Only -25.98 -13.34 -19.58 -18.17 -1.46

VivoSim Labs Quarterly Data
Mar21 Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25
Owner Earnings per Share (TTM) Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -6.89 -1.46 -2.30 -0.89 -1.27

FRA:4OR vs SLXN, CDT, CLDI: Owner Earnings per Share (TTM) Comparison

For the Biotechnology subindustry, VivoSim Labs's Price-to-Owner-Earnings, along with its competitors' market caps and Price-to-Owner-Earnings data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


VivoSim Labs Price-to-Owner-Earnings vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, VivoSim Labs's Price-to-Owner-Earnings distribution charts can be found below:

* The bar in red indicates where VivoSim Labs's Price-to-Owner-Earnings falls into.


FRA:4OR
38GF Score
VivoSim Labs Inc FRA:4OR
Owner Earnings per Share (TTM) is just one metric. See GF Score™, valuation, warning signs, and more.
View Full Analysis

VivoSim Labs Owner Earnings per Share (TTM) Calculation

In 1986 Berkshire Hathaway Shareholder Letter, Warren Buffett defined owner earnings as follows:

"These represent (a) reported earnings plus (b) depreciation, depletion, amortization, and certain other non-cash charges...less (c) the average annual amount of capitalized expenditures for plant and equipment, etc. that the business requires to fully maintain its long-term competitive position and its unit volume. (If the business requires additional working capital to maintain its competitive position and unit volume, the increment also should be included in (c))...Our owner-earnings equation does not yield the deceptively precise figures provided by GAAP, since (c) must be a guess - and one sometimes very difficult to make. Despite this problem, we consider the owner earnings figure, not the GAAP figure, to be the relevant item for valuation purposes - both for investors in buying stocks and for managers in buying entire businesses...All of this points up the absurdity of the 'cash flow' numbers that are often set forth in Wall Street reports. These numbers routinely include (a) plus (b) - but do not subtract (c)."

To make it simple, then you will have:

Owner Earnings per Share (TTM) = (Net Income + Depreciation, Depletion and Amortization + Change In Deferred Tax - 5Y Average of Maintenance Capital Expenditure + Change In Working Capital) / Shares Outstanding (Diluted Average)

VivoSim Labs's Owner Earnings per Share (TTM) Calculation:

TTM / Last Quarter Average of Last 20 Quarters
Net Income -0.59
Depreciation, Depletion and Amortization 0.20
Change In Deferred Tax 0.00
5Y Average of Maintenance Capital Expenditure 0.31
Change In Working Capital -0.28
Shares Outstanding (Diluted Average) 2.61

1. Start with "Net Income" from income statement. VivoSim Labs's Net Income for the trailing twelve months (TTM) ended in Dec. 2025 was €-0.59 Mil.

2. "Depreciation, Depletion and Amortization" is from cashflow statement. VivoSim Labs's Depreciation, Depletion and Amortization for the trailing twelve months (TTM) ended in Dec. 2025 was €0.20 Mil. This needs to be added back because company does not actually need to pay cash for it. It is a non-cash item.

3. Other non-cash charges usually include "Stock Based Compensation" and "Change In Deferred Tax":
However, to be conservative, GuruFocus will not add Stock Based Compensation back to net income. VivoSim Labs's Change In Deferred Tax for the trailing twelve months (TTM) ended in Dec. 2025 was €0.00 Mil.

4. Average maintenance capital expenditure over a business/industry cycle: 5-Year Average Maintenance Capital Expenditure = €0.31 Mil

It is usually best to take a long-term average of maintenance capital expenditure. Ideally this would be as long as 10 years and include at least one economic downturn. However, since many companies do not have as long as 10-year history, here GuruFocus uses the latest 5 years data to do the calculation. To smooth out unusual years but reflect recent developments, we take an average of the 5 year maintenance capital expenditure.

The following shows how to get maintenance capital expenditure.

First, calculate the revenue change regarding to the previous quarter. If the revenue decreased from the previous quarter, then the Maintenance Capital Expenditure = Capital Expenditure (positive).
Second, if the revenue increased from the previous quarter, then calculate the percentage of Net PPE as of corresponding Revenue.
Growth Capital Expenditure = Percentage of Property, Plant and Equipment as of corresponding Revenue * Revenue Increase
Third, calculate Capital Expenditure (positive) - Growth Capital Expenditure.
If [Capital Expenditure (positive) - Growth Capital Expenditure] was negative, then the Maintenance Capital Expenditure = Capital Expenditure (positive).
If [Capital Expenditure (positive) - Growth Capital Expenditure] was positive, then the Maintenance Capital Expenditure = Capital Expenditure (positive) - Growth Capital Expenditure.
Fourth, get the average of the 5 years maintenance capital expenditure.

