WVE (Wave Life Sciences) E10: $-3.52 (As of Jun. 2026)

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Director of Data and Quant Analytics at GuruFocus
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Founder & CEO of GuruFocus
Dr. Charlie Tian is the founder and CEO of GuruFocus.com, a leading global investment research platform established in 2004. With a Ph.D. in physics, Dr. Tian transitioned from science to finance, applying a data-driven, disciplined approach to value investing.

WVE Wave Life Sciences Inc WVE
60 GF Score
Price $5.04
GF Value $3.93
Valuation Modestly Overvalued
! 4 Warning Signs
View Full Analysis

What is Wave Life Sciences E10?

Wave Life Sciences WVE -2.52% 60 E10 is $-3.52 as of Jun. 2026. GuruFocus rates WVE with a GF Score™ of 60/100 and a GF Value™ of $3.93 (Modestly Overvalued). The stock has 4 warning signs investors should review.

E10 is a concept invented by Prof. Robert Shiller, who uses E10 for his Shiller P/E calculation. E10 is the average of the inflation adjusted earnings of a company over the past 10 years.

Wave Life Sciences's adjusted earnings per share data for the three months ended in Jun. 2026 was $-0.340. Add all the adjusted EPS for the past 10 years together and divide 10 will get our e10, which is $-3.52 for the trailing ten years ended in Jun. 2026.

Please click Growth Rate Calculation Example (GuruFocus) to see how GuruFocus calculates Wal-Mart Stores Inc (WMT)'s revenue growth rate. You can apply the same method to get the E10 growth rate using E10 data.

As of today (2026-08-29), Wave Life Sciences's current stock price is $5.04. Wave Life Sciences's E10 for the quarter that ended in Jun. 2026 was $-3.52. Wave Life Sciences's Shiller PE Ratio of today is .


Wave Life Sciences  (NAS:WVE) E10 Explanation

If a company grows much fast than inflation, E10 may underestimate the company's earnings power. Shiller PE Ratio can seem to be too high even the actual P/E is low.

For the Shiller P/E, the earnings of the past 10 years are inflation-adjusted and averaged. The result is used for P/E calculation. Since it looks at the average over the last 10 years, the Shiller P/E is also called PE10.

The Shiller P/E was first used by professor Robert Shiller to measure the valuation of the overall market. The same calculation is applied here to individual companies.


Be Aware

Shiller PE Ratio works better for cyclical companies. It gives you a better idea on the company's real earnings power.


Wave Life Sciences E10 Related Terms


Wave Life Sciences E10 Historical Data

* Premium members only.

The historical data trend for Wave Life Sciences's E10 can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Wave Life Sciences E10 Chart

Wave Life Sciences Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
E10
Get a 7-Day Free Trial Premium Member Only Premium Member Only 0.00 0.00 0.00 -3.40 -3.49

Wave Life Sciences Quarterly Data
Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26 Jun26
E10 Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -3.49 -3.51 -3.49 -3.52 -3.52

WVE vs FBRX, SVRA, SPTX: E10 Comparison

For the Biotechnology subindustry, Wave Life Sciences's Shiller PE Ratio, along with its competitors' market caps and Shiller PE Ratio data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Wave Life Sciences Shiller PE Ratio vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Wave Life Sciences's Shiller PE Ratio distribution charts can be found below:

* The bar in red indicates where Wave Life Sciences's Shiller PE Ratio falls into.


WVE
60GF Score
Wave Life Sciences Inc WVE
E10 is just one metric. See GF Score™, valuation, warning signs, and more.
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Wave Life Sciences E10 Calculation

E10 is a concept invented by Prof. Robert Shiller, who uses E10 for his Shiller P/E calculation. When we calculate the today's Shiller P/E ratio of a stock, we use today's price divided by E10.

What is E10? How do we calculate E10?

E10 is the average of the inflation adjusted earnings of a company over the past 10 years. Let's use an example to explain.

If we want to calculate the E10 of Wal-Mart (WMT) for Dec. 31, 2010, we need to have the inflation data and the earnings from 2001 through 2010.

We adjusted the earnings of 2001 earnings data with the total inflation from 2001 through 2010 to the equivalent earnings in 2010. If the total inflation from 2001 to 2010 is 40%, and Wal-Mart earned $1 a share in 2001, then the 2001's equivalent earnings in 2010 is $1.4 a share. If Wal-Mart earns $1 again in 2002, and the total inflation from 2002 through 2010 is 35%, then the equivalent 2002 earnings in 2010 is $1.35. So on and so forth, you get the equivalent earnings of past 10 years. Then you add them together and divided the sum by 10 to get E10.

Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.

For example, Wave Life Sciences's adjusted earnings per share data for the three months ended in Jun. 2026 was:

Adj_EPS= Earnings per Share (Diluted) /CPI of Jun. 2026 (Change)*Current CPI (Jun. 2026)
=-0.34/333.9520*333.9520
=-0.340

Current CPI (Jun. 2026) = 333.9520.

