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Twist BioscienceTWST +4.43%69 Debt-to-Equity is 0.21 as of Jun. 2026, which is 75% above its 10-year median of 0.12. GuruFocus rates TWST with a GF Score™ of 69/100 and a GF Value™ of $52.17 (Significantly Overvalued). The stock has 5 warning signs investors should review. Among 183 Medical Diagnostics & Research companies, Twist Bioscience ranks better than 55.19% on this metric.
A high debt to equity ratio generally means that a company has been aggressive in financing its growth with debt. This can result in volatile earnings as a result of the additional interest expense.
The historical rank and industry rank for Twist Bioscience's Debt-to-Equity or its related term are showing as below:
TWST'
s Debt-to-Equity Range Over the Past 10 Years
Min: -0.15 Med: 0.12 Max: 0.42
Current: 0.21
During the past 10 years, the highest Debt-to-Equity Ratio of Twist Bioscience was 0.42. The lowest was -0.15. And the median was 0.12.
TWST's Debt-to-Equity is ranked better than 55.19% of 183
companies
in the Medical Diagnostics & Research industry
Industry Median: 0.31
vs TWST: 0.21
Because a company can increase its ROE % by having more financial leverage, it is important to watch the leverage ratio when investing in high ROE % companies.
Twist Bioscience Debt-to-Equity Related Terms
Twist Bioscience Debt-to-Equity Historical Data
* Premium members only.
The historical data trend for Twist Bioscience's Debt-to-Equity can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
TWST vs BLLN, SHC, RDNT: Debt-to-Equity Comparison
For the Diagnostics & Research subindustry, Twist Bioscience's Debt-to-Equity, along with its competitors' market caps and Debt-to-Equity data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Twist Bioscience Debt-to-Equity vs Medical Diagnostics & Research Industry
For the Medical Diagnostics & Research industry and Healthcare sector, Twist Bioscience's Debt-to-Equity distribution charts can be found below:
* The bar in red indicates where Twist Bioscience's Debt-to-Equity falls into.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Twist Bioscience (TWST) has a Debt-to-Equity of 0.21 as of Jun. 2026. Debt-to-Equity ratio represents the ratio of total debt to total company equity. View historical data on Twist Bioscience and its competitors. This is 75% above median its historical median of 0.12. According to the industry distribution chart, Twist Bioscience ranks #82 out of 183 companies in the Medical Diagnostics & Research industry, placing it in the top 44.8%.
Is Twist Bioscience's Debt-to-Equity too high?
Twist Bioscience's current Debt-to-Equity of 0.21 is 75% above median its 10-year median of 0.12. The Medical Diagnostics & Research industry median Debt-to-Equity is 0.31. Twist Bioscience's value of 0.21 is 32.3% below this industry median. Based on the distribution chart, Twist Bioscience ranks #82 out of 183 companies in the Medical Diagnostics & Research industry, which is above the industry midpoint. Overall, Twist Bioscience has a GF Score™ of 69/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Twist Bioscience's Debt-to-Equity compare to BLLN and SHC?
According to the Medical Diagnostics & Research industry distribution chart, Twist Bioscience ranks #82 out of 183 companies for Debt-to-Equity. This puts Twist Bioscience in the upper half of its industry. The industry median Debt-to-Equity is 0.31. Twist Bioscience's value of 0.21 is 32.3% below this benchmark. While the company's 10-year median is 0.12 vs. the industry median of 0.31, Twist Bioscience has consistently been below the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Debt-to-Equity for a Medical Diagnostics & Research company?
The median Debt-to-Equity among Medical Diagnostics & Research companies is 0.31, based on 183 companies in the industry. Companies in the top quartile (top 25%) have a Debt-to-Equity significantly above this median, while those in the bottom quartile fall well below. However, Debt-to-Equity should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Twist Bioscience's current Debt-to-Equity of 0.21 is 32.3% below the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Debt-to-Equity mean?
A high Debt-to-Equity can signal that a stock is expensive relative to its fundamentals. Debt-to-Equity ratio represents the ratio of total debt to total company equity. View historical data on Twist Bioscience and its competitors. For the Medical Diagnostics & Research industry, the median Debt-to-Equity is 0.31 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Twist Bioscience's current Debt-to-Equity is 0.21, which is 75% above median its own 10-year median of 0.12. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Twist Bioscience stock overvalued right now?
Based on GuruFocus' analysis, Twist Bioscience (TWST) is currently considered Significantly Overvalued. The stock's GF Value™ is $52.17, compared to a current price of $113.91 — trading 118.3% above its estimated fair value. The current Debt-to-Equity is 0.21, which is 75% above median its 10-year median of 0.12 and 32.3% below the Medical Diagnostics & Research industry median of 0.31. Twist Bioscience's overall GF Score™ is 69/100 with 5 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Debt-to-Equity calculated?
Debt-to-Equity is calculated from a company's financial statements. For Twist Bioscience (TWST), the current Debt-to-Equity is 0.21 as of Jun. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is Twist Bioscience (TWST) Overvalued in 2026?
Based on GuruFocus' analysis, Twist Bioscience stock appears to be overvalued.
The current stock price of $113.91 is trading 118.3% above its estimated GF Value™ of $52.17.
GuruFocus considers Twist Bioscience to be Significantly Overvalued.
Key valuation signals for TWST:
Debt-to-Equity: 0.21 (75% above median its 10-year median of 0.12)
GF Value™: $52.17 vs. price of $113.91 (118.3% above fair value)
Industry Position: 32.3% below the Medical Diagnostics & Research median (#82 of 183)
No single metric tells the full story. See the TWST stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
Twist Bioscience Corp is a synthetic biology company that has developed a disruptive DNA synthesis platform to industrialize the engineering of biology. The company's proprietary semiconductor-based manufacturing process synthesizes DNA on silicon rather than traditional plastic plates, enabling the production of high-quality synthetic DNA faster, more affordably, and at scale. This platform overcomes conventional inefficiencies, supports cost-effective, high-throughput synthesis, and allows researchers to accelerate innovation. Geographically, the company operates across the Americas, EMEA, and APAC, deriving the majority of its revenue from the Americas.
69GF Score
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