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Esperion TherapeuticsESPR -0.31%62 Cyclically Adjusted PS Ratio is 0.86 as of Aug. 04, 2026, which is 13% below its 10-year median of 0.99. GuruFocus rates ESPR with a GF Score™ of 62/100 and a GF Value™ of $2.30 (Significantly Overvalued). The stock has 6 warning signs investors should review. Among 749 Drug Manufacturers companies, Esperion Therapeutics ranks better than 73.43% on this metric.
The historical rank and industry rank for Esperion Therapeutics's Cyclically Adjusted PS Ratio or its related term are showing as below:
ESPR'
s Cyclically Adjusted PS Ratio Range Over the Past 10 Years
Min: 0.18 Med: 0.99 Max: 13.38
Current: 0.86
During the past years, Esperion Therapeutics's highest Cyclically Adjusted PS Ratio was 13.38. The lowest was 0.18. And the median was 0.99.
ESPR's Cyclically Adjusted PS Ratio is ranked better than 73.43% of 749
companies
in the Drug Manufacturers industry
Industry Median: 1.98
vs ESPR: 0.86
The Shiller PE Ratio was first used by professor Robert Shiller. He uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings per share of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PS Ratio. The Cyclically Adjusted Revenue per Share is the average of the inflation adjusted revenue per share of a company over the past 10 years.
Esperion Therapeutics's adjusted revenue per share data for the three months ended in Mar. 2026 was $0.319. Add all the adjusted revenue per share for the past 10 years together and divide 10 will get our Cyclically Adjusted Revenue per Share, which is $3.71 for the trailing ten years ended in Mar. 2026.
Shiller PE for Stocks: The True Measure of Stock Valuation
Esperion Therapeutics (NAS:ESPR) Cyclically Adjusted PS Ratio Explanation
Compared with the regular PS Ratio, which works poorly for cyclical businesses, the Cyclically Adjusted PS Ratio smoothed out the fluctuations of revenue during business cycles. Therefore it is more accurate in reflecting the valuation of the company.
If a company has consistent business performance, the Cyclically Adjusted PS Ratio should give similar results to regular PS Ratio.
Esperion Therapeutics Cyclically Adjusted PS Ratio Related Terms
Esperion Therapeutics Cyclically Adjusted PS Ratio Historical Data
* Premium members only.
The historical data trend for Esperion Therapeutics's Cyclically Adjusted PS Ratio can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Esperion Therapeutics Cyclically Adjusted PS Ratio Chart
ESPR vs AMPH, NIKA, BIOA: Cyclically Adjusted PS Ratio Comparison
For the Drug Manufacturers - Specialty & Generic subindustry, Esperion Therapeutics's Cyclically Adjusted PS Ratio, along with its competitors' market caps and Cyclically Adjusted PS Ratio data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Esperion Therapeutics Cyclically Adjusted PS Ratio vs Drug Manufacturers Industry
For the Drug Manufacturers industry and Healthcare sector, Esperion Therapeutics's Cyclically Adjusted PS Ratio distribution charts can be found below:
* The bar in red indicates where Esperion Therapeutics's Cyclically Adjusted PS Ratio falls into.
Esperion Therapeutics Cyclically Adjusted PS Ratio Calculation
Like the Shiller PE Ratio, the Cyclically Adjusted PS Ratio takes the Revenue per Share from the past 10 years, adjusts it for inflation, and then calculates the average. This average is then used for the P/S calculation. Because it considers this 10-year average, it's often referred to as the CAPS Ratio.
The Shiller PE Ratio was first used by professor Robert Shiller to measure the valuation of the overall market. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PS Ratio.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.
What does a Cyclically Adjusted PS Ratio of 0.86 mean?
Esperion Therapeutics (ESPR) has a Cyclically Adjusted PS Ratio of 0.86 as of Aug. 04, 2026. Cyclically Adjusted PS Ratio is the ratio of share price to a company's inflation-adjusted revenue per share over a 10-year period. View historical data on Esperion Therapeutics and its competitors. This is 13% below median its historical median of 0.99. Over the past decade, Esperion Therapeutics' Cyclically Adjusted PS Ratio has ranged from 0.18 to 13.38. According to the industry distribution chart, Esperion Therapeutics ranks #199 out of 749 companies in the Drug Manufacturers industry, placing it in the top 26.6%.
Is Esperion Therapeutics' Cyclically Adjusted PS Ratio too high?
