SymBio Pharmaceuticals (TSE:4582) Cyclically Adjusted Book per Share: 円238.49 (As of Dec. 2025)

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TSE:4582 SymBio Pharmaceuticals Ltd TSE:4582
35 GF Score
Price 円70.00
GF Value 円60.86
Valuation Modestly Overvalued
! 6 Warning Signs
View Full Analysis

What is SymBio Pharmaceuticals Cyclically Adjusted Book per Share?

SymBio Pharmaceuticals TSE:4582 35 Cyclically Adjusted Book per Share is 円238.49 as of Dec. 2025. GuruFocus rates TSE:4582 with a GF Score™ of 35/100 and a GF Value™ of 円60.86 (Modestly Overvalued). The stock has 6 warning signs investors should review.

E10 is a concept invented by Prof. Robert Shiller, who uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted Book per Share and the Cyclically Adjusted PB Ratio. The Cyclically Adjusted Book per Share is the average of the inflation adjusted Book Value per Share of a company over the past 10 years.

SymBio Pharmaceuticals's adjusted book value per share for the three months ended in Dec. 2025 was 円21.387. Add all the adjusted book value per share for the past 10 years together and divide the count will get our Cyclically Adjusted Book per Share, which is 円238.49 for the trailing ten years ended in Dec. 2025.

During the past 12 months, SymBio Pharmaceuticals's average Cyclically Adjusted Book Growth Rate was -23.70% per year. During the past 3 years, the average Cyclically Adjusted Book Growth Rate was -19.40% per year. During the past 5 years, the average Cyclically Adjusted Book Growth Rate was -18.10% per year. Please click Growth Rate Calculation Example (GuruFocus) to see how GuruFocus calculates Wal-Mart Stores Inc (WMT)'s revenue growth rate. You can apply the same method to get the Cyclically Adjusted Book Growth Rate using Cyclically Adjusted Book per Share data.

During the past 13 years, the highest 3-Year average Cyclically Adjusted Book Growth Rate of SymBio Pharmaceuticals was -16.60% per year. The lowest was -19.40% per year. And the median was -17.35% per year.

As of today (2026-07-15), SymBio Pharmaceuticals's current stock price is 円70.00. SymBio Pharmaceuticals's Cyclically Adjusted Book per Share for the quarter that ended in Dec. 2025 was 円238.49. SymBio Pharmaceuticals's Cyclically Adjusted PB Ratio of today is 0.29.

During the past 13 years, the highest Cyclically Adjusted PB Ratio of SymBio Pharmaceuticals was 3.80. The lowest was 0.29. And the median was 0.74.


SymBio Pharmaceuticals  (TSE:4582) Cyclically Adjusted Book per Share Explanation

If a company grows much fast than inflation, Cyclically Adjusted Book per Share may underestimate the company's equity. Cyclically Adjusted PB Ratio can seem to be too high even the actual PB Ratio is low.

For the Cyclically Adjusted PB Ratio, the book value of the past 10 years are inflation-adjusted and averaged. The result is used for P/B calculation. Since it looks at the average over the last 10 years, the Cyclically Adjusted PB Ratio is also called CAPB Ratio.

The Shiller PE Ratio was first used by professor Robert Shiller. He uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings per share of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio. The Cyclically Adjusted Book per Share is the average of the inflation adjusted book value per share of a company over the past 10 years.

SymBio Pharmaceuticals's Cyclically Adjusted PB Ratio of today is calculated as

Cyclically Adjusted PB Ratio=Share Price/Cyclically Adjusted Book per Share
=70.00/238.49
=0.29

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

During the past 13 years, the highest Cyclically Adjusted PB Ratio of SymBio Pharmaceuticals was 3.80. The lowest was 0.29. And the median was 0.74.


Be Aware

Cyclically Adjusted PB Ratio works better for cyclical companies. It gives you a better idea on the company's real book value.


SymBio Pharmaceuticals Cyclically Adjusted Book per Share Related Terms


SymBio Pharmaceuticals Cyclically Adjusted Book per Share Historical Data

* Premium members only.

