Advagene Biopharma Co (ROCO:6709) ROE %: -41.45% (As of Dec. 2025)

Author: Vera Yuan Vera Yuan
Vera Yuan
Vera Yuan
Director of Data and Quant Analytics at GuruFocus
Focused on building reliable datasets, financial models, and research tools for value-minded investors. Committed to turning complex data into practical guidance for value-investing and long-term wealth.
Reviewed by: Charlie Tian Charlie Tian
Charlie Tian
Charlie Tian
Founder & CEO of GuruFocus
Dr. Charlie Tian is the founder and CEO of GuruFocus.com, a leading global investment research platform established in 2004. With a Ph.D. in physics, Dr. Tian transitioned from science to finance, applying a data-driven, disciplined approach to value investing.

ROCO:6709 Advagene Biopharma Co Ltd ROCO:6709
36 GF Score
Price NT$24.55
! 2 Warning Signs
View Full Analysis

What is Advagene Biopharma Co ROE %?

Advagene Biopharma Co ROCO:6709 +0.41% 36 ROE % is -41.45% as of Dec. 2025. GuruFocus rates ROCO:6709 with a GF Score™ of 36/100. The stock has 2 warning signs investors should review. Among 1,249 Biotechnology companies, Advagene Biopharma Co ranks better than 51.08% on this metric.

ROE % is calculated as Net Income divided by its average Total Stockholders Equity over a certain period of time. Advagene Biopharma Co's annualized net income for the quarter that ended in Dec. 2025 was NT$-70.41 Mil. Advagene Biopharma Co's average Total Stockholders Equity over the quarter that ended in Dec. 2025 was NT$169.85 Mil. Therefore, Advagene Biopharma Co's annualized ROE % for the quarter that ended in Dec. 2025 was -41.45%.

The historical rank and industry rank for Advagene Biopharma Co's ROE % or its related term are showing as below:

ROCO:6709' s ROE % Range Over the Past 10 Years
Min: -77.89   Med: -39.11   Max: -24.59
Current: -36.57

During the past 10 years, Advagene Biopharma Co's highest ROE % was -24.59%. The lowest was -77.89%. And the median was -39.11%.

ROCO:6709's ROE % is ranked better than
51.08% of 1249 companies
in the Biotechnology industry
Industry Median: -38.45 vs ROCO:6709: -36.57

Advagene Biopharma Co  (ROCO:6709) ROE % Explanation

ROE % measures the rate of return on the ownership interest (shareholder's equity) of the common stock owners. It measures a firm's efficiency at generating profits from every unit of shareholders' equity (also known as net assets or assets minus liabilities). ROE % shows how well a company uses investment funds to generate earnings growth. ROE %s between 15% and 20% are considered desirable.

The factors that affect a company's ROE % can be illustrated with the three-step DuPont Analysis:

ROE %(Q: Dec. 2025 )
=Net Income/Total Stockholders Equity
=-70.406/169.8535
=(Net Income / Revenue )*(Revenue / Total Assets)*(Total Assets / Total Stockholders Equity)
=(-70.406 / 0)*(0 / 181.8845)*(181.8845 / 169.8535)
=Net Margin %*Asset Turnover*Equity Multiplier
=N/A %*0*1.0708
=ROA %*Equity Multiplier
=N/A %*1.0708
=-41.45 %

With this breakdown, it is clear that if a company grows its Net Profit Margin, its Asset Turnover, or its Leverage, it can grow its ROE %.

The factors that affect a company's ROE % can also be illustrated with the five-step DuPont Analysis:

ROE %(Q: Dec. 2025 )
=Net Income/Total Stockholders Equity
=-70.406/169.8535
=(Net Income / Pre-Tax Income) * (Pre-Tax Income / Operating Income) * (Operating Income / Revenue) * (Revenue / Total Assets) * (Total Assets / Total Stockholders Equity)
= (-70.406 / -70.406) * (-70.406 / -72.752) * (-72.752 / 0) * (0 / 181.8845) * (181.8845 / 169.8535)
= Tax Burden * Interest Burden * Operating Margin % * Asset Turnover * Equity Multiplier
= 1 * 0.9678 * N/A % * 0 * 1.0708
=-41.45 %

Note: The net income data used here is two times the semi-annual (Dec. 2025) net income data. The Revenue data used here is two times the semi-annual (Dec. 2025) revenue data. The same rule applies to Pre-Tax Income and Operating Income.
* In the five-step DuPont Analysis, Operating Income is only available for non-financial companies. Thus, for Insurance companies, we use EBIT as a substitution of Operating Income. For Banks, both Operating Income and EBIT is unavailable. Thus we combined Interest Burden and Operating Margin % into Pretax Margin %, and the DuPont Analysis is divided into four components instead.

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.


Be Aware

Net Income is used.

Because a company can increase its ROE % by having more financial leverage, it is important to watch the equity multiplier when investing in high ROE % companies. Like ROA %, ROE % is calculated with only 12 months data. Fluctuations in company's earnings or business cycles can affect the ratio drastically. It is important to look at the ratio from a long term perspective.