Esperion Therapeutics' current Cyclically Adjusted PS Ratio of 0.86 is 13% below median its 10-year median of 0.99. Over the past 10 years, this metric has ranged from a low of 0.18 to a high of 13.38. The Drug Manufacturers industry median Cyclically Adjusted PS Ratio is 1.98. Esperion Therapeutics' value of 0.86 is 56.6% below this industry median. Based on the distribution chart, Esperion Therapeutics ranks #199 out of 749 companies in the Drug Manufacturers industry, which is above the industry midpoint. Overall, Esperion Therapeutics has a GF Score™ of 62/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Esperion Therapeutics' Cyclically Adjusted PS Ratio compare to AMPH and NIKA?
According to the Drug Manufacturers industry distribution chart, Esperion Therapeutics ranks #199 out of 749 companies for Cyclically Adjusted PS Ratio. This puts Esperion Therapeutics in the upper half of its industry. The industry median Cyclically Adjusted PS Ratio is 1.98. Esperion Therapeutics' value of 0.86 is 56.6% below this benchmark. Historically, Esperion Therapeutics' own Cyclically Adjusted PS Ratio has ranged from 0.18 to 13.38 over the past decade. While the company's 10-year median is 0.99 vs. the industry median of 1.98, Esperion Therapeutics has consistently been below the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Cyclically Adjusted PS Ratio for a Drug Manufacturers company?
The median Cyclically Adjusted PS Ratio among Drug Manufacturers companies is 1.98, based on 749 companies in the industry. Companies in the top quartile (top 25%) have a Cyclically Adjusted PS Ratio significantly above this median, while those in the bottom quartile fall well below. However, Cyclically Adjusted PS Ratio should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Esperion Therapeutics's current Cyclically Adjusted PS Ratio of 0.86 is 56.6% below the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Cyclically Adjusted PS Ratio mean?
A high Cyclically Adjusted PS Ratio can signal that a stock is expensive relative to its fundamentals. Cyclically Adjusted PS Ratio is the ratio of share price to a company's inflation-adjusted revenue per share over a 10-year period. View historical data on Esperion Therapeutics and its competitors. For the Drug Manufacturers industry, the median Cyclically Adjusted PS Ratio is 1.98 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Esperion Therapeutics's current Cyclically Adjusted PS Ratio is 0.86, which is 13% below median its own 10-year median of 0.99. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Esperion Therapeutics stock overvalued right now?
Based on GuruFocus' analysis, Esperion Therapeutics (ESPR) is currently considered Significantly Overvalued. The stock's GF Value™ is $2.30, compared to a current price of $3.18 — trading 38.3% above its estimated fair value. The current Cyclically Adjusted PS Ratio is 0.86, which is 13% below median its 10-year median of 0.99 and 56.6% below the Drug Manufacturers industry median of 1.98. Esperion Therapeutics' overall GF Score™ is 62/100 with 6 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Cyclically Adjusted PS Ratio calculated?
Cyclically Adjusted PS Ratio is calculated from a company's financial statements. For Esperion Therapeutics (ESPR), the current Cyclically Adjusted PS Ratio is 0.86 as of Aug. 04, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is Esperion Therapeutics (ESPR) Overvalued in 2026?
Based on GuruFocus' analysis, Esperion Therapeutics stock appears to be overvalued.
The current stock price of $3.18 is trading 38.3% above its estimated GF Value™ of $2.30.
GuruFocus considers Esperion Therapeutics to be Significantly Overvalued.
Key valuation signals for ESPR:
Cyclically Adjusted PS Ratio: 0.86 (13% below median its 10-year median of 0.99)
GF Value™: $2.30 vs. price of $3.18 (38.3% above fair value)
Industry Position: 56.6% below the Drug Manufacturers median (#199 of 749)
No single metric tells the full story. See the ESPR stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
Esperion Therapeutics Inc is a commercial-stage biopharmaceutical company currently focused on bringing new medicines to patients that address unmet medical needs. It has developed and is commercializing U.S. Food and Drug Administration, or FDA, approved oral, once-daily, non-statin medicines for patients who are at risk for cardiovascular disease (or CVD and are struggling with elevated low-density lipoprotein cholesterol, or LDL-C. The Company views its operations and manages its business in one operating segment, which is the business of researching, developing, and commercializing therapies for the treatment of patients with elevated LDL-C. The company depends almost entirely on the success of two products, the bempedoic acid tablet and the bempedoic acid/ezetimibe combination tablet.
62GF Score
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