ANAB (AnaptysBio) ROIC %: -570.77% (As of Mar. 2026)


ANAB AnaptysBio Inc ANAB
67 GF Score
Price $60.80
GF Value $61.78
Valuation Fairly Valued
! 3 Warning Signs
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What is AnaptysBio ROIC %?

AnaptysBio ANAB +1.89% 67 ROIC % is -570.77% as of Mar. 2026. GuruFocus rates ANAB with a GF Score™ of 67/100 and a GF Value™ of $61.78 (Fairly Valued). The stock has 3 warning signs investors should review.

ROIC % measures how well a company generates cash flow relative to the capital it has invested in its business. It is also called ROC %. AnaptysBio's annualized return on invested capital (ROIC %) for the quarter that ended in Mar. 2026 was -570.77%.

As of today (2026-06-26), AnaptysBio's WACC % is 18.09%. AnaptysBio's ROIC % is 82.57% (calculated using TTM income statement data). AnaptysBio generates higher returns on investment than it costs the company to raise the capital needed for that investment. It is earning excess returns. A firm that expects to continue generating positive excess returns on new investments in the future will see its value increase as growth increases.


AnaptysBio  (NAS:ANAB) ROIC % Explanation

ROIC % measures how well a company generates cash flow relative to the capital it has invested in its business. It is also called ROC %. The reason book values of debt and equity are used is because the book values are the capital the company received when issuing the debt or receiving the equity investments.

There are four key components to this definition. The first is the use of operating income or EBIT rather than net income in the numerator. The second is the tax adjustment to this operating income or EBIT, computed as a hypothetical tax based on an effective or marginal tax rate. The third is the use of book values for invested capital, rather than market values. The final is the timing difference; the capital invested is from the end of the prior year whereas the operating income or EBIT is the current year's number.

Why is ROIC % important?

Because it costs money to raise capital. A firm that generates higher returns on investment than it costs the company to raise the capital needed for that investment is earning excess returns. A firm that expects to continue generating positive excess returns on new investments in the future will see its value increase as growth increases, whereas a firm that earns returns that do not match up to its cost of capital will destroy value as it grows.

As of today, AnaptysBio's WACC % is 18.09%. AnaptysBio's ROIC % is 82.57% (calculated using TTM income statement data). AnaptysBio generates higher returns on investment than it costs the company to raise the capital needed for that investment. It is earning excess returns. A firm that expects to continue generating positive excess returns on new investments in the future will see its value increase as growth increases.


Be Aware

Like ROE % and ROA %, ROIC % is calculated with only 12 months of data. Fluctuations in the company's earnings or business cycles can affect the ratio drastically. It is important to look at the ratio from a long term perspective.


AnaptysBio ROIC % Related Terms


AnaptysBio ROIC % Historical Data

* Premium members only.

The historical data trend for AnaptysBio's ROIC % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

AnaptysBio ROIC % Chart

AnaptysBio Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
ROIC %
Get a 7-Day Free Trial Premium Member Only Premium Member Only -95.57 -86.89 -139.79 -194.93 105.58

AnaptysBio Quarterly Data
Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
ROIC % Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -165.56 -172.44 215.50 511.81 -570.77

ANAB vs VIR, GHRS, INVA: ROIC % Comparison

For the Biotechnology subindustry, AnaptysBio's ROIC %, along with its competitors' market caps and ROIC % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


AnaptysBio ROIC % vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, AnaptysBio's ROIC % distribution charts can be found below:

* The bar in red indicates where AnaptysBio's ROIC % falls into.


ANAB
67GF Score
AnaptysBio Inc ANAB
ROIC % is just one metric. See GF Score™, valuation, warning signs, and more.
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AnaptysBio ROIC % Calculation

AnaptysBio's annualized Return on Invested Capital (ROIC %) for the fiscal year that ended in Dec. 2025 is calculated as:

ROIC % (A: Dec. 2025 )
=NOPAT/Average Invested Capital
=Operating Income * ( 1 - Tax Rate % )/( (Invested Capital (A: Dec. 2024 ) + Invested Capital (A: Dec. 2025 ))/ count )
=47.896 * ( 1 - 0% )/( (63.407 + 27.319)/ 2 )
=47.896/45.363
=105.58 %

where

Invested Capital(A: Dec. 2024 )
=Total Assets - Accounts Payable & Accrued Expense - Excess Cash
=Total Assets - Accounts Payable & Accrued Expense - ( Cash, Cash Equivalents, Marketable Securities - max(0, Total Current Liabilities - Total Current Assets+Cash, Cash Equivalents, Marketable Securities))
=483.834 - 35.054 - ( 385.373 - max(0, 45.428 - 431.876+385.373))
=63.407

