LYEL (Lyell Immunopharma) 3-Year RORE % : -9.22% (As of Jun. 2026)

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LYEL Lyell Immunopharma Inc LYEL
55 GF Score
Price $14.53
GF Value $3.71
Valuation Significantly Overvalued
! 6 Warning Signs
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What is Lyell Immunopharma 3-Year RORE %?

Lyell Immunopharma LYEL +0.94% 55 3-Year RORE % is -9.22 as of Jun. 2026. GuruFocus rates LYEL with a GF Score™ of 55/100 and a GF Value™ of $3.71 (Significantly Overvalued). The stock has 6 warning signs investors should review. Among 1,296 Biotechnology companies, Lyell Immunopharma ranks better than 51.85% on this metric.

Return on Retained Earnings (RORE) is an indicator of a company's growth potential, it shows how much a company earns by reinvesting its retained earnings, i.e. profits after dividend payments. Lyell Immunopharma's 3-Year RORE % for the quarter that ended in Jun. 2026 was -9.22%.

The industry rank for Lyell Immunopharma's 3-Year RORE % or its related term are showing as below:

LYEL's 3-Year RORE % is ranked better than
51.85% of 1296 companies
in the Biotechnology industry
Industry Median: -11.145 vs LYEL: -9.22

Lyell Immunopharma  (NAS:LYEL) 3-Year RORE % Explanation

Return on Retained Earnings (RORE) is important to investors because it reveals a company's efficiency and growth potential. A higher RORE indicates a higher return. A high RORE indicates that the company should reinvest profits into the business. A lower RORE suggests that the company should distribute profits to shareholders by paying out dividends, since those dollars aren't generating much additional growth for the company.

There are a several different ways to arrive at the Return on Retained Earnings. The simplest way to calculate it is by using published information on Earnings per Share (EPS) and Dividend per Share (DPS) over a selected period. Here, 3-year period is chosen.

Be Aware

Please keep in mind that the RORE is relative to the nature of the business and its competitors. If another company in the same sector is producing a lower return on retained earnings, it doesn’t necessarily mean it’s a bad investment. It may just suggest the company is older and no longer in a high growth stage. At such a stage in the business cycle, it would be expected to see a lower RORE and higher dividend payout.


Lyell Immunopharma 3-Year RORE % Related Terms


Lyell Immunopharma 3-Year RORE % Historical Data

* Premium members only.

The historical data trend for Lyell Immunopharma's 3-Year RORE % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Lyell Immunopharma 3-Year RORE % Chart

Lyell Immunopharma Annual Data
Trend Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
3-Year RORE %
Get a 7-Day Free Trial 0.00 -6.12 -33.36 17.28 -5.99

Lyell Immunopharma Quarterly Data
Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26 Jun26
3-Year RORE % Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only 10.90 12.09 -5.99 -9.84 -9.22

LYEL vs FHTX, ZNTL, PALI: 3-Year RORE % Comparison

For the Biotechnology subindustry, Lyell Immunopharma's 3-Year RORE %, along with its competitors' market caps and 3-Year RORE % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Lyell Immunopharma 3-Year RORE % vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Lyell Immunopharma's 3-Year RORE % distribution charts can be found below:

* The bar in red indicates where Lyell Immunopharma's 3-Year RORE % falls into.


LYEL
55GF Score
Lyell Immunopharma Inc LYEL
3-Year RORE % is just one metric. See GF Score™, valuation, warning signs, and more.
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Lyell Immunopharma 3-Year RORE % Calculation

Lyell Immunopharma's 3-Year RORE % for the quarter that ended in Jun. 2026 is calculated as:

3-Year RORE %=( Most Recent EPS (Diluted)- First Period EPS (Diluted) )/( Cumulative EPS (Diluted) for 3-year -Cumulative Dividends per Share for 3-year )
=( -11.772--16.49 )/( -51.19-0 )
=4.718/-51.19
=-9.22 %

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

In the calculation of 3-Year RORE %, the most recent and first period EPS (Diluted) is the trailing twelve months (TTM) data ended in Jun. 2026 and 3-year before.

