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WAVE Life SciencesWVE -1.19%59 Cyclically Adjusted PS Ratio is 10.38 as of Jul. 30, 2026, which is 20% below its 10-year median of 13.04. GuruFocus rates WVE with a GF Score™ of 59/100 and a GF Value™ of $4.29 (Significantly Overvalued). The stock has 2 warning signs investors should review. Among 537 Biotechnology companies, WAVE Life Sciences ranks worse than 66.48% on this metric.
The historical rank and industry rank for WAVE Life Sciences's Cyclically Adjusted PS Ratio or its related term are showing as below:
WVE'
s Cyclically Adjusted PS Ratio Range Over the Past 10 Years
Min: 9.14 Med: 13.04 Max: 33.55
Current: 10.43
During the past years, WAVE Life Sciences's highest Cyclically Adjusted PS Ratio was 33.55. The lowest was 9.14. And the median was 13.04.
WVE's Cyclically Adjusted PS Ratio is ranked worse than 66.48% of 537
companies
in the Biotechnology industry
Industry Median: 5.65
vs WVE: 10.43
The Shiller PE Ratio was first used by professor Robert Shiller. He uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings per share of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PS Ratio. The Cyclically Adjusted Revenue per Share is the average of the inflation adjusted revenue per share of a company over the past 10 years.
WAVE Life Sciences's adjusted revenue per share data for the three months ended in Mar. 2026 was $0.191. Add all the adjusted revenue per share for the past 10 years together and divide 10 will get our Cyclically Adjusted Revenue per Share, which is $0.56 for the trailing ten years ended in Mar. 2026.
Shiller PE for Stocks: The True Measure of Stock Valuation
WAVE Life Sciences (NAS:WVE) Cyclically Adjusted PS Ratio Explanation
Compared with the regular PS Ratio, which works poorly for cyclical businesses, the Cyclically Adjusted PS Ratio smoothed out the fluctuations of revenue during business cycles. Therefore it is more accurate in reflecting the valuation of the company.
If a company has consistent business performance, the Cyclically Adjusted PS Ratio should give similar results to regular PS Ratio.
WAVE Life Sciences Cyclically Adjusted PS Ratio Related Terms
WAVE Life Sciences Cyclically Adjusted PS Ratio Historical Data
* Premium members only.
The historical data trend for WAVE Life Sciences's Cyclically Adjusted PS Ratio can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
WAVE Life Sciences Cyclically Adjusted PS Ratio Chart
WVE vs FBRX, SVRA, SPTX: Cyclically Adjusted PS Ratio Comparison
For the Biotechnology subindustry, WAVE Life Sciences's Cyclically Adjusted PS Ratio, along with its competitors' market caps and Cyclically Adjusted PS Ratio data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
WAVE Life Sciences Cyclically Adjusted PS Ratio vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, WAVE Life Sciences's Cyclically Adjusted PS Ratio distribution charts can be found below:
* The bar in red indicates where WAVE Life Sciences's Cyclically Adjusted PS Ratio falls into.
WAVE Life Sciences Cyclically Adjusted PS Ratio Calculation
Like the Shiller PE Ratio, the Cyclically Adjusted PS Ratio takes the Revenue per Share from the past 10 years, adjusts it for inflation, and then calculates the average. This average is then used for the P/S calculation. Because it considers this 10-year average, it's often referred to as the CAPS Ratio.
The Shiller PE Ratio was first used by professor Robert Shiller to measure the valuation of the overall market. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PS Ratio.
WAVE Life Sciences's Cyclically Adjusted PS Ratio for today is calculated as
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.
What does a Cyclically Adjusted PS Ratio of 10.38 mean?
WAVE Life Sciences (WVE) has a Cyclically Adjusted PS Ratio of 10.38 as of Jul. 30, 2026. Cyclically Adjusted PS Ratio is the ratio of share price to a company's inflation-adjusted revenue per share over a 10-year period. View historical data on WAVE Life Sciences and its competitors. This is 20% below median its historical median of 13.04. Over the past decade, WAVE Life Sciences' Cyclically Adjusted PS Ratio has ranged from 9.14 to 33.55. According to the industry distribution chart, WAVE Life Sciences ranks #357 out of 537 companies in the Biotechnology industry, placing it in the top 66.5%.
Is WAVE Life Sciences' Cyclically Adjusted PS Ratio too high?
