PRAX (Praxis Precision Medicines) PE Ratio: At Loss (As of Jun. 25, 2026)


PRAX Praxis Precision Medicines Inc PRAX
38 GF Score
Price $327.26
GF Value $30.36
Valuation Significantly Overvalued
! 1 Warning Sign
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What is Praxis Precision Medicines PE Ratio?

The PE Ratio, or Price-to-Earnings ratio, or P/E Ratio, is a financial ratio used to compare a company's market price to its Earnings per Share (Diluted). As of today (2026-06-25), Praxis Precision Medicines's share price is $327.26. Praxis Precision Medicines's Earnings per Share (Diluted) for the trailing twelve months (TTM) ended in Mar. 2026 was $-13.37. Therefore, Praxis Precision Medicines's PE Ratio for today is At Loss.

Praxis Precision Medicines's EPS (Diluted) for the three months ended in Mar. 2026 was $-3.20. Its EPS (Diluted) for the trailing twelve months (TTM) ended in Mar. 2026 was $-13.37.

As of today (2026-06-25), Praxis Precision Medicines's share price is $327.26. Praxis Precision Medicines's EPS without NRI for the trailing twelve months (TTM) ended in Mar. 2026 was $-13.37. Therefore, Praxis Precision Medicines's PE Ratio without NRI ratio for today is At Loss.

Praxis Precision Medicines's EPS without NRI for the three months ended in Mar. 2026 was $-3.20. Its EPS without NRI for the trailing twelve months (TTM) ended in Mar. 2026 was $-13.37.

During the past 3 years, the average EPS without NRI Growth Rate was 42.20% per year. During the past 5 years, the average EPS without NRI Growth Rate was 39.20% per year.

During the past 8 years, Praxis Precision Medicines's highest 3-Year average EPS without NRI Growth Rate was 45.90% per year. The lowest was -31.00% per year. And the median was 42.20% per year.

Praxis Precision Medicines's EPS (Basic) for the three months ended in Mar. 2026 was $-3.20. Its EPS (Basic) for the trailing twelve months (TTM) ended in Mar. 2026 was $-13.37.

Back to Basics: PE Ratio


Praxis Precision Medicines  (NAS:PRAX) PE Ratio Explanation

The PE Ratio can be viewed as the number of years it takes for the company to earn back the price you pay for the stock. For example, if a company earns $2 a share per year, and the stock is traded at $30, the PE Ratio is 15. Therefore it takes 15 years for the company to earn back the $30 you paid for its stock, assuming the earnings stays constant over the next 15 years.

In real business, earnings never stay constant. If a company can grow its earnings, it takes fewer years for the company to earn back the price you pay for the stock. If a company's earnings decline it takes more years. As a shareholder, you want the company to earn back the price you pay as soon as possible. Therefore, lower P/E stocks are more attractive than higher P/E stocks so long as the PE Ratio is positive. Also for stocks with the same PE Ratio, the one with faster growth business is more attractive.

If a company loses money, the PE Ratio becomes meaningless.

To compare stocks with different growth rates, Peter Lynch invented a ratio called PEG Ratio. PEG Ratio is defined as the PE Ratio divided by the growth ratio. He thinks a company with a PE Ratio equal to its growth rate is fairly valued. Still he said he would rather buy a company growing 20% a year with a PE Ratio of 20, instead of a company growing 10% a year with a PE Ratio of 10.

Because the PE Ratio measures how long it takes to earn back the price you pay, the PE Ratio can be applied to the stocks across different industries. That is why it is the one of the most important and widely used indicators for the valuation of stocks.

Similar to the PE Ratio without NRI or PS Ratio or Price-to-Operating-Cash-Flow or Price-to-Free-Cash-Flow , the PE Ratio measures the valuation based on the earning power of the company. This is where it is different from the PB Ratio , which measures the valuation based on the company's balance sheet.


Be Aware

Investors need to be aware that the PE Ratio can be misleading a lot of times, especially when the underlying business is cyclical and unpredictable. As Peter Lynch pointed out, cyclical businesses have higher profit margins at the peaks of the business cycles. Their earnings are high and PE Ratios are artificially low. It is usually a bad idea to buy a cyclical business when the PE Ratio is low. A better ratio to identify the time to buy a cyclical businesses is the PS Ratio.