The historical data trend for SymBio Pharmaceuticals's Cyclically Adjusted Book per Share can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

SymBio Pharmaceuticals Cyclically Adjusted Book per Share Chart

SymBio Pharmaceuticals Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
Cyclically Adjusted Book per Share
Get a 7-Day Free Trial Premium Member Only Premium Member Only 539.34 454.91 380.50 312.40 238.49

SymBio Pharmaceuticals Quarterly Data
Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
Cyclically Adjusted Book per Share Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only 291.75 271.80 251.86 238.49 0.00

TSE:4582 vs ZTS, UTHR: Cyclically Adjusted Book per Share Comparison

For the Drug Manufacturers - Specialty & Generic subindustry, SymBio Pharmaceuticals's Cyclically Adjusted PB Ratio, along with its competitors' market caps and Cyclically Adjusted PB Ratio data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


SymBio Pharmaceuticals Cyclically Adjusted PB Ratio vs Drug Manufacturers Industry

For the Drug Manufacturers industry and Healthcare sector, SymBio Pharmaceuticals's Cyclically Adjusted PB Ratio distribution charts can be found below:

* The bar in red indicates where SymBio Pharmaceuticals's Cyclically Adjusted PB Ratio falls into.


TSE:4582
35GF Score
SymBio Pharmaceuticals Ltd TSE:4582
Cyclically Adjusted Book per Share is just one metric. See GF Score™, valuation, warning signs, and more.
View Full Analysis

SymBio Pharmaceuticals Cyclically Adjusted Book per Share Calculation

E10 is a concept invented by Prof. Robert Shiller, who uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted Book per Share and the Cyclically Adjusted PB Ratio. The Cyclically Adjusted Book per Share is the average of the inflation adjusted Book Value per Share of a company over the past 10 years.

What is Cyclically Adjusted Book per Share? How do we calculate Cyclically Adjusted Book per Share?

Cyclically Adjusted Book per Share is the average of the inflation adjusted Book Value per Share of a company over the past 10 years. Let's use an example to explain.

If we want to calculate the Cyclically Adjusted Book per Share of Wal-Mart (WMT) for Dec. 31, 2010, we need to have the inflation data and the book value per share from 2001 through 2010.

We adjusted the 2001 book value per share data with the total inflation from 2001 through 2010 to the equivalent book value in 2010. If the total inflation from 2001 to 2010 is 40%, and Wal-Mart's book value is $1 a share in 2001, then the 2001's equivalent book value in 2010 is $1.4 a share. If Wal-Mart's book value is $1 again in 2002, and the total inflation from 2002 through 2010 is 35%, then the equivalent 2002 book value in 2010 is $1.35. So on and so forth, you get the equivalent book value per share of past 10 years. Then you add them together and divided the sum by the count to get Cyclically Adjusted Book per Share.

Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.

For example, SymBio Pharmaceuticals's adjusted Book Value per Share data for the three months ended in Dec. 2025 was:

Adj_Book= Book Value per Share /CPI of Dec. 2025 (Change)*Current CPI (Dec. 2025)
=21.387/113.0000*113.0000
=21.387

Current CPI (Dec. 2025) = 113.0000.

SymBio Pharmaceuticals Quarterly Data

Book Value per Share CPI Adj_Book
201603 469.863 97.900 542.334
201606 527.127 98.100 607.190
201609 495.264 98.000 571.070
201612 471.492 98.400 541.449
201703 445.258 98.100 512.886
201706 391.597 98.500 449.243
201709 232.142 98.800 265.507
201712 239.743 99.400 272.545
201803 230.178 99.200 262.199
201806 223.218 99.200 254.271
201809 242.383 99.900 274.167
201812 237.951 99.700 269.694
201903 217.024 99.700 245.975
201906 222.730 99.800 252.189
201909 158.813 100.100 179.279
201912 166.576 100.500 187.294
202003 157.256 100.300 177.168
202006 164.750 99.900 186.354
202009 142.017 99.900 160.640
202012 122.006 99.300 138.839
202103 116.144 99.900 131.374
202106 115.904 99.500 131.630
202109 130.399 100.100 147.204
202112 175.783 100.100 198.436
202203 178.316 101.100 199.305
202206 212.278 101.800 235.633
202209 224.199 103.100 245.727
202212 215.246 104.100 233.648
202303 215.450 104.400 233.198
202306 210.742 105.200 226.367
202309 193.071 106.200 205.433
202312 170.891 106.800 180.812
202403 156.378 107.200 164.839
202406 140.727 108.200 146.970
202409 0.000 108.900 0.000
202412 91.574 110.700 93.477
202503 71.044 111.100 72.259
202506 48.504 111.700 49.069
202509 33.887 112.000 34.190
202512 21.387 113.000 21.387

Add all the adjusted book value per share together and divide the count will get our Cyclically Adjusted Book per Share.

