SION (Sionna Therapeutics) ROC (Joel Greenblatt) %: -1,322.71% (As of Mar. 2026)


SION Sionna Therapeutics Inc SION
12 GF Score
Price $43.99
! 3 Warning Signs
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What is Sionna Therapeutics ROC (Joel Greenblatt) %?

Sionna Therapeutics SION +5.64% 12 ROC (Joel Greenblatt) % is -1,322.71% as of Mar. 2026. GuruFocus rates SION with a GF Score™ of 12/100. The stock has 3 warning signs investors should review. Among 1,324 Biotechnology companies, Sionna Therapeutics ranks worse than 67.9% on this metric.

Joel Greenblatt defined Return on Capital differently in his book The Little Book That Still Beats the Market (Little Books. Big Profits). He defines ROC (Joel Greenblatt) % as EBIT divided by the total of Property, Plant and Equipment and net working capital. Sionna Therapeutics's annualized ROC (Joel Greenblatt) % for the quarter that ended in Mar. 2026 was -1,322.71%.

The historical rank and industry rank for Sionna Therapeutics's ROC (Joel Greenblatt) % or its related term are showing as below:

SION' s ROC (Joel Greenblatt) % Range Over the Past 10 Years
Min: -1607.3   Med: -809.35   Max: -640.54
Current: -1055.46

During the past 4 years, Sionna Therapeutics's highest ROC (Joel Greenblatt) % was -640.54%. The lowest was -1607.30%. And the median was -809.35%.

SION's ROC (Joel Greenblatt) % is ranked worse than
67.9% of 1324 companies
in the Biotechnology industry
Industry Median: -297.06 vs SION: -1055.46

Sionna Therapeutics's 5-Year average Growth Rate of ROC (Joel Greenblatt) % was 0.00% per year.


Sionna Therapeutics  (NAS:SION) ROC (Joel Greenblatt) % Explanation

The way Joel Greenblatt defines Return on Capital is a more accurate measure of how efficiently the company generates returns onthe capital actually invested in the business. EBIT is used instead of net income because the tax and interest payment may be affected by factors other than the core business operation. Intangible assets are not included in the calculation because they don't need to be replaced.

Joel Greenblatt uses his definition of Return on Capital and Earnings Yield (Joel Greenblatt) % to rank companies.


Sionna Therapeutics ROC (Joel Greenblatt) % Related Terms


Sionna Therapeutics ROC (Joel Greenblatt) % Historical Data

* Premium members only.

The historical data trend for Sionna Therapeutics's ROC (Joel Greenblatt) % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Sionna Therapeutics ROC (Joel Greenblatt) % Chart

Sionna Therapeutics Annual Data
Trend Dec22 Dec23 Dec24 Dec25
ROC (Joel Greenblatt) %
-1,607.30 -703.66 -640.54 -915.03

Sionna Therapeutics Quarterly Data
Dec22 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
ROC (Joel Greenblatt) % Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only -774.43 -891.80 -1,004.96 -1,023.27 -1,322.71

SION vs TYRA, RAPP, IOVA: ROC (Joel Greenblatt) % Comparison

For the Biotechnology subindustry, Sionna Therapeutics's ROC (Joel Greenblatt) %, along with its competitors' market caps and ROC (Joel Greenblatt) % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Sionna Therapeutics ROC (Joel Greenblatt) % vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Sionna Therapeutics's ROC (Joel Greenblatt) % distribution charts can be found below:

* The bar in red indicates where Sionna Therapeutics's ROC (Joel Greenblatt) % falls into.


SION
12GF Score
Sionna Therapeutics Inc SION
ROC (Joel Greenblatt) % is just one metric. See GF Score™, valuation, warning signs, and more.
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Sionna Therapeutics ROC (Joel Greenblatt) % Calculation

Joel Greenblatt defined Return on Capital differently in his book The Little Book That Still Beats the Market (Little Books. Big Profits) . He defines Return on Capital as follows:

ROC (Joel Greenblatt) %=EBIT/Average of (Net fixed Assets + Net Working Capital)

EBIT stands for Earnings Before Interest and Taxes.

Fixed Assets are also known as non-current assets. They include the Property, Plant and Equipment that the firm needs in its operation.

GuruFocus calculates net working capital as: (Accounts Receivable + Total Inventories + Other Current Assets) - (Accounts Payable & Accrued Expense + Deferred Revenue + Other Current Liabilities). We're trying to account for OPERATING assets and liabilities (part of daily business) when calculating working capital. Cash and marketable securities are considered NON-OPERATING assets and are not included in calculation. We will also back out all interest bearing debt, short term debt and the portion of long term debt that is due in the current period from the current liabilities. This debt will be considered when computing cost of capital and it would be inappropriate to count it twice.

