SHPH (Shuttle Pharmaceuticals Holdings) ROA %: -77.25% (As of Mar. 2026)


SHPH Shuttle Pharmaceuticals Holdings Inc SHPH
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What is Shuttle Pharmaceuticals Holdings ROA %?

Shuttle Pharmaceuticals Holdings SHPH +6.35% 24 ROA % is -77.25% as of Mar. 2026. GuruFocus rates SHPH with a GF Score™ of 24/100. The stock has 1 warning sign investors should review. Among 1,006 Drug Manufacturers companies, Shuttle Pharmaceuticals Holdings ranks worse than 96.42% on this metric.

ROA % is calculated as Net Income divided by its average Total Assets over a certain period of time. Shuttle Pharmaceuticals Holdings's annualized Net Income for the quarter that ended in Mar. 2026 was $-8.61 Mil. Shuttle Pharmaceuticals Holdings's average Total Assets over the quarter that ended in Mar. 2026 was $11.14 Mil. Therefore, Shuttle Pharmaceuticals Holdings's annualized ROA % for the quarter that ended in Mar. 2026 was -77.25%.

The historical rank and industry rank for Shuttle Pharmaceuticals Holdings's ROA % or its related term are showing as below:

SHPH' s ROA % Range Over the Past 10 Years
Min: -216.24   Med: -164.38   Max: -90.28
Current: -147.64

During the past 6 years, Shuttle Pharmaceuticals Holdings's highest ROA % was -90.28%. The lowest was -216.24%. And the median was -164.38%.

SHPH's ROA % is ranked worse than
96.42% of 1006 companies
in the Drug Manufacturers industry
Industry Median: 2.685 vs SHPH: -147.64

Shuttle Pharmaceuticals Holdings  (NAS:SHPH) ROA % Explanation

ROA % measures the rate of return on the total assets (shareholder equity plus liabilities). It measures a firm's efficiency at generating profits from shareholders' equity plus its liabilities. ROA % shows how well a company uses what it has to generate earnings. ROA %s can vary drastically across industries. Therefore, ROA % should not be used to compare companies in different industries. For retailers, a ROA % of higher than 5% is expected. For example, Wal-Mart (WMT) has a ROA % of about 8% as of 2012. For banks, ROA % is close to their interest spread. A bank’s ROA % is typically well under 2%.

Similar to ROE, ROA % is affected by profit margins and asset turnover. This can be seen from the Du Pont Formula:

ROA %(Q: Mar. 2026 )
=Net Income/Total Assets
=-8.608/11.1425
=(Net Income / Revenue)*(Revenue / Total Assets)
=(-8.608 / 0)*(0 / 11.1425)
=Net Margin %*Asset Turnover
=N/A %*0
=-77.25 %

Note: The Net Income data used here is four times the quarterly (Mar. 2026) net income data. The Revenue data used here is four times the quarterly (Mar. 2026) revenue data.

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.


Be Aware

Like ROE, ROA % is calculated with only 12 months data. Fluctuations in the company's earnings or business cycles can affect the ratio drastically. It is important to look at the ratio from a long term perspective. ROA % can be affected by events such as stock buyback or issuance, and by goodwill, a company's tax rate and its interest payment. ROA % may not reflect the true earning power of the assets. A more accurate measurement is ROC % (ROC).

Many analysts argue the higher return the better. Buffett states that really high ROA % may indicate vulnerability in the durability of the competitive advantage.

E.g. Raising $43b to take on KO is impossible, but $1.7b to take on Moody's is. Although Moody's ROA % and underlying economics is far superior to Coca Cola, the durability is far weaker because of lower entry cost.


Shuttle Pharmaceuticals Holdings ROA % Related Terms


Shuttle Pharmaceuticals Holdings ROA % Historical Data

* Premium members only.

The historical data trend for Shuttle Pharmaceuticals Holdings's ROA % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Shuttle Pharmaceuticals Holdings ROA % Chart

Shuttle Pharmaceuticals Holdings Annual Data
Trend Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
ROA %
Get a 7-Day Free Trial -192.64 -107.37 -90.28 -216.24 -180.59

Shuttle Pharmaceuticals Holdings Quarterly Data
Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
ROA % Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -312.49 -274.16 -207.54 -149.23 -77.25

SHPH vs PRFX, CBIH, UPC: ROA % Comparison

For the Drug Manufacturers - Specialty & Generic subindustry, Shuttle Pharmaceuticals Holdings's ROA %, along with its competitors' market caps and ROA % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Shuttle Pharmaceuticals Holdings ROA % vs Drug Manufacturers Industry

For the Drug Manufacturers industry and Healthcare sector, Shuttle Pharmaceuticals Holdings's ROA % distribution charts can be found below:

* The bar in red indicates where Shuttle Pharmaceuticals Holdings's ROA % falls into.


