Focused on building reliable datasets, financial models, and research tools for value-minded investors. Committed to turning complex data into practical guidance for value-investing and long-term wealth.
Dr. Charlie Tian is the founder and CEO of GuruFocus.com, a leading global investment research platform established in 2004. With a Ph.D. in physics, Dr. Tian transitioned from science to finance, applying a data-driven, disciplined approach to value investing.
Pliant TherapeuticsPLRX 31 Debt-to-Equity is 0.17 as of Mar. 2026, which is 42% above its 10-year median of 0.12. GuruFocus rates PLRX with a GF Score™ of 31/100. The stock has 2 warning signs investors should review. Among 966 Biotechnology companies, Pliant Therapeutics ranks worse than 50.93% on this metric.
A high debt to equity ratio generally means that a company has been aggressive in financing its growth with debt. This can result in volatile earnings as a result of the additional interest expense.
The historical rank and industry rank for Pliant Therapeutics's Debt-to-Equity or its related term are showing as below:
PLRX'
s Debt-to-Equity Range Over the Past 10 Years
Min: 0.02 Med: 0.12 Max: 0.3
Current: 0.17
During the past 8 years, the highest Debt-to-Equity Ratio of Pliant Therapeutics was 0.30. The lowest was 0.02. And the median was 0.12.
PLRX's Debt-to-Equity is ranked worse than 50.93% of 966
companies
in the Biotechnology industry
Industry Median: 0.16
vs PLRX: 0.17
Because a company can increase its ROE % by having more financial leverage, it is important to watch the leverage ratio when investing in high ROE % companies.
Pliant Therapeutics Debt-to-Equity Related Terms
Pliant Therapeutics Debt-to-Equity Historical Data
* Premium members only.
The historical data trend for Pliant Therapeutics's Debt-to-Equity can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
PLRX vs BYSI, MCRB, XBIT: Debt-to-Equity Comparison
For the Biotechnology subindustry, Pliant Therapeutics's Debt-to-Equity, along with its competitors' market caps and Debt-to-Equity data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Pliant Therapeutics Debt-to-Equity vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Pliant Therapeutics's Debt-to-Equity distribution charts can be found below:
* The bar in red indicates where Pliant Therapeutics's Debt-to-Equity falls into.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Pliant Therapeutics (PLRX) has a Debt-to-Equity of 0.17 as of Mar. 2026. Debt-to-Equity ratio represents the ratio of total debt to total company equity. View historical data on Pliant Therapeutics and its competitors. This is 42% above median its historical median of 0.12. Over the past decade, Pliant Therapeutics' Debt-to-Equity has ranged from 0.02 to 0.30. According to the industry distribution chart, Pliant Therapeutics ranks #492 out of 966 companies in the Biotechnology industry, placing it in the top 50.9%.
Is Pliant Therapeutics' Debt-to-Equity too high?
Pliant Therapeutics' current Debt-to-Equity of 0.17 is 42% above median its 10-year median of 0.12. Over the past 10 years, this metric has ranged from a low of 0.02 to a high of 0.30. The Biotechnology industry median Debt-to-Equity is 0.16. Pliant Therapeutics' value of 0.17 is 6.3% above this industry median. Based on the distribution chart, Pliant Therapeutics ranks #492 out of 966 companies in the Biotechnology industry, which is below the industry midpoint. Overall, Pliant Therapeutics has a GF Score™ of 31/100, reflecting its overall financial health beyond just this single metric.
How does Pliant Therapeutics' Debt-to-Equity compare to BYSI and MCRB?
According to the Biotechnology industry distribution chart, Pliant Therapeutics ranks #492 out of 966 companies for Debt-to-Equity. This places Pliant Therapeutics in the lower half of its industry. The industry median Debt-to-Equity is 0.16. Pliant Therapeutics' value of 0.17 is 6.3% above this benchmark. Historically, Pliant Therapeutics' own Debt-to-Equity has ranged from 0.02 to 0.30 over the past decade. While the company's 10-year median is 0.12 vs. the industry median of 0.16, Pliant Therapeutics has consistently been above the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Debt-to-Equity for a Biotechnology company?
The median Debt-to-Equity among Biotechnology companies is 0.16, based on 966 companies in the industry. Companies in the top quartile (top 25%) have a Debt-to-Equity significantly above this median, while those in the bottom quartile fall well below. However, Debt-to-Equity should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Pliant Therapeutics's current Debt-to-Equity of 0.17 is 6.3% above the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Debt-to-Equity mean?
A high Debt-to-Equity can signal that a stock is expensive relative to its fundamentals. Debt-to-Equity ratio represents the ratio of total debt to total company equity. View historical data on Pliant Therapeutics and its competitors. For the Biotechnology industry, the median Debt-to-Equity is 0.16 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Pliant Therapeutics's current Debt-to-Equity is 0.17, which is 42% above median its own 10-year median of 0.12. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Pliant Therapeutics stock overvalued right now?
Pliant Therapeutics (PLRX) has a current Debt-to-Equity of 0.17. The current Debt-to-Equity is 0.17, which is 42% above median its 10-year median of 0.12 and 6.3% above the Biotechnology industry median of 0.16. Pliant Therapeutics' overall GF Score™ is 31/100 with 2 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Debt-to-Equity calculated?
Debt-to-Equity is calculated from a company's financial statements. For Pliant Therapeutics (PLRX), the current Debt-to-Equity is 0.17 as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Pliant Therapeutics Inc is a clinical-stage biopharmaceutical company engaged in the discovery and development of integrin-based therapies. The company operates as a single reportable segment focused on developing and commercializing novel integrin-based treatments. Its lead product candidate, PLN-101095, is an oral small molecule targeting integrins for the treatment of solid tumors. The company also advances a pipeline of integrin-based programs across multiple disease areas through its proprietary drug discovery platform.
31GF Score
Get the complete analysis for PLRX
Debt-to-Equity is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.
Quick Browse
Personalize
Premium Gurus 
Create New Portfolio
PLRX has been successfully added to your 