Working Capital(Q: Dec. 2025 )
=(Accounts Receivable + Total Inventories + Other Current Assets) - (Accounts Payable & Accrued Expense + Defer. Rev. + Other Current Liabilities)
=(0 + 0 + 5.537) - (5.697 + 0 + 4.746)
=-4.906

Working Capital(Q: Mar. 2026 )
=(Accounts Receivable + Total Inventories + Other Current Assets) - (Accounts Payable & Accrued Expense + Defer. Rev. + Other Current Liabilities)
=(0 + 0 + 4.809) - (6.944 + 0 + 1.51)
=-3.645

When net working capital is negative, 0 is used.

So ROC (Joel Greenblatt) % of Sionna Therapeutics for the quarter that ended in Mar. 2026 can be restated as:

ROC (Joel Greenblatt) %(Q: Mar. 2026 )
=EBIT/Average of (Net fixed Assets + Net Working Capital)
=EBIT/Average of (Property, Plant and Equipment+Net Working Capital)
     Q: Dec. 2025  Q: Mar. 2026
=EBIT/( ( (Property, Plant and Equipment + Net Working Capital) + (Property, Plant and Equipment + Net Working Capital) )/ count )
=-118.396/( ( (9.151 + max(-4.906, 0)) + (8.751 + max(-3.645, 0)) )/ 2 )
=-118.396/( ( 9.151 + 8.751 )/ 2 )
=-118.396/8.951
=-1,322.71 %

Note: The EBIT data used here is four times the quarterly (Mar. 2026) EBIT data.

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

What does a ROC (Joel Greenblatt) % of -1,322.71% mean?
Sionna Therapeutics (SION) has a ROC (Joel Greenblatt) % of -1,322.71% as of Mar. 2026. Joel Greenblatt's return on capital is the ratio of EBIT to average fixed assets and net working capital. View historical data on Sionna Therapeutics and its competitors. According to the industry distribution chart, Sionna Therapeutics ranks #899 out of 1324 companies in the Biotechnology industry, placing it in the top 67.9%.
Is Sionna Therapeutics' ROC (Joel Greenblatt) % too high?
Sionna Therapeutics' current ROC (Joel Greenblatt) % is -1,322.71%. Based on the distribution chart, Sionna Therapeutics ranks #899 out of 1324 companies in the Biotechnology industry, which is below the industry midpoint. Overall, Sionna Therapeutics has a GF Score™ of 12/100, reflecting its overall financial health beyond just this single metric.
How does Sionna Therapeutics' ROC (Joel Greenblatt) % compare to TYRA and RAPP?
According to the Biotechnology industry distribution chart, Sionna Therapeutics ranks #899 out of 1324 companies for ROC (Joel Greenblatt) %. This places Sionna Therapeutics in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good ROC (Joel Greenblatt) % for a Biotechnology company?
A good ROC (Joel Greenblatt) % depends on the Biotechnology industry context. However, ROC (Joel Greenblatt) % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high ROC (Joel Greenblatt) % mean?
A high ROC (Joel Greenblatt) % can signal that a stock is expensive relative to its fundamentals. Joel Greenblatt's return on capital is the ratio of EBIT to average fixed assets and net working capital. View historical data on Sionna Therapeutics and its competitors. Sionna Therapeutics's current ROC (Joel Greenblatt) % is -1,322.71%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Sionna Therapeutics stock overvalued right now?
Sionna Therapeutics (SION) has a current ROC (Joel Greenblatt) % of -1,322.71%. The current ROC (Joel Greenblatt) % is -1,322.71%. Sionna Therapeutics' overall GF Score™ is 12/100 with 3 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is ROC (Joel Greenblatt) % calculated?
ROC (Joel Greenblatt) % is calculated from a company's financial statements. For Sionna Therapeutics (SION), the current ROC (Joel Greenblatt) % is -1,322.71% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Sionna Therapeutics Business Description

Address 21 Hickory Drive, Suite 500, Waltham, MA, USA, 02451
Sionna Therapeutics Inc is a clinical-stage biopharmaceutical company on a mission to revolutionize the current treatment paradigm for cystic fibrosis (CF) patients by developing novel medicines that normalize the function of the cystic fibrosis transmembrane conductance regulator (CFTR) protein to deliver clinically meaningful benefits to CF patients. CF is a progressive and life-threatening genetic disease caused by inherited mutations in the CFTR gene, which heads to insufficient CFTR function. The Company is managed as one operating segment focused on the research and development of cystic fibrosis therapies.
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ROC (Joel Greenblatt) % is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

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