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Shattuck LabsSTTK +4.80%42 Return-on-Tangible-Equity is -66.28% as of Mar. 2026. GuruFocus rates STTK with a GF Score™ of 42/100 and a GF Value™ of $1.05 (Significantly Overvalued). The stock has 6 warning signs investors should review. Among 1,200 Biotechnology companies, Shattuck Labs ranks worse than 60.58% on this metric.
Return-on-Tangible-Equity is calculated as Net Income divided by its average total shareholder tangible equity. Total shareholder tangible equity equals to Total Stockholders Equity minus Intangible Assets. Shattuck Labs's annualized net income for the quarter that ended in Mar. 2026 was $-59.07 Mil. Shattuck Labs's average shareholder tangible equity for the quarter that ended in Mar. 2026 was $89.11 Mil. Therefore, Shattuck Labs's annualized Return-on-Tangible-Equity for the quarter that ended in Mar. 2026 was -66.28%.
The historical rank and industry rank for Shattuck Labs's Return-on-Tangible-Equity or its related term are showing as below:
STTK'
s Return-on-Tangible-Equity Range Over the Past 10 Years
Min: -67.23 Med: -49.97 Max: -15.46
Current: -62.96
During the past 8 years, Shattuck Labs's highest Return-on-Tangible-Equity was -15.46%. The lowest was -67.23%. And the median was -49.97%.
STTK's Return-on-Tangible-Equity is ranked worse than 60.58% of 1200
companies
in the Biotechnology industry
Industry Median: -42.305
vs STTK: -62.96
Return-on-Tangible-Equity measures the rate of return on the ownership interest (shareholder's tangible equity) of the common stock owners. It measures a firm's efficiency at generating profits from every unit of shareholders' tangible equity (shareholders equity minus intangibles). Return-on-Tangible-Equity shows how well a company uses investment funds to generate earnings growth. Return-on-Tangible-Equitys between 15% and 20% are considered desirable.
Be Aware
Net Income is used.
Because a company can increase its Return-on-Tangible-Equity by having more financial leverage, it is important to watch the leverage ratio when investing in high Return-on-Tangible-Equity companies. Like Return-on-Tangible-Asset, Return-on-Tangible-Equity is calculated with only 12 months data. Fluctuations in company's earnings or business cycles can affect the ratio drastically. It is important to look at the ratio from a long term perspective.
Asset light businesses require very few assets to generate very high earnings. Their Return-on-Tangible-Equitys can be extremely high.
Shattuck Labs Return-on-Tangible-Equity Related Terms
Shattuck Labs Return-on-Tangible-Equity Historical Data
* Premium members only.
The historical data trend for Shattuck Labs's Return-on-Tangible-Equity can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
STTK vs ACHV, CRMD, EIKN: Return-on-Tangible-Equity Comparison
For the Biotechnology subindustry, Shattuck Labs's Return-on-Tangible-Equity, along with its competitors' market caps and Return-on-Tangible-Equity data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Shattuck Labs Return-on-Tangible-Equity vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Shattuck Labs's Return-on-Tangible-Equity distribution charts can be found below:
* The bar in red indicates where Shattuck Labs's Return-on-Tangible-Equity falls into.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
In the calculation of annual Return-on-Tangible-Equity, the net income of the last fiscal year and the average total shareholder tangible equity over the fiscal year are used. In calculating the quarterly data,
the net income data used here is four times the quarterly (Mar. 2026) net income data.
Return-on-Tangible-Equity is displayed in the 10-year financial page.
What does a Return-on-Tangible-Equity of -66.28% mean?
Shattuck Labs (STTK) has a Return-on-Tangible-Equity of -66.28% as of Mar. 2026. Return on tangible equity is the ratio of current-period net income to average two-period tangible equity. View historical data on Shattuck Labs and its competitors. According to the industry distribution chart, Shattuck Labs ranks #727 out of 1200 companies in the Biotechnology industry, placing it in the top 60.6%.
Is Shattuck Labs' Return-on-Tangible-Equity too high?
Shattuck Labs' current Return-on-Tangible-Equity is -66.28%. Based on the distribution chart, Shattuck Labs ranks #727 out of 1200 companies in the Biotechnology industry, which is below the industry midpoint. Overall, Shattuck Labs has a GF Score™ of 42/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Shattuck Labs' Return-on-Tangible-Equity compare to ACHV and CRMD?
According to the Biotechnology industry distribution chart, Shattuck Labs ranks #727 out of 1200 companies for Return-on-Tangible-Equity. This places Shattuck Labs in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Return-on-Tangible-Equity for a Biotechnology company?
A good Return-on-Tangible-Equity depends on the Biotechnology industry context. However, Return-on-Tangible-Equity should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Return-on-Tangible-Equity mean?
A high Return-on-Tangible-Equity can signal that a stock is expensive relative to its fundamentals. Return on tangible equity is the ratio of current-period net income to average two-period tangible equity. View historical data on Shattuck Labs and its competitors. Shattuck Labs's current Return-on-Tangible-Equity is -66.28%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Shattuck Labs stock overvalued right now?
Based on GuruFocus' analysis, Shattuck Labs (STTK) is currently considered Significantly Overvalued. The stock's GF Value™ is $1.05, compared to a current price of $7.42 — trading 606.7% above its estimated fair value. The current Return-on-Tangible-Equity is -66.28%. Shattuck Labs' overall GF Score™ is 42/100 with 6 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Return-on-Tangible-Equity calculated?
Return-on-Tangible-Equity is calculated from a company's financial statements. For Shattuck Labs (STTK), the current Return-on-Tangible-Equity is -66.28% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is Shattuck Labs (STTK) Overvalued in 2026?
Based on GuruFocus' analysis, Shattuck Labs stock appears to be overvalued.
The current stock price of $7.42 is trading 606.7% above its estimated GF Value™ of $1.05.
GuruFocus considers Shattuck Labs to be Significantly Overvalued.
Key valuation signals for STTK:
Return-on-Tangible-Equity: -66.28%
GF Value™: $1.05 vs. price of $7.42 (606.7% above fair value)
No single metric tells the full story. See the STTK stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
Shattuck Labs Inc is a biotechnology company specializing in the development of potential treatments for inflammatory and immune-mediated diseases. It is developing a potentially first-in-class antibody for the treatment of inflammatory bowel disease (IBD) and other inflammatory and immune-mediated diseases. The company's expertise in protein engineering and the development of novel tumor necrosis factor (TNF) receptor therapeutics comes together in its main program, SL-325, which has the potential to be a first-in-class death receptor 3 (DR3) antagonist antibody. In addition, the company is developing SL-425, a half-life extended version of SL-325, and multiple other preclinical DR3-based bispecific antibodies, for the treatment of patients with IBD.
42GF Score
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