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SymBio PharmaceuticalsTSE:4582 +1.43%36 Cyclically Adjusted PB Ratio is 0.30 as of Aug. 05, 2026, which is 59% below its 10-year median of 0.74. GuruFocus rates TSE:4582 with a GF Score™ of 36/100 and a GF Value™ of 円60.08 (Modestly Overvalued). The stock has 6 warning signs investors should review. Among 737 Drug Manufacturers companies, SymBio Pharmaceuticals ranks better than 92.67% on this metric.
The historical rank and industry rank for SymBio Pharmaceuticals's Cyclically Adjusted PB Ratio or its related term are showing as below:
TSE:4582'
s Cyclically Adjusted PB Ratio Range Over the Past 10 Years
Min: 0.29 Med: 0.74 Max: 3.8
Current: 0.29
During the past years, SymBio Pharmaceuticals's highest Cyclically Adjusted PB Ratio was 3.80. The lowest was 0.29. And the median was 0.74.
TSE:4582's Cyclically Adjusted PB Ratio is ranked better than 92.67% of 737
companies
in the Drug Manufacturers industry
Industry Median: 1.77
vs TSE:4582: 0.29
The Shiller PE Ratio was first used by professor Robert Shiller. He uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings per share of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio. The Cyclically Adjusted Book per Share is the average of the inflation adjusted book value per share of a company over the past 10 years.
SymBio Pharmaceuticals's adjusted book value per share data for the three months ended in Dec. 2025 was 円21.387. Add all the adjusted book value per share for the past 10 years together and divide the count will get our Cyclically Adjusted Book per Share, which is 円238.49 for the trailing ten years ended in Dec. 2025.
Shiller PE for Stocks: The True Measure of Stock Valuation
SymBio Pharmaceuticals (TSE:4582) Cyclically Adjusted PB Ratio Explanation
Compared with the regular PB Ratio, which works poorly for cyclical businesses, the Cyclically Adjusted PB Ratio smoothed out the fluctuations of book value during business cycles. Therefore it is more accurate in reflecting the valuation of the company.
If a company has consistent business performance, the Cyclically Adjusted PB Ratio should give similar results to regular PB Ratio.
SymBio Pharmaceuticals Cyclically Adjusted PB Ratio Related Terms
SymBio Pharmaceuticals Cyclically Adjusted PB Ratio Historical Data
* Premium members only.
The historical data trend for SymBio Pharmaceuticals's Cyclically Adjusted PB Ratio can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
SymBio Pharmaceuticals Cyclically Adjusted PB Ratio Chart
TSE:4582 vs ZTS: Cyclically Adjusted PB Ratio Comparison
For the Drug Manufacturers - Specialty & Generic subindustry, SymBio Pharmaceuticals's Cyclically Adjusted PB Ratio, along with its competitors' market caps and Cyclically Adjusted PB Ratio data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
SymBio Pharmaceuticals Cyclically Adjusted PB Ratio vs Drug Manufacturers Industry
For the Drug Manufacturers industry and Healthcare sector, SymBio Pharmaceuticals's Cyclically Adjusted PB Ratio distribution charts can be found below:
* The bar in red indicates where SymBio Pharmaceuticals's Cyclically Adjusted PB Ratio falls into.
SymBio Pharmaceuticals Cyclically Adjusted PB Ratio Calculation
Like the Shiller PE Ratio, the Cyclically Adjusted PB Ratio takes the Book Value per Share from the past 10 years, adjusts it for inflation, and then calculates the average. This average is then used for the P/B calculation. Because it considers this 10-year average, it's often referred to as the CAPB Ratio.
The Shiller PE Ratio was first used by professor Robert Shiller to measure the valuation of the overall market. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.
What does a Cyclically Adjusted PB Ratio of 0.30 mean?
SymBio Pharmaceuticals (TSE:4582) has a Cyclically Adjusted PB Ratio of 0.30 as of Aug. 05, 2026. Cyclically Adjusted PB Ratio is the ratio of share price to a company's inflation-adjusted book value per share over a 10-year period. View historical data on SymBio Pharmaceuticals and its competitors. This is 59% below median its historical median of 0.74. Over the past decade, SymBio Pharmaceuticals' Cyclically Adjusted PB Ratio has ranged from 0.29 to 3.80. According to the industry distribution chart, SymBio Pharmaceuticals ranks #54 out of 737 companies in the Drug Manufacturers industry, placing it in the top 7.3%.
Is SymBio Pharmaceuticals' Cyclically Adjusted PB Ratio too high?