Asset light businesses require very few assets to generate very high earnings. Their ROE %s can be extremely high.


Advagene Biopharma Co ROE % Related Terms


Advagene Biopharma Co ROE % Historical Data

* Premium members only.

The historical data trend for Advagene Biopharma Co's ROE % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Advagene Biopharma Co ROE % Chart

Advagene Biopharma Co Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
ROE %
Get a 7-Day Free Trial Premium Member Only Premium Member Only -33.77 -62.09 -67.80 -38.51 -36.64

Advagene Biopharma Co Semi-Annual Data
Dec16 Jun17 Dec17 Jun18 Dec18 Jun19 Dec19 Jun20 Dec20 Jun21 Dec21 Jun22 Dec22 Jun23 Dec23 Jun24 Dec24 Jun25 Dec25
ROE % Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -80.82 -50.55 -46.20 -32.44 -41.45

ROCO:6709 vs VRTX, REGN, ALNY: ROE % Comparison

For the Biotechnology subindustry, Advagene Biopharma Co's ROE %, along with its competitors' market caps and ROE % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Advagene Biopharma Co ROE % vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Advagene Biopharma Co's ROE % distribution charts can be found below:

* The bar in red indicates where Advagene Biopharma Co's ROE % falls into.


ROCO:6709
36GF Score
Advagene Biopharma Co Ltd ROCO:6709
ROE % is just one metric. See GF Score™, valuation, warning signs, and more.
View Full Analysis

Advagene Biopharma Co ROE % Calculation

Advagene Biopharma Co's annualized ROE % for the fiscal year that ended in Dec. 2025 is calculated as

ROE %=Net Income (A: Dec. 2025 )/( (Total Stockholders Equity (A: Dec. 2024 )+Total Stockholders Equity (A: Dec. 2025 ))/ count )
=-68.289/( (220.541+152.252)/ 2 )
=-68.289/186.3965
=-36.64 %

Advagene Biopharma Co's annualized ROE % for the quarter that ended in Dec. 2025 is calculated as

ROE %=Net Income (Q: Dec. 2025 )/( (Total Stockholders Equity (Q: Jun. 2025 )+Total Stockholders Equity (Q: Dec. 2025 ))/ count )
=-70.406/( (187.455+152.252)/ 2 )
=-70.406/169.8535
=-41.45 %

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

In the calculation of annual ROE %, the net income of the last fiscal year and the average total shareholder equity over the fiscal year are used. In calculating the quarterly data, the net income data used here is two times the semi-annual (Dec. 2025) net income data. ROE % is displayed in the 30-year financial page.

Frequently Asked Questions Learn more about ROE % →
What does a ROE % of -41.45% mean?
Advagene Biopharma Co (ROCO:6709) has a ROE % of -41.45% as of Dec. 2025. Return on equity is the ratio of current-period net income to average two-period total equity. View historical data on Advagene Biopharma Co and its competitors. According to the industry distribution chart, Advagene Biopharma Co ranks #611 out of 1249 companies in the Biotechnology industry, placing it in the top 48.9%.
Is Advagene Biopharma Co's ROE % too high?
Advagene Biopharma Co's current ROE % is -41.45%. Based on the distribution chart, Advagene Biopharma Co ranks #611 out of 1249 companies in the Biotechnology industry, which is above the industry midpoint. Overall, Advagene Biopharma Co has a GF Score™ of 36/100, reflecting its overall financial health beyond just this single metric.
How does Advagene Biopharma Co's ROE % compare to VRTX and REGN?
According to the Biotechnology industry distribution chart, Advagene Biopharma Co ranks #611 out of 1249 companies for ROE %. This puts Advagene Biopharma Co in the upper half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good ROE % for a Biotechnology company?
A good ROE % depends on the Biotechnology industry context. However, ROE % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high ROE % mean?
A high ROE % can signal that a stock is expensive relative to its fundamentals. Return on equity is the ratio of current-period net income to average two-period total equity. View historical data on Advagene Biopharma Co and its competitors. Advagene Biopharma Co's current ROE % is -41.45%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Advagene Biopharma Co stock overvalued right now?
Advagene Biopharma Co (ROCO:6709) has a current ROE % of -41.45%. The current ROE % is -41.45%. Advagene Biopharma Co's overall GF Score™ is 36/100 with 2 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is ROE % calculated?
ROE % is calculated from a company's financial statements. For Advagene Biopharma Co (ROCO:6709), the current ROE % is -41.45% as of Dec. 2025. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Advagene Biopharma Co Business Description

Address Sector 1, Neihu Road, 6 Floor, No.308, Neihu District, Taipei, TWN, 114
Advagene Biopharma Co Ltd is a Taiwan based immune-modulatory platform-based biotechnology company. The company has completed technology transfer with DCB for detoxified LT Adjuvant Technology Platform. Its product development includes nasal spray seasonal flu vaccine, nasal spray COVID-19 vaccine, Immunotherapy for COVID-19, Respiratory Allergy Immunotherapy - Allergic Rhinitis and Asthma ,and other vaccines.
36GF Score

Get the complete analysis for ROCO:6709

ROE % is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

NT$24.55
Price