SHPH
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Shuttle Pharmaceuticals Holdings Inc SHPH
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Shuttle Pharmaceuticals Holdings ROA % Calculation

Shuttle Pharmaceuticals Holdings's annualized ROA % for the fiscal year that ended in Dec. 2025 is calculated as:

ROA %=Net Income (A: Dec. 2025 )/( (Total Assets (A: Dec. 2024 )+Total Assets (A: Dec. 2025 ))/ count )
=-11.722/( (2.506+10.476)/ 2 )
=-11.722/6.491
=-180.59 %

Shuttle Pharmaceuticals Holdings's annualized ROA % for the quarter that ended in Mar. 2026 is calculated as:

ROA %=Net Income (Q: Mar. 2026 )/( (Total Assets (Q: Dec. 2025 )+Total Assets (Q: Mar. 2026 ))/ count )
=-8.608/( (10.476+11.809)/ 2 )
=-8.608/11.1425
=-77.25 %

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

In the calculation of annual ROA %, the net income of the last fiscal year and the average total assets over the fiscal year are used. In calculating the quarterly data, the Net Income data used here is four times the quarterly (Mar. 2026) net income data. ROA % is displayed in the 30-year financial page.

Frequently Asked Questions Learn more about ROA % →
What does a ROA % of -77.25% mean?
Shuttle Pharmaceuticals Holdings (SHPH) has a ROA % of -77.25% as of Mar. 2026. Return on assets is the ratio of current-period net income to average two-period total assets. View historical data on Shuttle Pharmaceuticals Holdings and its competitors. According to the industry distribution chart, Shuttle Pharmaceuticals Holdings ranks #970 out of 1006 companies in the Drug Manufacturers industry, placing it in the top 96.4%.
Is Shuttle Pharmaceuticals Holdings' ROA % too high?
Shuttle Pharmaceuticals Holdings' current ROA % is -77.25%. Based on the distribution chart, Shuttle Pharmaceuticals Holdings ranks #970 out of 1006 companies in the Drug Manufacturers industry, which is in the bottom quartile relative to peers. Overall, Shuttle Pharmaceuticals Holdings has a GF Score™ of 24/100, reflecting its overall financial health beyond just this single metric.
How does Shuttle Pharmaceuticals Holdings' ROA % compare to PRFX and CBIH?
According to the Drug Manufacturers industry distribution chart, Shuttle Pharmaceuticals Holdings ranks #970 out of 1006 companies for ROA %. This places Shuttle Pharmaceuticals Holdings in the lower half of its industry. The industry median ROA % is 2.69. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good ROA % for a Drug Manufacturers company?
The median ROA % among Drug Manufacturers companies is 2.69, based on 1,006 companies in the industry. Companies in the top quartile (top 25%) have a ROA % significantly above this median, while those in the bottom quartile fall well below. However, ROA % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high ROA % mean?
A high ROA % can signal that a stock is expensive relative to its fundamentals. Return on assets is the ratio of current-period net income to average two-period total assets. View historical data on Shuttle Pharmaceuticals Holdings and its competitors. For the Drug Manufacturers industry, the median ROA % is 2.69 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Shuttle Pharmaceuticals Holdings's current ROA % is -77.25%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Shuttle Pharmaceuticals Holdings stock overvalued right now?
Shuttle Pharmaceuticals Holdings (SHPH) has a current ROA % of -77.25%. The current ROA % is -77.25%. Shuttle Pharmaceuticals Holdings' overall GF Score™ is 24/100 with 1 warning sign to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is ROA % calculated?
ROA % is calculated from a company's financial statements. For Shuttle Pharmaceuticals Holdings (SHPH), the current ROA % is -77.25% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Shuttle Pharmaceuticals Holdings Business Description

Address 401 Professional Drive, Suite 260, Gaithersburg, MD, USA, 20879
Shuttle Pharmaceuticals Holdings Inc is a clinical-stage pharmaceutical company leveraging its proprietary technology to develop novel therapies designed to cure cancers. The company has one operating segment with a focus on the development of novel drug therapies, including cancer therapies, extending new applications of radiation therapy, and other drug development, including through the use of the Molecule.ai platform by the company as well as licensing the right to use Molecuile.ai to others. The company's goal is to extend the benefits of cancer treatments with surgery, radiation therapy, chemotherapy and immunotherapy. Radiation therapy (RT) is one of the effective modalities for treating cancers. Its pipeline includes: Ropidoxuridine, HDAC Inhibitors, PSMA-B, and PC-Rad Test.
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