SymBio Pharmaceuticals' current Cyclically Adjusted PB Ratio of 0.30 is 59% below median its 10-year median of 0.74. Over the past 10 years, this metric has ranged from a low of 0.29 to a high of 3.80. The Drug Manufacturers industry median Cyclically Adjusted PB Ratio is 1.77. SymBio Pharmaceuticals' value of 0.30 is 83.1% below this industry median. Based on the distribution chart, SymBio Pharmaceuticals ranks #54 out of 737 companies in the Drug Manufacturers industry, which is in the top quartile — a strong position relative to peers. Overall, SymBio Pharmaceuticals has a GF Score™ of 36/100 and is considered Modestly Overvalued, reflecting its overall financial health beyond just this single metric.
How does SymBio Pharmaceuticals' Cyclically Adjusted PB Ratio compare to ZTS?
According to the Drug Manufacturers industry distribution chart, SymBio Pharmaceuticals ranks #54 out of 737 companies for Cyclically Adjusted PB Ratio. This places SymBio Pharmaceuticals in the top 7% of its industry — outperforming the majority of peers. The industry median Cyclically Adjusted PB Ratio is 1.77. SymBio Pharmaceuticals' value of 0.30 is 83.1% below this benchmark. Historically, SymBio Pharmaceuticals' own Cyclically Adjusted PB Ratio has ranged from 0.29 to 3.80 over the past decade. While the company's 10-year median is 0.74 vs. the industry median of 1.77, SymBio Pharmaceuticals has consistently been below the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Cyclically Adjusted PB Ratio for a Drug Manufacturers company?
The median Cyclically Adjusted PB Ratio among Drug Manufacturers companies is 1.77, based on 737 companies in the industry. Companies in the top quartile (top 25%) have a Cyclically Adjusted PB Ratio significantly above this median, while those in the bottom quartile fall well below. However, Cyclically Adjusted PB Ratio should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. SymBio Pharmaceuticals's current Cyclically Adjusted PB Ratio of 0.30 is 83.1% below the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Cyclically Adjusted PB Ratio mean?
A high Cyclically Adjusted PB Ratio can signal that a stock is expensive relative to its fundamentals. Cyclically Adjusted PB Ratio is the ratio of share price to a company's inflation-adjusted book value per share over a 10-year period. View historical data on SymBio Pharmaceuticals and its competitors. For the Drug Manufacturers industry, the median Cyclically Adjusted PB Ratio is 1.77 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. SymBio Pharmaceuticals's current Cyclically Adjusted PB Ratio is 0.30, which is 59% below median its own 10-year median of 0.74. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is SymBio Pharmaceuticals stock overvalued right now?
Based on GuruFocus' analysis, SymBio Pharmaceuticals (TSE:4582) is currently considered Modestly Overvalued. The stock's GF Value™ is 円60.08, compared to a current price of 円71.00 — trading 18.2% above its estimated fair value. The current Cyclically Adjusted PB Ratio is 0.30, which is 59% below median its 10-year median of 0.74 and 83.1% below the Drug Manufacturers industry median of 1.77. SymBio Pharmaceuticals' overall GF Score™ is 36/100 with 6 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Cyclically Adjusted PB Ratio calculated?
Cyclically Adjusted PB Ratio is calculated from a company's financial statements. For SymBio Pharmaceuticals (TSE:4582), the current Cyclically Adjusted PB Ratio is 0.30 as of Aug. 05, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is SymBio Pharmaceuticals (TSE:4582) Overvalued in 2026?
Based on GuruFocus' analysis, SymBio Pharmaceuticals stock appears to be overvalued.
The current stock price of 円71.00 is trading 18.2% above its estimated GF Value™ of 円60.08.
GuruFocus considers SymBio Pharmaceuticals to be Modestly Overvalued.
Key valuation signals for TSE:4582:
Cyclically Adjusted PB Ratio: 0.30 (59% below median its 10-year median of 0.74)
GF Value™: 円60.08 vs. price of 円71.00 (18.2% above fair value)
Industry Position: 83.1% below the Drug Manufacturers median (#54 of 737)
No single metric tells the full story. See the TSE:4582 stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
SymBio Pharmaceuticals Ltd is a biopharmaceutical company engaged in development of new drugs with a primary focus on the treatment of rare diseases, mainly in the areas of oncology, hematology and multiple viral infections, and conduct integrated business activities that encompass search for new drug candidates, development, manufacturing, and sales.
36GF Score
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