LIPO (Lipella Pharmaceuticals) ROIC %: -1,590.02% (As of Sep. 2025)


What is Lipella Pharmaceuticals ROIC %?

Lipella Pharmaceuticals LIPO +8.43% ROIC % is -1,590.02% as of Sep. 2025. The stock has 1 warning sign investors should review.

ROIC % measures how well a company generates cash flow relative to the capital it has invested in its business. It is also called ROC %. Lipella Pharmaceuticals's annualized return on invested capital (ROIC %) for the quarter that ended in Sep. 2025 was -1,590.02%.

As of today (2026-06-26), Lipella Pharmaceuticals's WACC % is 10.29%. Lipella Pharmaceuticals's ROIC % is -2765.85% (calculated using TTM income statement data). Lipella Pharmaceuticals earns returns that do not match up to its cost of capital. It will destroy value as it grows.


Lipella Pharmaceuticals  (OTCPK:LIPO) ROIC % Explanation

ROIC % measures how well a company generates cash flow relative to the capital it has invested in its business. It is also called ROC %. The reason book values of debt and equity are used is because the book values are the capital the company received when issuing the debt or receiving the equity investments.

There are four key components to this definition. The first is the use of operating income or EBIT rather than net income in the numerator. The second is the tax adjustment to this operating income or EBIT, computed as a hypothetical tax based on an effective or marginal tax rate. The third is the use of book values for invested capital, rather than market values. The final is the timing difference; the capital invested is from the end of the prior year whereas the operating income or EBIT is the current year's number.

Why is ROIC % important?

Because it costs money to raise capital. A firm that generates higher returns on investment than it costs the company to raise the capital needed for that investment is earning excess returns. A firm that expects to continue generating positive excess returns on new investments in the future will see its value increase as growth increases, whereas a firm that earns returns that do not match up to its cost of capital will destroy value as it grows.

As of today, Lipella Pharmaceuticals's WACC % is 10.29%. Lipella Pharmaceuticals's ROIC % is -2765.85% (calculated using TTM income statement data). Lipella Pharmaceuticals earns returns that do not match up to its cost of capital. It will destroy value as it grows.


Be Aware

Like ROE % and ROA %, ROIC % is calculated with only 12 months of data. Fluctuations in the company's earnings or business cycles can affect the ratio drastically. It is important to look at the ratio from a long term perspective.


Lipella Pharmaceuticals ROIC % Related Terms


Lipella Pharmaceuticals ROIC % Historical Data

* Premium members only.

The historical data trend for Lipella Pharmaceuticals's ROIC % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Lipella Pharmaceuticals ROIC % Chart

Lipella Pharmaceuticals Annual Data
Trend Dec20 Dec21 Dec22 Dec23 Dec24
ROIC %
-14.73 -583.26 -687.00 -1,316.50 -2,980.06

Lipella Pharmaceuticals Quarterly Data
Dec20 Mar21 Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25
ROIC % Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -1,484.99 -4,145.71 -6,598.76 -2,834.46 -1,590.02

LIPO vs WINT, RMTG, CYTOF: ROIC % Comparison

For the Biotechnology subindustry, Lipella Pharmaceuticals's ROIC %, along with its competitors' market caps and ROIC % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Lipella Pharmaceuticals ROIC % vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Lipella Pharmaceuticals's ROIC % distribution charts can be found below:

* The bar in red indicates where Lipella Pharmaceuticals's ROIC % falls into.



Lipella Pharmaceuticals ROIC % Calculation

Lipella Pharmaceuticals's annualized Return on Invested Capital (ROIC %) for the fiscal year that ended in Dec. 2024 is calculated as:

ROIC % (A: Dec. 2024 )
=NOPAT/Average Invested Capital
=Operating Income * ( 1 - Tax Rate % )/( (Invested Capital (A: Dec. 2023 ) + Invested Capital (A: Dec. 2024 ))/ count )
=-5.081 * ( 1 - 0% )/( (0.237 + 0.104)/ 2 )
=-5.081/0.1705
=-2,980.06 %

where

Lipella Pharmaceuticals's annualized Return on Invested Capital (ROIC %) for the quarter that ended in Sep. 2025 is calculated as:

ROIC % (Q: Sep. 2025 )
=NOPAT/Average Invested Capital
=Operating Income * ( 1 - Tax Rate % )/( (Invested Capital (Q: Jun. 2025 ) + Invested Capital (Q: Sep. 2025 ))/ count )
=-5.096 * ( 1 - 0% )/( (0.326 + 0.315)/ 2 )
=-5.096/0.3205
=-1,590.02 %

where

Note: The Operating Income data used here is four times the quarterly (Sep. 2025) data. The tax rate is limited to between 0% and 100%.

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Frequently Asked Questions Learn more about ROIC % →
What does a ROIC % of -1,590.02% mean?
Lipella Pharmaceuticals (LIPO) has a ROIC % of -1,590.02% as of Sep. 2025. Return on invested capital is the ratio of current-period net income to average two-period invested capital. View historical data on Lipella Pharmaceuticals and its competitors.
Is Lipella Pharmaceuticals' ROIC % too high?
Lipella Pharmaceuticals' current ROIC % is -1,590.02%.
How does Lipella Pharmaceuticals' ROIC % compare to WINT and RMTG?
Lipella Pharmaceuticals' ROIC % of -1,590.02% can be compared against companies in the Biotechnology industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good ROIC % for a Biotechnology company?
A good ROIC % depends on the Biotechnology industry context. However, ROIC % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high ROIC % mean?
A high ROIC % can signal that a stock is expensive relative to its fundamentals. Return on invested capital is the ratio of current-period net income to average two-period invested capital. View historical data on Lipella Pharmaceuticals and its competitors. Lipella Pharmaceuticals's current ROIC % is -1,590.02%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Lipella Pharmaceuticals stock overvalued right now?
Based on GuruFocus' analysis, Lipella Pharmaceuticals (LIPO) is currently considered Possible Value Trap. The stock's GF Value™ is $8.67, compared to a current price of $0.09 — trading 99% below its estimated fair value. The current ROIC % is -1,590.02%. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is ROIC % calculated?
ROIC % is calculated from a company's financial statements. For Lipella Pharmaceuticals (LIPO), the current ROIC % is -1,590.02% as of Sep. 2025. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Lipella Pharmaceuticals Business Description

Address 7800 Susquehanna Street, Suite 505, Pittsburgh, PA, USA, 15208
Lipella Pharmaceuticals Inc is a clinical-stage biotechnology company. The company is focused on developing new drugs by reformulating the active agents in existing generic drugs and optimizing these reformulations for new applications. The company's product candidates include LP-10, LP-310 and LP-410, which can be helpful in the treatment of Hemorrahagic Cystitis, Oral Licen Planus and Oral Graft.