ENSCW (Ensysce Biosciences) Return-on-Tangible-Equity: -989.84% (As of Mar. 2026)


ENSCW Ensysce Biosciences Inc ENSCW
23 GF Score
Price $0.00
! 2 Warning Signs
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What is Ensysce Biosciences Return-on-Tangible-Equity?

Ensysce Biosciences ENSCW 23 Return-on-Tangible-Equity is -989.84% as of Mar. 2026. GuruFocus rates ENSCW with a GF Score™ of 23/100. The stock has 2 warning signs investors should review. Among 1,200 Biotechnology companies, Ensysce Biosciences ranks worse than 95.33% on this metric.

Return-on-Tangible-Equity is calculated as Net Income divided by its average total shareholder tangible equity. Total shareholder tangible equity equals to Total Stockholders Equity minus Intangible Assets. Ensysce Biosciences's annualized net income for the quarter that ended in Mar. 2026 was $-14.22 Mil. Ensysce Biosciences's average shareholder tangible equity for the quarter that ended in Mar. 2026 was $1.44 Mil. Therefore, Ensysce Biosciences's annualized Return-on-Tangible-Equity for the quarter that ended in Mar. 2026 was -989.84%.

The historical rank and industry rank for Ensysce Biosciences's Return-on-Tangible-Equity or its related term are showing as below:

ENSCW' s Return-on-Tangible-Equity Range Over the Past 10 Years
Min: -560.44   Med: -382.97   Max: -294.02
Current: -560.44

During the past 6 years, Ensysce Biosciences's highest Return-on-Tangible-Equity was -294.02%. The lowest was -560.44%. And the median was -382.97%.

ENSCW's Return-on-Tangible-Equity is ranked worse than
95.33% of 1200 companies
in the Biotechnology industry
Industry Median: -42.435 vs ENSCW: -560.44

Ensysce Biosciences  (OTCPK:ENSCW) Return-on-Tangible-Equity Explanation

Return-on-Tangible-Equity measures the rate of return on the ownership interest (shareholder's tangible equity) of the common stock owners. It measures a firm's efficiency at generating profits from every unit of shareholders' tangible equity (shareholders equity minus intangibles). Return-on-Tangible-Equity shows how well a company uses investment funds to generate earnings growth. Return-on-Tangible-Equitys between 15% and 20% are considered desirable.


Be Aware

Net Income is used.

Because a company can increase its Return-on-Tangible-Equity by having more financial leverage, it is important to watch the leverage ratio when investing in high Return-on-Tangible-Equity companies. Like Return-on-Tangible-Asset, Return-on-Tangible-Equity is calculated with only 12 months data. Fluctuations in company's earnings or business cycles can affect the ratio drastically. It is important to look at the ratio from a long term perspective.

Asset light businesses require very few assets to generate very high earnings. Their Return-on-Tangible-Equitys can be extremely high.


Ensysce Biosciences Return-on-Tangible-Equity Related Terms


Ensysce Biosciences Return-on-Tangible-Equity Historical Data

* Premium members only.

The historical data trend for Ensysce Biosciences's Return-on-Tangible-Equity can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Ensysce Biosciences Return-on-Tangible-Equity Chart

Ensysce Biosciences Annual Data
Trend Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
Return-on-Tangible-Equity
Get a 7-Day Free Trial 0.00 0.00 0.00 -471.91 -294.02

Ensysce Biosciences Quarterly Data
Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
Return-on-Tangible-Equity Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -230.40 -215.35 -649.65 -501.34 -989.84

ENSCW vs RNAZ, ALZN, CELZ: Return-on-Tangible-Equity Comparison

For the Biotechnology subindustry, Ensysce Biosciences's Return-on-Tangible-Equity, along with its competitors' market caps and Return-on-Tangible-Equity data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Ensysce Biosciences Return-on-Tangible-Equity vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Ensysce Biosciences's Return-on-Tangible-Equity distribution charts can be found below:

* The bar in red indicates where Ensysce Biosciences's Return-on-Tangible-Equity falls into.