AnaptysBio's annualized Return on Invested Capital (ROIC %) for the quarter that ended in Mar. 2026 is calculated as:

ROIC % (Q: Mar. 2026 )
=NOPAT/Average Invested Capital
=Operating Income * ( 1 - Tax Rate % )/( (Invested Capital (Q: Dec. 2025 ) + Invested Capital (Q: Mar. 2026 ))/ count )
=-138.548 * ( 1 - 0% )/( (27.319 + 21.229)/ 2 )
=-138.548/24.274
=-570.77 %

where

Invested Capital(Q: Mar. 2026 )
=Total Assets - Accounts Payable & Accrued Expense - Excess Cash
=Total Assets - Accounts Payable & Accrued Expense - ( Cash, Cash Equivalents, Marketable Securities - max(0, Total Current Liabilities - Total Current Assets+Cash, Cash Equivalents, Marketable Securities))
=329.684 - 34.048 - ( 286.455 - max(0, 41.702 - 316.109+286.455))
=21.229

Note: The Operating Income data used here is four times the quarterly (Mar. 2026) data. The tax rate is limited to between 0% and 100%.

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Frequently Asked Questions Learn more about ROIC % →
What does a ROIC % of -570.77% mean?
AnaptysBio (ANAB) has a ROIC % of -570.77% as of Mar. 2026. Return on invested capital is the ratio of current-period net income to average two-period invested capital. View historical data on AnaptysBio and its competitors.
Is AnaptysBio's ROIC % too high?
AnaptysBio's current ROIC % is -570.77%. Overall, AnaptysBio has a GF Score™ of 67/100 and is considered Fairly Valued, reflecting its overall financial health beyond just this single metric.
How does AnaptysBio's ROIC % compare to VIR and GHRS?
AnaptysBio's ROIC % of -570.77% can be compared against companies in the Biotechnology industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good ROIC % for a Biotechnology company?
A good ROIC % depends on the Biotechnology industry context. However, ROIC % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high ROIC % mean?
A high ROIC % can signal that a stock is expensive relative to its fundamentals. Return on invested capital is the ratio of current-period net income to average two-period invested capital. View historical data on AnaptysBio and its competitors. AnaptysBio's current ROIC % is -570.77%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is AnaptysBio stock overvalued right now?
Based on GuruFocus' analysis, AnaptysBio (ANAB) is currently considered Fairly Valued. The stock's GF Value™ is $61.78, compared to a current price of $60.80 — trading 1.6% below its estimated fair value. The current ROIC % is -570.77%. AnaptysBio's overall GF Score™ is 67/100 with 3 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is ROIC % calculated?
ROIC % is calculated from a company's financial statements. For AnaptysBio (ANAB), the current ROIC % is -570.77% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is AnaptysBio (ANAB) Overvalued in 2026?

Based on GuruFocus' analysis, AnaptysBio stock appears to be undervalued. The current stock price of $60.80 is trading 1.6% below its estimated GF Value™ of $61.78. GuruFocus considers AnaptysBio to be Fairly Valued.

Key valuation signals for ANAB:

  • ROIC %: -570.77%
  • GF Value™: $61.78 vs. price of $60.80 (1.6% below fair value)
  • GF Score™: 67/100 with 3 warning signs

No single metric tells the full story. See the ANAB stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


AnaptysBio Business Description

Other Exchanges 0HFQ:UKAN6:Germany
Address 10770 Wateridge Circle, Suite 210, San Diego, CA, USA, 92121
AnaptysBio Inc is a clinical-stage biotechnology company. The company is focused on developing antibody product candidates for unmet medical needs in inflammation and immuno-oncology. The company is developing immune cell modulating antibodies, including two wholly owned checkpoint agonists in clinical-stage development, for autoimmune and inflammatory diseases; rosnilimab, PD-1 agonist in a Phase 2b trial for the treatment of moderate-to-severe rheumatoid arthritis (RA) and a Phase 2 trial for the treatment of moderate-to-severe ulcerative colitis (UC); and ANB032, BTLA agonist, in a Phase 2b trial for the treatment of moderate-to-severe atopic dermatitis (AD).
67GF Score

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ROIC % is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

$60.80
Price
$61.78
GF Value