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Instil BioTIL -1.25%31 5-Year ROIIC % is -39.04 as of Dec. 2025. GuruFocus rates TIL with a GF Score™ of 31/100. The stock has 3 warning signs investors should review. Among 1,172 Biotechnology companies, Instil Bio ranks worse than 60.67% on this metric.
5-Year Return on Invested Incremental Capital (5-Year ROIIC %) measures the change in earnings as a percentage of change in investment over 5-year.
Instil Bio's 5-Year ROIIC % for the quarter that ended in Dec. 2025 was -39.04%. High ROIIC is generally an indication that your business is capital efficient or has a higher operating leverage.
The industry rank for Instil Bio's 5-Year ROIIC % or its related term are showing as below:
TIL's 5-Year ROIIC % is ranked worse than 60.67% of 1172
companies
in the Biotechnology industry
Industry Median: -11.085
vs TIL: -39.04
Instil Bio (NAS:TIL) 5-Year ROIIC % Explanation
Return on Incremental Invested Capital (ROIIC) is an extension of Return on Investment Capital (ROIC). ROIC % tells investors how efficiently that profitability is earned per dollar of company capital. ROIIC narrows the focus even further and shows how profitable each additional unit of capital investment could be. ROIIC % is a more powerful metric than ROIC because it measures how much money the company can generate going forward on future capital investments.
High ROIIC is generally an indication that your business is capital efficient or has a higher operating leverage.
Be Aware
It's important to keep in mind that when tracking ROIIC, the metric is better suited to forecasting the trend of future returns rather than measuring current return on investment.
Instil Bio 5-Year ROIIC % Related Terms
Instil Bio 5-Year ROIIC % Historical Data
* Premium members only.
The historical data trend for Instil Bio's 5-Year ROIIC % can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
TIL vs AURX, MCRB, DWTX: 5-Year ROIIC % Comparison
For the Biotechnology subindustry, Instil Bio's 5-Year ROIIC %, along with its competitors' market caps and 5-Year ROIIC % data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Instil Bio 5-Year ROIIC % vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Instil Bio's 5-Year ROIIC % distribution charts can be found below:
* The bar in red indicates where Instil Bio's 5-Year ROIIC % falls into.
Instil Bio's 5-Year ROIIC % for the quarter that ended in Dec. 2025 is calculated as:
5-Year ROIIC %
=
5-Year Incremental Net Operating Profit After Taxes (NOPAT)**
/
5-Year Incremental Invested Capital**
=
( -51.959 (Dec. 2025) - -33.644 (Dec. 2020) )
/
( 125.44 (Dec. 2025) - 78.522 (Dec. 2020) )
=
-18.315
/
46.918
=
-39.04%***
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
** Annual data of NOPAT and Invested Capital was used to calculate 5-Year ROIIC %.
*** Please be aware that the ROIIC (Return on Invested Capital) calculations are based on company-level data using the primary share class. The calculated data provided is for demonstration purposes and may slightly differ from the results displayed in the title due to potential variations caused by currency exchange rate differences throughout the year.
Instil Bio (TIL) has a 5-Year ROIIC % of -39.04 as of Dec. 2025. 5-Year ROIIC % measures the change in earnings as a percentage of change in investment over 5-year. View historical data on Instil Bio and its competitors. According to the industry distribution chart, Instil Bio ranks #711 out of 1172 companies in the Biotechnology industry, placing it in the top 60.7%.
Is Instil Bio's 5-Year ROIIC % too high?
Instil Bio's current 5-Year ROIIC % is -39.04. Based on the distribution chart, Instil Bio ranks #711 out of 1172 companies in the Biotechnology industry, which is below the industry midpoint. Overall, Instil Bio has a GF Score™ of 31/100, reflecting its overall financial health beyond just this single metric.
How does Instil Bio's 5-Year ROIIC % compare to AURX and MCRB?
According to the Biotechnology industry distribution chart, Instil Bio ranks #711 out of 1172 companies for 5-Year ROIIC %. This places Instil Bio in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good 5-Year ROIIC % for a Biotechnology company?
A good 5-Year ROIIC % depends on the Biotechnology industry context. However, 5-Year ROIIC % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high 5-Year ROIIC % mean?
A high 5-Year ROIIC % can signal that a stock is expensive relative to its fundamentals. 5-Year ROIIC % measures the change in earnings as a percentage of change in investment over 5-year. View historical data on Instil Bio and its competitors. Instil Bio's current 5-Year ROIIC % is -39.04. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Instil Bio stock overvalued right now?
Instil Bio (TIL) has a current 5-Year ROIIC % of -39.04. The current 5-Year ROIIC % is -39.04. Instil Bio's overall GF Score™ is 31/100 with 3 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is 5-Year ROIIC % calculated?
5-Year ROIIC % is calculated from a company's financial statements. For Instil Bio (TIL), the current 5-Year ROIIC % is -39.04 as of Dec. 2025. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Instil Bio Inc is a clinical-stage biopharmaceutical company focused on developing a cell therapy pipeline of autologous tumor infiltrating lymphocyte, or TIL, therapies for the treatment of patients with cancer. It is also engaged in developing a novel class of genetically engineered TIL therapies using its Co-Stimulatory Antigen Receptor, or CoStAR, platform. Its pipeline includes ITIL-306 which expresses a CoStAR molecule designed to recognize, a tumor-associated antigen that is expressed on numerous solid tumors, including ovarian cancer, uterine cancer, NSCLC, and renal cancer.
31GF Score
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