WAVE Life Sciences' current Cyclically Adjusted PS Ratio of 10.38 is 20% below median its 10-year median of 13.04. Over the past 10 years, this metric has ranged from a low of 9.14 to a high of 33.55. The Biotechnology industry median Cyclically Adjusted PS Ratio is 5.65. WAVE Life Sciences' value of 10.38 is 83.7% above this industry median. Based on the distribution chart, WAVE Life Sciences ranks #357 out of 537 companies in the Biotechnology industry, which is below the industry midpoint. Overall, WAVE Life Sciences has a GF Score™ of 59/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does WAVE Life Sciences' Cyclically Adjusted PS Ratio compare to FBRX and SVRA?
According to the Biotechnology industry distribution chart, WAVE Life Sciences ranks #357 out of 537 companies for Cyclically Adjusted PS Ratio. This places WAVE Life Sciences in the lower half of its industry. The industry median Cyclically Adjusted PS Ratio is 5.65. WAVE Life Sciences' value of 10.38 is 83.7% above this benchmark. Historically, WAVE Life Sciences' own Cyclically Adjusted PS Ratio has ranged from 9.14 to 33.55 over the past decade. While the company's 10-year median is 13.04 vs. the industry median of 5.65, WAVE Life Sciences has consistently been above the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Cyclically Adjusted PS Ratio for a Biotechnology company?
The median Cyclically Adjusted PS Ratio among Biotechnology companies is 5.65, based on 537 companies in the industry. Companies in the top quartile (top 25%) have a Cyclically Adjusted PS Ratio significantly above this median, while those in the bottom quartile fall well below. However, Cyclically Adjusted PS Ratio should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. WAVE Life Sciences's current Cyclically Adjusted PS Ratio of 10.38 is 83.7% above the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Cyclically Adjusted PS Ratio mean?
A high Cyclically Adjusted PS Ratio can signal that a stock is expensive relative to its fundamentals. Cyclically Adjusted PS Ratio is the ratio of share price to a company's inflation-adjusted revenue per share over a 10-year period. View historical data on WAVE Life Sciences and its competitors. For the Biotechnology industry, the median Cyclically Adjusted PS Ratio is 5.65 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. WAVE Life Sciences's current Cyclically Adjusted PS Ratio is 10.38, which is 20% below median its own 10-year median of 13.04. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is WAVE Life Sciences stock overvalued right now?
Based on GuruFocus' analysis, WAVE Life Sciences (WVE) is currently considered Significantly Overvalued. The stock's GF Value™ is $4.29, compared to a current price of $5.82 — trading 35.5% above its estimated fair value. The current Cyclically Adjusted PS Ratio is 10.38, which is 20% below median its 10-year median of 13.04 and 83.7% above the Biotechnology industry median of 5.65. WAVE Life Sciences' overall GF Score™ is 59/100 with 2 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Cyclically Adjusted PS Ratio calculated?
Cyclically Adjusted PS Ratio is calculated from a company's financial statements. For WAVE Life Sciences (WVE), the current Cyclically Adjusted PS Ratio is 10.38 as of Jul. 30, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is WAVE Life Sciences (WVE) Overvalued in 2026?
Based on GuruFocus' analysis, WAVE Life Sciences stock appears to be overvalued.
The current stock price of $5.82 is trading 35.5% above its estimated GF Value™ of $4.29.
GuruFocus considers WAVE Life Sciences to be Significantly Overvalued.
Key valuation signals for WVE:
Cyclically Adjusted PS Ratio: 10.38 (20% below median its 10-year median of 13.04)
GF Value™: $4.29 vs. price of $5.82 (35.5% above fair value)
Industry Position: 83.7% above the Biotechnology median (#357 of 537)
No single metric tells the full story. See the WVE stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
WAVE Life Sciences Ltd is a clinical-stage biotechnology company focused on unlocking the broad potential of RNA medicines also known as oligonucleotides, targeting ribonucleic acid (RNA), to transform human health. RNA medicines platform, PRISM, combines multiple modalities, chemistry innovation, and deep insights into human genetics to deliver scientific breakthroughs that treat both rare and prevalent disorders. Its toolkit of RNA-targeting modalities includes RNA editing, antisense silencing, and RNA interference, providing capabilities for designing and sustainably delivering candidates that optimally address disease biology. Its programs are for rare and prevalent diseases, including alpha-1 antitrypsin deficiency, obesity, Duchenne muscular dystrophy, and Huntington's disease.
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