What does a Cyclically Adjusted Book per Share of 円238.49 mean?
SymBio Pharmaceuticals (TSE:4582) has a Cyclically Adjusted Book per Share of 円238.49 as of Dec. 2025. Cyclically adjusted book value per share represents the company's inflation-adjusted book value per share over a 10-year period. View historical data on SymBio Pharmaceuticals and its competitors.
Is SymBio Pharmaceuticals' Cyclically Adjusted Book per Share too high?
SymBio Pharmaceuticals' current Cyclically Adjusted Book per Share is 円238.49. Overall, SymBio Pharmaceuticals has a GF Score™ of 35/100 and is considered Modestly Overvalued, reflecting its overall financial health beyond just this single metric.
How does SymBio Pharmaceuticals' Cyclically Adjusted Book per Share compare to ZTS and UTHR?
SymBio Pharmaceuticals' Cyclically Adjusted Book per Share of 円238.49 can be compared against companies in the Drug Manufacturers industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Cyclically Adjusted Book per Share for a Drug Manufacturers company?
A good Cyclically Adjusted Book per Share depends on the Drug Manufacturers industry context. However, Cyclically Adjusted Book per Share should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Cyclically Adjusted Book per Share mean?
A high Cyclically Adjusted Book per Share can signal that a stock is expensive relative to its fundamentals. Cyclically adjusted book value per share represents the company's inflation-adjusted book value per share over a 10-year period. View historical data on SymBio Pharmaceuticals and its competitors. SymBio Pharmaceuticals's current Cyclically Adjusted Book per Share is 円238.49. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is SymBio Pharmaceuticals stock overvalued right now?
Based on GuruFocus' analysis, SymBio Pharmaceuticals (TSE:4582) is currently considered Modestly Overvalued. The stock's GF Value™ is 円60.86, compared to a current price of 円70.00 — trading 15% above its estimated fair value. The current Cyclically Adjusted Book per Share is 円238.49. SymBio Pharmaceuticals' overall GF Score™ is 35/100 with 6 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Cyclically Adjusted Book per Share calculated?
Cyclically Adjusted Book per Share is calculated from a company's financial statements. For SymBio Pharmaceuticals (TSE:4582), the current Cyclically Adjusted Book per Share is 円238.49 as of Dec. 2025. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is SymBio Pharmaceuticals (TSE:4582) Overvalued in 2026?

Based on GuruFocus' analysis, SymBio Pharmaceuticals stock appears to be overvalued. The current stock price of 円70.00 is trading 15% above its estimated GF Value™ of 円60.86. GuruFocus considers SymBio Pharmaceuticals to be Modestly Overvalued.

Key valuation signals for TSE:4582:

  • Cyclically Adjusted Book per Share: 円238.49
  • GF Value™: 円60.86 vs. price of 円70.00 (15% above fair value)
  • GF Score™: 35/100 with 6 warning signs

No single metric tells the full story. See the TSE:4582 stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


SymBio Pharmaceuticals Business Description

Address 1-28 Toranomon 4-chome, 7th Floor, Toranomon Towers Office, Minato-ku, Tokyo, JPN, 105-0001
SymBio Pharmaceuticals Ltd is a biopharmaceutical company engaged in development of new drugs with a primary focus on the treatment of rare diseases, mainly in the areas of oncology, hematology and multiple viral infections, and conduct integrated business activities that encompass search for new drug candidates, development, manufacturing, and sales.
35GF Score

Get the complete analysis for TSE:4582

Cyclically Adjusted Book per Share is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

円70.00
Price
円60.86
GF Value