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3-Year Return on Invested Incremental Capital (3-Year ROIIC %) measures the change in earnings as a percentage of change in investment over 3-year.
Senti Biosciences Holdings's 3-Year ROIIC % for the quarter that ended in Dec. 2025 was 3.43%. High ROIIC is generally an indication that your business is capital efficient or has a higher operating leverage.
The industry rank for Senti Biosciences Holdings's 3-Year ROIIC % or its related term are showing as below:
SNTI's 3-Year ROIIC % is ranked better than 56.2% of 1322
companies
in the Biotechnology industry
Industry Median: -4.835
vs SNTI: 3.43
Return on Incremental Invested Capital (ROIIC) is an extension of Return on Investment Capital (ROIC). ROIC % tells investors how efficiently that profitability is earned per dollar of company capital. ROIIC narrows the focus even further and shows how profitable each additional unit of capital investment could be. ROIIC % is a more powerful metric than ROIC because it measures how much money the company can generate going forward on future capital investments.
High ROIIC is generally an indication that your business is capital efficient or has a higher operating leverage.
Be Aware
It's important to keep in mind that when tracking ROIIC, the metric is better suited to forecasting the trend of future returns rather than measuring current return on investment.
Senti Biosciences Holdings 3-Year ROIIC % Related Terms
Senti Biosciences Holdings 3-Year ROIIC % Historical Data
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
SNTI vs ALGS, CRVO, NTRB: 3-Year ROIIC % Comparison
For the Biotechnology subindustry, Senti Biosciences Holdings's 3-Year ROIIC %, along with its competitors' market caps and 3-Year ROIIC % data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Senti Biosciences Holdings 3-Year ROIIC % vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Senti Biosciences Holdings's 3-Year ROIIC % distribution charts can be found below:
* The bar in red indicates where Senti Biosciences Holdings's 3-Year ROIIC % falls into.
3-Year Incremental Net Operating Profit After Taxes (NOPAT)**
/
3-Year Incremental Invested Capital**
=
( -63.727 (Dec. 2025) - -62.084 (Dec. 2022) )
/
( 36.064 (Dec. 2025) - 84.029 (Dec. 2022) )
=
-1.643
/
-47.965
=
3.43%***
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
** Annual data of NOPAT and Invested Capital was used to calculate 3-Year ROIIC %.
*** Please be aware that the ROIIC (Return on Invested Capital) calculations are based on company-level data using the primary share class. The calculated data provided is for demonstration purposes and may slightly differ from the results displayed in the title due to potential variations caused by currency exchange rate differences throughout the year.
Senti Biosciences Holdings (SNTI) has a 3-Year ROIIC % of 3.43 as of Dec. 2025. 3-Year ROIIC % measures the change in earnings as a percentage of change in investment over 3-year. View historical data on Senti Biosciences Holdings and its competitors. According to the industry distribution chart, Senti Biosciences Holdings ranks #579 out of 1322 companies in the Biotechnology industry, placing it in the top 43.8%.
Is Senti Biosciences Holdings' 3-Year ROIIC % too high?
Senti Biosciences Holdings' current 3-Year ROIIC % is 3.43. Based on the distribution chart, Senti Biosciences Holdings ranks #579 out of 1322 companies in the Biotechnology industry, which is above the industry midpoint. Overall, Senti Biosciences Holdings has a GF Score™ of 23/100, reflecting its overall financial health beyond just this single metric.
How does Senti Biosciences Holdings' 3-Year ROIIC % compare to ALGS and CRVO?
According to the Biotechnology industry distribution chart, Senti Biosciences Holdings ranks #579 out of 1322 companies for 3-Year ROIIC %. This puts Senti Biosciences Holdings in the upper half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good 3-Year ROIIC % for a Biotechnology company?
A good 3-Year ROIIC % depends on the Biotechnology industry context. However, 3-Year ROIIC % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high 3-Year ROIIC % mean?
A high 3-Year ROIIC % can signal that a stock is expensive relative to its fundamentals. 3-Year ROIIC % measures the change in earnings as a percentage of change in investment over 3-year. View historical data on Senti Biosciences Holdings and its competitors. Senti Biosciences Holdings's current 3-Year ROIIC % is 3.43. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Senti Biosciences Holdings stock overvalued right now?
Senti Biosciences Holdings (SNTI) has a current 3-Year ROIIC % of 3.43. The current 3-Year ROIIC % is 3.43. Senti Biosciences Holdings' overall GF Score™ is 23/100 with 6 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is 3-Year ROIIC % calculated?
3-Year ROIIC % is calculated from a company's financial statements. For Senti Biosciences Holdings (SNTI), the current 3-Year ROIIC % is 3.43 as of Dec. 2025. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Senti Biosciences Holdings Inc, formerly known as Senti Biosciences Inc, is a clinical-stage biotechnology company developing cell and gene therapies using its gene circuit platform for patients with incurable diseases. Its gene circuits, created from proprietary DNA sequences, are designed to reprogram cells to sense, compute, and respond to cellular environments. Its product candidates are to kill cancer cells, spare healthy cells, increase specificity, and control drug expression. Its candidate, SENTI-202, is a logic-gated off-the-shelf CAR-NK cell therapy for blood cancers, currently in a Phase 1 clinical trial in the United States and Australia for relapsed or refractory hematological malignancies, including Acute Myeloid Leukemia (AML).
23GF Score
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