ENSCW
23GF Score
Ensysce Biosciences Inc ENSCW
Return-on-Tangible-Equity is just one metric. See GF Score™, valuation, warning signs, and more.
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Ensysce Biosciences Return-on-Tangible-Equity Calculation

Ensysce Biosciences's annualized Return-on-Tangible-Equity for the fiscal year that ended in Dec. 2025 is calculated as

Return-on-Tangible-Equity=Net Income/( (Total Tangible Equity+Total Tangible Equity)/ count )
(A: Dec. 2025 )  (A: Dec. 2024 )(A: Dec. 2025 )
=Net Income/( (Total Stockholders Equity - Intangible Assets+Total Stockholders Equity - Intangible Assets )/ count )
(A: Dec. 2025 )  (A: Dec. 2024 )(A: Dec. 2025 )
=-10.176/( (3.708+3.214 )/ 2 )
=-10.176/3.461
=-294.02 %

Ensysce Biosciences's annualized Return-on-Tangible-Equity for the quarter that ended in Mar. 2026 is calculated as

Return-on-Tangible-Equity=Net Income/( (Total Tangible Equity+Total Tangible Equity)/ count )
(Q: Mar. 2026 )  (Q: Dec. 2025 )(Q: Mar. 2026 )
=Net Income/( (Total Stockholders Equity - Intangible Assets+Total Stockholders Equity - Intangible Assets)/ count )
(Q: Mar. 2026 )  (Q: Dec. 2025 )(Q: Mar. 2026 )
=-14.224/( (3.214+-0.34)/ 2 )
=-14.224/1.437
=-989.84 %

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

In the calculation of annual Return-on-Tangible-Equity, the net income of the last fiscal year and the average total shareholder tangible equity over the fiscal year are used. In calculating the quarterly data, the net income data used here is four times the quarterly (Mar. 2026) net income data. Return-on-Tangible-Equity is displayed in the 10-year financial page.

What does a Return-on-Tangible-Equity of -989.84% mean?
Ensysce Biosciences (ENSCW) has a Return-on-Tangible-Equity of -989.84% as of Mar. 2026. Return on tangible equity is the ratio of current-period net income to average two-period tangible equity. View historical data on Ensysce Biosciences and its competitors. According to the industry distribution chart, Ensysce Biosciences ranks #1144 out of 1200 companies in the Biotechnology industry, placing it in the top 95.3%.
Is Ensysce Biosciences' Return-on-Tangible-Equity too high?
Ensysce Biosciences' current Return-on-Tangible-Equity is -989.84%. Based on the distribution chart, Ensysce Biosciences ranks #1144 out of 1200 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, Ensysce Biosciences has a GF Score™ of 23/100, reflecting its overall financial health beyond just this single metric.
How does Ensysce Biosciences' Return-on-Tangible-Equity compare to RNAZ and ALZN?
According to the Biotechnology industry distribution chart, Ensysce Biosciences ranks #1144 out of 1200 companies for Return-on-Tangible-Equity. This places Ensysce Biosciences in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Return-on-Tangible-Equity for a Biotechnology company?
A good Return-on-Tangible-Equity depends on the Biotechnology industry context. However, Return-on-Tangible-Equity should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Return-on-Tangible-Equity mean?
A high Return-on-Tangible-Equity can signal that a stock is expensive relative to its fundamentals. Return on tangible equity is the ratio of current-period net income to average two-period tangible equity. View historical data on Ensysce Biosciences and its competitors. Ensysce Biosciences's current Return-on-Tangible-Equity is -989.84%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Ensysce Biosciences stock overvalued right now?
Ensysce Biosciences (ENSCW) has a current Return-on-Tangible-Equity of -989.84%. The current Return-on-Tangible-Equity is -989.84%. Ensysce Biosciences' overall GF Score™ is 23/100 with 2 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Return-on-Tangible-Equity calculated?
Return-on-Tangible-Equity is calculated from a company's financial statements. For Ensysce Biosciences (ENSCW), the current Return-on-Tangible-Equity is -989.84% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Ensysce Biosciences Business Description

Other Exchanges ENSC:USA
Address 7946 Ivanhoe Avenue, Suite 201, La Jolla, CA, USA, 92037
Ensysce Biosciences Inc is a clinical-stage biotech company using its proprietary technology platforms to develop safer prescription drugs. The company is developing a new class of powerful, opioids that prevent both drug abuse and overdoses. Its products are anticipated to provide safer options to treat severe pain and assist in preventing deaths caused by opioid abuse, reducing human and economic costs. The company's current development pipeline includes two new drug platforms: an abuse-resistant opioid prodrug technology, theTrypsin Activated Abuse Protection, or the TAAP platform, and an over-dose protection opioid prodrug technology, the Multi-Pill Abuse Resistant, or the MPAR platform. The Company currently operates in one business segment, which is pharmaceuticals.
23GF Score

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