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Sionna TherapeuticsSION +9.31%12 Debt-to-Equity is 0.03 as of Mar. 2026, which is at its 10-year median of 0.03. GuruFocus rates SION with a GF Score™ of 12/100. The stock has 3 warning signs investors should review. Among 965 Biotechnology companies, Sionna Therapeutics ranks better than 81.24% on this metric.
A high debt to equity ratio generally means that a company has been aggressive in financing its growth with debt. This can result in volatile earnings as a result of the additional interest expense.
The historical rank and industry rank for Sionna Therapeutics's Debt-to-Equity or its related term are showing as below:
SION'
s Debt-to-Equity Range Over the Past 10 Years
Min: -0.09 Med: 0.03 Max: 0.03
Current: 0.03
During the past 4 years, the highest Debt-to-Equity Ratio of Sionna Therapeutics was 0.03. The lowest was -0.09. And the median was 0.03.
SION's Debt-to-Equity is ranked better than 81.24% of 965
companies
in the Biotechnology industry
Industry Median: 0.16
vs SION: 0.03
Because a company can increase its ROE % by having more financial leverage, it is important to watch the leverage ratio when investing in high ROE % companies.
Sionna Therapeutics Debt-to-Equity Related Terms
Sionna Therapeutics Debt-to-Equity Historical Data
* Premium members only.
The historical data trend for Sionna Therapeutics's Debt-to-Equity can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
SION vs TYRA, RAPP, IOVA: Debt-to-Equity Comparison
For the Biotechnology subindustry, Sionna Therapeutics's Debt-to-Equity, along with its competitors' market caps and Debt-to-Equity data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Sionna Therapeutics Debt-to-Equity vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Sionna Therapeutics's Debt-to-Equity distribution charts can be found below:
* The bar in red indicates where Sionna Therapeutics's Debt-to-Equity falls into.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Sionna Therapeutics (SION) has a Debt-to-Equity of 0.03 as of Mar. 2026. Debt-to-Equity ratio represents the ratio of total debt to total company equity. View historical data on Sionna Therapeutics and its competitors. This is near median its historical median of 0.03. According to the industry distribution chart, Sionna Therapeutics ranks #181 out of 965 companies in the Biotechnology industry, placing it in the top 18.8%.
Is Sionna Therapeutics' Debt-to-Equity too high?
Sionna Therapeutics' current Debt-to-Equity of 0.03 is near median its 10-year median of 0.03. The Biotechnology industry median Debt-to-Equity is 0.16. Sionna Therapeutics' value of 0.03 is 81.3% below this industry median. Based on the distribution chart, Sionna Therapeutics ranks #181 out of 965 companies in the Biotechnology industry, which is in the top quartile — a strong position relative to peers. Overall, Sionna Therapeutics has a GF Score™ of 12/100, reflecting its overall financial health beyond just this single metric.
How does Sionna Therapeutics' Debt-to-Equity compare to TYRA and RAPP?
According to the Biotechnology industry distribution chart, Sionna Therapeutics ranks #181 out of 965 companies for Debt-to-Equity. This places Sionna Therapeutics in the top 19% of its industry — outperforming the majority of peers. The industry median Debt-to-Equity is 0.16. Sionna Therapeutics' value of 0.03 is 81.3% below this benchmark. While the company's 10-year median is 0.03 vs. the industry median of 0.16, Sionna Therapeutics has consistently been below the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Debt-to-Equity for a Biotechnology company?
The median Debt-to-Equity among Biotechnology companies is 0.16, based on 965 companies in the industry. Companies in the top quartile (top 25%) have a Debt-to-Equity significantly above this median, while those in the bottom quartile fall well below. However, Debt-to-Equity should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Sionna Therapeutics's current Debt-to-Equity of 0.03 is 81.3% below the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Debt-to-Equity mean?
A high Debt-to-Equity can signal that a stock is expensive relative to its fundamentals. Debt-to-Equity ratio represents the ratio of total debt to total company equity. View historical data on Sionna Therapeutics and its competitors. For the Biotechnology industry, the median Debt-to-Equity is 0.16 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Sionna Therapeutics's current Debt-to-Equity is 0.03, which is near median its own 10-year median of 0.03. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Sionna Therapeutics stock overvalued right now?
Sionna Therapeutics (SION) has a current Debt-to-Equity of 0.03. The current Debt-to-Equity is 0.03, which is near median its 10-year median of 0.03 and 81.3% below the Biotechnology industry median of 0.16. Sionna Therapeutics' overall GF Score™ is 12/100 with 3 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Debt-to-Equity calculated?
Debt-to-Equity is calculated from a company's financial statements. For Sionna Therapeutics (SION), the current Debt-to-Equity is 0.03 as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Sionna Therapeutics Inc is a clinical-stage biopharmaceutical company on a mission to revolutionize the current treatment paradigm for cystic fibrosis (CF) patients by developing novel medicines that normalize the function of the cystic fibrosis transmembrane conductance regulator (CFTR) protein to deliver clinically meaningful benefits to CF patients. CF is a progressive and life-threatening genetic disease caused by inherited mutations in the CFTR gene, which heads to insufficient CFTR function. The Company is managed as one operating segment focused on the research and development of cystic fibrosis therapies.
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