VivoSim Labs's 5-Year Average Maintenance Capital Expenditure = €0.31 Mil

5. "Change In Working Capital" is from cashflow statement. VivoSim Labs's Change In Working Capital for the trailing twelve months (TTM) ended in Dec. 2025 was €-0.28 Mil.
Note: GuruFocus' Change in Working Capital is provided by Morningstar. It is calculated by adding the items under "Change in operating assets and liabilities" (may refer to a different name for different company) section in Cash Flow Statement from original financial report. And sometimes it includes non-current parts of assets and liabilities.

6. VivoSim Labs's Shares Outstanding (Diluted Average) for the months ended in Dec. 2025 was 2.608 Mil.

VivoSim Labs's Onwer Earnings Per Share for Dec. 2025 is calculated as:

Owner Earnings per Share (TTM)
=( Net Income+Depreciation, Depletion and Amortization+Change In Deferred Tax
=( -0.593 +0.203+0
-5Y Avg of Maintenance CAPEX+Change In Working Capital )/Shares Outstanding (Diluted Average)
-0.3084+-0.28)/2.608
=-2.34

Price-to-Owner-Earnings=Current Price/Owner Earnings per Share (TTM)
=3.492/-2.34
=0

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

What does a Owner Earnings per Share (TTM) of -2.34 mean?
VivoSim Labs (FRA:4OR) has a Owner Earnings per Share (TTM) of -2.34 as of Dec. 2025. Warren Buffett defined owner earnings as reported earnings plus depreciation less average maintenance capital expenditure. View historical data on VivoSim Labs. According to the industry distribution chart, VivoSim Labs ranks #999999 out of 206 companies in the Biotechnology industry.
Is VivoSim Labs' Owner Earnings per Share (TTM) too high?
VivoSim Labs' current Owner Earnings per Share (TTM) is -2.34. Based on the distribution chart, VivoSim Labs ranks #999999 out of 206 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, VivoSim Labs has a GF Score™ of 38/100, reflecting its overall financial health beyond just this single metric.
How does VivoSim Labs' Owner Earnings per Share (TTM) compare to SLXN and CDT?
According to the Biotechnology industry distribution chart, VivoSim Labs ranks #999999 out of 206 companies for Owner Earnings per Share (TTM). This places VivoSim Labs in the lower half of its industry. The industry median Owner Earnings per Share (TTM) is 25.62. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Owner Earnings per Share (TTM) for a Biotechnology company?
The median Owner Earnings per Share (TTM) among Biotechnology companies is 25.62, based on 206 companies in the industry. Companies in the top quartile (top 25%) have a Owner Earnings per Share (TTM) significantly above this median, while those in the bottom quartile fall well below. However, Owner Earnings per Share (TTM) should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Owner Earnings per Share (TTM) mean?
A high Owner Earnings per Share (TTM) can signal that a stock is expensive relative to its fundamentals. Warren Buffett defined owner earnings as reported earnings plus depreciation less average maintenance capital expenditure. View historical data on VivoSim Labs. For the Biotechnology industry, the median Owner Earnings per Share (TTM) is 25.62 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. VivoSim Labs's current Owner Earnings per Share (TTM) is -2.34. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is VivoSim Labs stock overvalued right now?
VivoSim Labs (FRA:4OR) has a current Owner Earnings per Share (TTM) of -2.34. The stock's GF Value™ is €9.41, compared to a current price of €3.49 — trading 62.9% below its estimated fair value. The current Owner Earnings per Share (TTM) is -2.34. VivoSim Labs' overall GF Score™ is 38/100 with 4 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Owner Earnings per Share (TTM) calculated?
Owner Earnings per Share (TTM) is calculated from a company's financial statements. For VivoSim Labs (FRA:4OR), the current Owner Earnings per Share (TTM) is -2.34 as of Dec. 2025. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is VivoSim Labs (FRA:4OR) Overvalued in 2026?

Based on GuruFocus' analysis, VivoSim Labs stock appears to be undervalued. The current stock price of €3.49 is trading 62.9% below its estimated GF Value™ of €9.41.

Key valuation signals for FRA:4OR:

  • Owner Earnings per Share (TTM): -2.34
  • GF Value™: €9.41 vs. price of €3.49 (62.9% below fair value)
  • GF Score™: 38/100 with 4 warning signs

No single metric tells the full story. See the FRA:4OR stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


VivoSim Labs Business Description

Other Exchanges VIVS:USA
Address 11555 Sorrento Valley road, Suite 100, San Diego, CA, USA, 92121
VivoSim Labs Inc formerly, Organovo Holdings Inc is a biotechnology company focused on developing FXR314 in inflammatory bowel disease (IBD), including ulcerative colitis (UC), based on demonstration of clinical promise in three-dimensional (3D) human tissues as well as preclinical data. FXR is a mediator of gastrointestinal and liver diseases. It is now offering liver toxicology predictive screening and research services as well as working on predicting and studying the intestinal side effect profiles of drugs that are therapeutic candidates of pharmaceutical and biotech companies at all stages of drug development.
38GF Score

Get the complete analysis for FRA:4OR

Owner Earnings per Share (TTM) is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

€3.49
Price
€9.41
GF Value