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Lyell ImmunopharmaLYEL +2.62%53 Return-on-Tangible-Equity is -37.03% as of Mar. 2026. GuruFocus rates LYEL with a GF Score™ of 53/100 and a GF Value™ of $5.24 (Significantly Overvalued). The stock has 6 warning signs investors should review. Among 1,199 Biotechnology companies, Lyell Immunopharma ranks worse than 68.89% on this metric.
Return-on-Tangible-Equity is calculated as Net Income divided by its average total shareholder tangible equity. Total shareholder tangible equity equals to Total Stockholders Equity minus Intangible Assets. Lyell Immunopharma's annualized net income for the quarter that ended in Mar. 2026 was $-96.61 Mil. Lyell Immunopharma's average shareholder tangible equity for the quarter that ended in Mar. 2026 was $260.93 Mil. Therefore, Lyell Immunopharma's annualized Return-on-Tangible-Equity for the quarter that ended in Mar. 2026 was -37.03%.
The historical rank and industry rank for Lyell Immunopharma's Return-on-Tangible-Equity or its related term are showing as below:
LYEL'
s Return-on-Tangible-Equity Range Over the Past 10 Years
Min: -86.98 Med: -31.71 Max: -20.77
Current: -82.89
During the past 7 years, Lyell Immunopharma's highest Return-on-Tangible-Equity was -20.77%. The lowest was -86.98%. And the median was -31.71%.
LYEL's Return-on-Tangible-Equity is ranked worse than 68.89% of 1199
companies
in the Biotechnology industry
Industry Median: -42.4
vs LYEL: -82.89
Return-on-Tangible-Equity measures the rate of return on the ownership interest (shareholder's tangible equity) of the common stock owners. It measures a firm's efficiency at generating profits from every unit of shareholders' tangible equity (shareholders equity minus intangibles). Return-on-Tangible-Equity shows how well a company uses investment funds to generate earnings growth. Return-on-Tangible-Equitys between 15% and 20% are considered desirable.
Be Aware
Net Income is used.
Because a company can increase its Return-on-Tangible-Equity by having more financial leverage, it is important to watch the leverage ratio when investing in high Return-on-Tangible-Equity companies. Like Return-on-Tangible-Asset, Return-on-Tangible-Equity is calculated with only 12 months data. Fluctuations in company's earnings or business cycles can affect the ratio drastically. It is important to look at the ratio from a long term perspective.
Asset light businesses require very few assets to generate very high earnings. Their Return-on-Tangible-Equitys can be extremely high.
Lyell Immunopharma Return-on-Tangible-Equity Related Terms
Lyell Immunopharma Return-on-Tangible-Equity Historical Data
* Premium members only.
The historical data trend for Lyell Immunopharma's Return-on-Tangible-Equity can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
LYEL vs ZNTL, PROK, VNDA: Return-on-Tangible-Equity Comparison
For the Biotechnology subindustry, Lyell Immunopharma's Return-on-Tangible-Equity, along with its competitors' market caps and Return-on-Tangible-Equity data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Lyell Immunopharma Return-on-Tangible-Equity vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Lyell Immunopharma's Return-on-Tangible-Equity distribution charts can be found below:
* The bar in red indicates where Lyell Immunopharma's Return-on-Tangible-Equity falls into.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
In the calculation of annual Return-on-Tangible-Equity, the net income of the last fiscal year and the average total shareholder tangible equity over the fiscal year are used. In calculating the quarterly data,
the net income data used here is four times the quarterly (Mar. 2026) net income data.
Return-on-Tangible-Equity is displayed in the 10-year financial page.
What does a Return-on-Tangible-Equity of -37.03% mean?
Lyell Immunopharma (LYEL) has a Return-on-Tangible-Equity of -37.03% as of Mar. 2026. Return on tangible equity is the ratio of current-period net income to average two-period tangible equity. View historical data on Lyell Immunopharma and its competitors. According to the industry distribution chart, Lyell Immunopharma ranks #826 out of 1199 companies in the Biotechnology industry, placing it in the top 68.9%.
Is Lyell Immunopharma's Return-on-Tangible-Equity too high?
Lyell Immunopharma's current Return-on-Tangible-Equity is -37.03%. Based on the distribution chart, Lyell Immunopharma ranks #826 out of 1199 companies in the Biotechnology industry, which is below the industry midpoint. Overall, Lyell Immunopharma has a GF Score™ of 53/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Lyell Immunopharma's Return-on-Tangible-Equity compare to ZNTL and PROK?
According to the Biotechnology industry distribution chart, Lyell Immunopharma ranks #826 out of 1199 companies for Return-on-Tangible-Equity. This places Lyell Immunopharma in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Return-on-Tangible-Equity for a Biotechnology company?
A good Return-on-Tangible-Equity depends on the Biotechnology industry context. However, Return-on-Tangible-Equity should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Return-on-Tangible-Equity mean?
A high Return-on-Tangible-Equity can signal that a stock is expensive relative to its fundamentals. Return on tangible equity is the ratio of current-period net income to average two-period tangible equity. View historical data on Lyell Immunopharma and its competitors. Lyell Immunopharma's current Return-on-Tangible-Equity is -37.03%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Lyell Immunopharma stock overvalued right now?
Based on GuruFocus' analysis, Lyell Immunopharma (LYEL) is currently considered Significantly Overvalued. The stock's GF Value™ is $5.24, compared to a current price of $13.30 — trading 153.7% above its estimated fair value. The current Return-on-Tangible-Equity is -37.03%. Lyell Immunopharma's overall GF Score™ is 53/100 with 6 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Return-on-Tangible-Equity calculated?
Return-on-Tangible-Equity is calculated from a company's financial statements. For Lyell Immunopharma (LYEL), the current Return-on-Tangible-Equity is -37.03% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is Lyell Immunopharma (LYEL) Overvalued in 2026?
Based on GuruFocus' analysis, Lyell Immunopharma stock appears to be overvalued.
The current stock price of $13.30 is trading 153.7% above its estimated GF Value™ of $5.24.
GuruFocus considers Lyell Immunopharma to be Significantly Overvalued.
Key valuation signals for LYEL:
Return-on-Tangible-Equity: -37.03%
GF Value™: $5.24 vs. price of $13.30 (153.7% above fair value)
No single metric tells the full story. See the LYEL stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
Lyell Immunopharma Inc s a late-stage clinical cell therapy company advancing a pipeline of proprietary next-generation autologous chimeric antigen receptor (CAR) T-cell product candidates for patients with hematologic malignancies and solid tumors. The Company's product candidate, rondecabtagene autoleucel (ronde-cel, also known as LYL314), is an autologous dual-targeting CD19/CD20 CAR T-cell therapy in development for large B-cell lymphoma (LBCL). The Company has recently acquired exclusive rights outside of mainland China, Hong Kong, Macau and Taiwan, to a novel guanylyl cyclase C (GCC)-targeted CAR T-cell product candidate in early clinical development for refractory metastatic colorectal cancer (mCRC) and other GCC-expressing cancers.
53GF Score
Get the complete analysis for LYEL
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