Frequently Asked Questions Learn more about 3-Year RORE % →
What does a 3-Year RORE % of -9.22 mean?
Lyell Immunopharma (LYEL) has a 3-Year RORE % of -9.22 as of Jun. 2026. 3-Year RORE % shows how much a company earns by reinvesting its retained earnings in 3-year. View historical data on Lyell Immunopharma and its competitors. According to the industry distribution chart, Lyell Immunopharma ranks #624 out of 1296 companies in the Biotechnology industry, placing it in the top 48.1%.
Is Lyell Immunopharma's 3-Year RORE % too high?
Lyell Immunopharma's current 3-Year RORE % is -9.22. Based on the distribution chart, Lyell Immunopharma ranks #624 out of 1296 companies in the Biotechnology industry, which is above the industry midpoint. Overall, Lyell Immunopharma has a GF Score™ of 55/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Lyell Immunopharma's 3-Year RORE % compare to FHTX and ZNTL?
According to the Biotechnology industry distribution chart, Lyell Immunopharma ranks #624 out of 1296 companies for 3-Year RORE %. This puts Lyell Immunopharma in the upper half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good 3-Year RORE % for a Biotechnology company?
A good 3-Year RORE % depends on the Biotechnology industry context. However, 3-Year RORE % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high 3-Year RORE % mean?
A high 3-Year RORE % can signal that a stock is expensive relative to its fundamentals. 3-Year RORE % shows how much a company earns by reinvesting its retained earnings in 3-year. View historical data on Lyell Immunopharma and its competitors. Lyell Immunopharma's current 3-Year RORE % is -9.22. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Lyell Immunopharma stock overvalued right now?
Based on GuruFocus' analysis, Lyell Immunopharma (LYEL) is currently considered Significantly Overvalued. The stock's GF Value™ is $3.71, compared to a current price of $14.53 — trading 291.6% above its estimated fair value. The current 3-Year RORE % is -9.22. Lyell Immunopharma's overall GF Score™ is 55/100 with 6 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is 3-Year RORE % calculated?
3-Year RORE % is calculated from a company's financial statements. For Lyell Immunopharma (LYEL), the current 3-Year RORE % is -9.22 as of Jun. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is Lyell Immunopharma (LYEL) Overvalued in 2026?

Based on GuruFocus' analysis, Lyell Immunopharma stock appears to be overvalued. The current stock price of $14.53 is trading 291.6% above its estimated GF Value™ of $3.71. GuruFocus considers Lyell Immunopharma to be Significantly Overvalued.

Key valuation signals for LYEL:

  • 3-Year RORE %: -9.22
  • GF Value™: $3.71 vs. price of $14.53 (291.6% above fair value)
  • GF Score™: 55/100 with 6 warning signs

No single metric tells the full story. See the LYEL stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


Lyell Immunopharma Business Description

Address 201 Haskins Way, South San Francisco, CA, USA, 94080
Lyell Immunopharma Inc s a late-stage clinical cell therapy company advancing a pipeline of proprietary next-generation autologous chimeric antigen receptor (CAR) T-cell product candidates for patients with hematologic malignancies and solid tumors. The Company's product candidate, rondecabtagene autoleucel (ronde-cel, also known as LYL314), is an autologous dual-targeting CD19/CD20 CAR T-cell therapy in development for large B-cell lymphoma (LBCL). The Company has recently acquired exclusive rights outside of mainland China, Hong Kong, Macau and Taiwan, to a novel guanylyl cyclase C (GCC)-targeted CAR T-cell product candidate in early clinical development for refractory metastatic colorectal cancer (mCRC) and other GCC-expressing cancers.
55GF Score

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3-Year RORE % is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

$14.53
Price
$3.71
GF Value