Wave Life Sciences Quarterly Data

per share eps CPI Adj_EPS
201609 -0.750 241.428 -1.037
201612 -0.800 241.432 -1.107
201703 -0.900 243.801 -1.233
201706 -0.910 244.955 -1.241
201709 -0.920 246.819 -1.245
201712 -1.120 246.524 -1.517
201803 -1.260 249.554 -1.686
201806 -1.230 251.989 -1.630
201809 -1.280 252.439 -1.693
201812 -1.280 251.233 -1.701
201903 -1.360 254.202 -1.787
201906 -1.220 256.143 -1.591
201909 -1.480 256.759 -1.925
201912 -1.650 256.974 -2.144
202003 -1.380 258.115 -1.785
202006 -1.150 257.797 -1.490
202009 -0.860 260.280 -1.103
202012 -0.590 260.474 -0.756
202103 -0.860 264.877 -1.084
202106 -0.780 271.696 -0.959
202109 -0.120 274.310 -0.146
202112 -0.610 278.802 -0.731
202203 -0.620 287.504 -0.720
202206 -0.620 296.311 -0.699
202209 -0.420 296.808 -0.473
202212 -0.470 296.797 -0.529
202303 -0.270 301.836 -0.299
202306 -0.200 305.109 -0.219
202309 0.070 307.789 0.076
202312 -0.150 306.746 -0.163
202403 -0.240 312.332 -0.257
202406 -0.250 314.175 -0.266
202409 -0.470 315.301 -0.498
202412 0.170 315.605 0.180
202503 -0.290 319.799 -0.303
202506 -0.310 322.561 -0.321
202509 -0.320 324.800 -0.329
202512 -0.300 324.054 -0.309
202603 -0.130 330.213 -0.131
202606 -0.340 333.952 -0.340

Add all the adjusted EPS together and divide 10 will get our e10.

Frequently Asked Questions Learn more about E10 →
What does a E10 of $-3.52 mean?
Wave Life Sciences (WVE) has a E10 of $-3.52 as of Jun. 2026. E10 represents the company's inflation-adjusted earnings per share over a 10-year period. View historical data on Wave Life Sciences and its competitors.
Is Wave Life Sciences' E10 too high?
Wave Life Sciences' current E10 is $-3.52. Overall, Wave Life Sciences has a GF Score™ of 60/100 and is considered Modestly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Wave Life Sciences' E10 compare to FBRX and SVRA?
Wave Life Sciences' E10 of $-3.52 can be compared against companies in the Biotechnology industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good E10 for a Biotechnology company?
A good E10 depends on the Biotechnology industry context. However, E10 should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high E10 mean?
A high E10 can signal that a stock is expensive relative to its fundamentals. E10 represents the company's inflation-adjusted earnings per share over a 10-year period. View historical data on Wave Life Sciences and its competitors. Wave Life Sciences's current E10 is $-3.52. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Wave Life Sciences stock overvalued right now?
Based on GuruFocus' analysis, Wave Life Sciences (WVE) is currently considered Modestly Overvalued. The stock's GF Value™ is $3.93, compared to a current price of $5.04 — trading 28.2% above its estimated fair value. The current E10 is $-3.52. Wave Life Sciences' overall GF Score™ is 60/100 with 4 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is E10 calculated?
E10 is calculated from a company's financial statements. For Wave Life Sciences (WVE), the current E10 is $-3.52 as of Jun. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is Wave Life Sciences (WVE) Overvalued in 2026?

Based on GuruFocus' analysis, Wave Life Sciences stock appears to be overvalued. The current stock price of $5.04 is trading 28.2% above its estimated GF Value™ of $3.93. GuruFocus considers Wave Life Sciences to be Modestly Overvalued.

Key valuation signals for WVE:

  • E10: $-3.52
  • GF Value™: $3.93 vs. price of $5.04 (28.2% above fair value)
  • GF Score™: 60/100 with 4 warning signs

No single metric tells the full story. See the WVE stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


Wave Life Sciences Business Description

Other Exchanges 1U5:Germany
Address 7 Straits View No. 12-00, Marina One East Tower, Singapore, SGP, 018936
WAVE Life Sciences Ltd is a clinical-stage biotechnology company focused on unlocking the broad potential of RNA medicines also known as oligonucleotides, targeting ribonucleic acid (RNA), to transform human health. RNA medicines platform, PRISM, combines multiple modalities, chemistry innovation, and deep insights into human genetics to deliver scientific breakthroughs that treat both rare and prevalent disorders. Its toolkit of RNA-targeting modalities includes RNA editing, antisense silencing, and RNA interference, providing capabilities for designing and sustainably delivering candidates that optimally address disease biology. Its programs are for rare and prevalent diseases, including alpha-1 antitrypsin deficiency, obesity, Duchenne muscular dystrophy, and Huntington's disease.
60GF Score

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E10 is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

$5.04
Price
$3.93
GF Value