PE Ratio can also be affected by non-recurring-items such as the sale of part of businesses. This may increase for the current year or quarter dramatically. But it cannot be repeated over and over. Therefore PE Ratio without NRI is a more accurate indication of valuation than PE Ratio.


Praxis Precision Medicines PE Ratio Related Terms


Praxis Precision Medicines PE Ratio Historical Data

* Premium members only.

The historical data trend for Praxis Precision Medicines's PE Ratio can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Praxis Precision Medicines PE Ratio Chart

Praxis Precision Medicines Annual Data
Trend Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
PE Ratio
Get a 7-Day Free Trial At Loss At Loss At Loss At Loss At Loss

Praxis Precision Medicines Quarterly Data
Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
PE Ratio Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only At Loss At Loss At Loss At Loss At Loss

PRAX vs KRYS, CYTK, NUVL: PE Ratio Comparison

For the Biotechnology subindustry, Praxis Precision Medicines's PE Ratio, along with its competitors' market caps and PE Ratio data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Praxis Precision Medicines PE Ratio vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Praxis Precision Medicines's PE Ratio distribution charts can be found below:

* The bar in red indicates where Praxis Precision Medicines's PE Ratio falls into.


PRAX
38GF Score
Praxis Precision Medicines Inc PRAX
PE Ratio is just one metric. See GF Score™, valuation, warning signs, and more.
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Praxis Precision Medicines PE Ratio Calculation

The PE Ratio, or Price-to-Earnings ratio, or P/E Ratio, is a financial ratio used to compare a company's market price to its Earnings per Share (Diluted). It is the most widely used ratio in the valuation of stocks.

Praxis Precision Medicines's PE Ratio for today is calculated as

PE Ratio=Share Price/Earnings per Share (Diluted) (TTM)
=327.26/-13.370
=-24.48(At Loss)

Praxis Precision Medicines's Share Price of today is $327.26.
Praxis Precision Medicines's Earnings per Share (Diluted) for the trailing twelve months (TTM) ended in Mar. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was $-13.37.


* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

It can also be calculated from the numbers for the whole company:


There are at least three kinds of PE Ratios used by different investors. They are Trailing Twelve Month PE Ratio, Forward PE Ratio, or PE Ratio without NRI. A new PE Ratio based on inflation-adjusted normalized PE Ratio is called Shiller PE Ratio, after Yale professor Robert Shiller.

In the calculation of PE Ratio, the earnings per share used are the earnings per share over the past 12 months. For Forward PE Ratio, the earnings are the expected earnings for the next twelve months. In the case of PE Ratio without NRI, the reported earnings less the non-recurring items are used.

For Shiller PE Ratio, the earnings of the past 10 years are inflation-adjusted and averaged. Since it looks at the average over the last 10 years, Shiller PE Ratio is also called PE10.

Is Praxis Precision Medicines (PRAX) Overvalued in 2026?

Based on GuruFocus' analysis, Praxis Precision Medicines stock appears to be overvalued. The current stock price of $327.26 is trading 977.9% above its estimated GF Value™ of $30.36. GuruFocus considers Praxis Precision Medicines to be Significantly Overvalued.

Key valuation signals for PRAX:

  • PE Ratio: At Loss
  • GF Value™: $30.36 vs. price of $327.26 (977.9% above fair value)
  • GF Score™: 38/100 with 1 warning sign

No single metric tells the full story. See the PRAX stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


Praxis Precision Medicines Business Description

Address 99 High Street, 30th Floor, Boston, MA, USA, 02110
Praxis Precision Medicines Inc is a clinical-stage biopharmaceutical company. It is engaged in translating genetic insights into the development of therapies for patients affected by central nervous system disorders characterized by a neuronal excitation-inhibition imbalance. The company applies genetic insights to the discovery and development of therapies for neurological disorders through two proprietary platforms: Cerebrum and Solidus. It has established a diversified, multimodal CNS portfolio with four clinical-stage product candidates across movement disorders and epilepsy, which include Ulixacaltamide, Relutrigine, Vormatrigine, and Elsunersen. The firm operates in only one segment and is focused on discovering and developing therapies for CNS disorders.
38GF Score

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PE Ratio is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

$327.26
Price
$30.36
GF Value