SNTI (Senti Biosciences Holdings) 1-Year Sharpe Ratio: -0.78 (As of Aug. 24, 2026)

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SNTI Senti Biosciences Holdings Inc SNTI
18 GF Score
Price $0.38
! 6 Warning Signs
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What is Senti Biosciences Holdings 1-Year Sharpe Ratio?

Senti Biosciences Holdings SNTI -0.53% 18 1-Year Sharpe Ratio is -0.78 as of Aug. 24, 2026. GuruFocus rates SNTI with a GF Score™ of 18/100. The stock has 6 warning signs investors should review.

The 1-Year Sharpe Ratio measures the additional return that an investor receives per unit of increase in risk over the past year. As of today (2026-08-24), Senti Biosciences Holdings's 1-Year Sharpe Ratio is -0.78.

Senti Biosciences Holdings  (NAS:SNTI) 1-Year Sharpe Ratio Explanation

The 1-Year Sharpe Ratio inidicates the risk-adjusted return of an investment over the past year. It is calculated as the annualized result of the average monthly excess return divided by its standard deviation over the past year. The monthly excess return is the monthly investment return minus the monthly risk-free rate (typically the 10-year Treasury Constant Maturity Rate). If the risk-free rate for a specific region is not available, U.S. data is used by default.

The greater a portfolio's Sharpe Ratio, the better its risk-adjusted performance. A negative Sharpe Ratio means the risk-free rate is greater than the portfolio’s historical or projected return, or else the portfolio's return is expected to be negative.

Senti Biosciences Holdings 1-Year Sharpe Ratio Related Terms

SNTI vs ZEOX, BCDA, COCP: 1-Year Sharpe Ratio Comparison

For the Biotechnology subindustry, Senti Biosciences Holdings's 1-Year Sharpe Ratio, along with its competitors' market caps and 1-Year Sharpe Ratio data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.

Senti Biosciences Holdings 1-Year Sharpe Ratio vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Senti Biosciences Holdings's 1-Year Sharpe Ratio distribution charts can be found below:

* The bar in red indicates where Senti Biosciences Holdings's 1-Year Sharpe Ratio falls into.


SNTI
18GF Score
Senti Biosciences Holdings Inc SNTI
1-Year Sharpe Ratio is just one metric. See GF Score™, valuation, warning signs, and more.
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Senti Biosciences Holdings 1-Year Sharpe Ratio Calculation

The 1-Year Sharpe Ratio measures the performance of an investment such as a stock or portfolio compared to a risk-free asset. A stock / portfolio's 1-Year Sharpe Ratio can be calculated by dividing the difference between the one-year returns of the investment and the risk-free rate, by the standard deviation of the investment returns over one year.

Frequently Asked Questions Learn more about 1-Year Sharpe Ratio →
What does a 1-Year Sharpe Ratio of -0.78 mean?
Senti Biosciences Holdings (SNTI) has a 1-Year Sharpe Ratio of -0.78 as of Aug. 24, 2026. 1-Year Sharpe Ratio measures the additional return that an investor receives per unit of increase in risk. View historical data for Senti Biosciences Holdings and its competitors.
Is Senti Biosciences Holdings' 1-Year Sharpe Ratio too high?
Senti Biosciences Holdings' current 1-Year Sharpe Ratio is -0.78. Overall, Senti Biosciences Holdings has a GF Score™ of 18/100, reflecting its overall financial health beyond just this single metric.
How does Senti Biosciences Holdings' 1-Year Sharpe Ratio compare to ZEOX and BCDA?
Senti Biosciences Holdings' 1-Year Sharpe Ratio of -0.78 can be compared against companies in the Biotechnology industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good 1-Year Sharpe Ratio for a Biotechnology company?
A good 1-Year Sharpe Ratio depends on the Biotechnology industry context. However, 1-Year Sharpe Ratio should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high 1-Year Sharpe Ratio mean?
A high 1-Year Sharpe Ratio can signal that a stock is expensive relative to its fundamentals. 1-Year Sharpe Ratio measures the additional return that an investor receives per unit of increase in risk. View historical data for Senti Biosciences Holdings and its competitors. Senti Biosciences Holdings's current 1-Year Sharpe Ratio is -0.78. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Senti Biosciences Holdings stock overvalued right now?
Senti Biosciences Holdings (SNTI) has a current 1-Year Sharpe Ratio of -0.78. The current 1-Year Sharpe Ratio is -0.78. Senti Biosciences Holdings' overall GF Score™ is 18/100 with 6 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is 1-Year Sharpe Ratio calculated?
1-Year Sharpe Ratio is calculated from a company's financial statements. For Senti Biosciences Holdings (SNTI), the current 1-Year Sharpe Ratio is -0.78 as of Aug. 24, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Senti Biosciences Holdings Business Description

Address 2 Corporate Drive, First Floor, South San Francisco, CA, USA, 94080
Senti Biosciences Holdings Inc, formerly known as Senti Biosciences Inc, is a clinical-stage biotechnology company developing cell and gene therapies using its gene circuit platform for patients with incurable diseases. Its gene circuits, created from proprietary DNA sequences, are designed to reprogram cells to sense, compute, and respond to cellular environments. Its product candidates are to kill cancer cells, spare healthy cells, increase specificity, and control drug expression. Its candidate, SENTI-202, is a logic-gated off-the-shelf CAR-NK cell therapy for blood cancers, currently in a Phase 1 clinical trial in the United States and Australia for relapsed or refractory hematological malignancies, including Acute Myeloid Leukemia (AML).
18GF Score

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1-Year Sharpe Ratio is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

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