Otsuka Holdings Co (TSE:4578) E10: 円341.78 (As of Mar. 2026)

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TSE:4578 Otsuka Holdings Co Ltd TSE:4578
90 GF Score
Price 円11,155.00
GF Value 円8,384.31
Valuation Significantly Overvalued
! 5 Warning Signs
View Full Analysis

What is Otsuka Holdings Co E10?

Otsuka Holdings Co TSE:4578 +2.20% 90 E10 is 円341.78 as of Mar. 2026. GuruFocus rates TSE:4578 with a GF Score™ of 90/100 and a GF Value™ of 円8,384.31 (Significantly Overvalued). The stock has 5 warning signs investors should review.

E10 is a concept invented by Prof. Robert Shiller, who uses E10 for his Shiller P/E calculation. E10 is the average of the inflation adjusted earnings of a company over the past 10 years.

Otsuka Holdings Co's adjusted earnings per share data for the three months ended in Mar. 2026 was 円186.310. Add all the adjusted EPS for the past 10 years together and divide 10 will get our e10, which is 円341.78 for the trailing ten years ended in Mar. 2026.

During the past 12 months, Otsuka Holdings Co's average E10 Growth Rate was 19.90% per year. During the past 3 years, the average E10 Growth Rate was 10.90% per year. During the past 5 years, the average E10 Growth Rate was 7.70% per year. Please click Growth Rate Calculation Example (GuruFocus) to see how GuruFocus calculates Wal-Mart Stores Inc (WMT)'s revenue growth rate. You can apply the same method to get the E10 growth rate using E10 data.

During the past 13 years, the highest 3-Year average E10 Growth Rate of Otsuka Holdings Co was 10.90% per year. The lowest was 2.10% per year. And the median was 4.50% per year.

As of today (2026-07-25), Otsuka Holdings Co's current stock price is 円11155.00. Otsuka Holdings Co's E10 for the quarter that ended in Mar. 2026 was 円341.78. Otsuka Holdings Co's Shiller PE Ratio of today is 32.64.

During the past 13 years, the highest Shiller PE Ratio of Otsuka Holdings Co was 37.65. The lowest was 15.89. And the median was 21.25.


Otsuka Holdings Co  (TSE:4578) E10 Explanation

If a company grows much fast than inflation, E10 may underestimate the company's earnings power. Shiller PE Ratio can seem to be too high even the actual P/E is low.

For the Shiller P/E, the earnings of the past 10 years are inflation-adjusted and averaged. The result is used for P/E calculation. Since it looks at the average over the last 10 years, the Shiller P/E is also called PE10.

The Shiller P/E was first used by professor Robert Shiller to measure the valuation of the overall market. The same calculation is applied here to individual companies.

Otsuka Holdings Co's Shiller P/E Ratio of today is calculated as

Shiller PE Ratio=Share Price/E10
=11155.00/341.78
=32.64

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

During the past 13 years, the highest Shiller P/E Ratio of Otsuka Holdings Co was 37.65. The lowest was 15.89. And the median was 21.25.


Be Aware

Shiller PE Ratio works better for cyclical companies. It gives you a better idea on the company's real earnings power.


Otsuka Holdings Co E10 Related Terms


Otsuka Holdings Co E10 Historical Data

* Premium members only.

The historical data trend for Otsuka Holdings Co's E10 can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Otsuka Holdings Co E10 Chart

Otsuka Holdings Co Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
E10
Get a 7-Day Free Trial Premium Member Only Premium Member Only 225.66 240.85 234.10 275.40 328.67

Otsuka Holdings Co Quarterly Data
Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
E10 Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only 285.14 295.99 313.19 328.67 341.78

TSE:4578 vs LLY, JNJ, ABBV: E10 Comparison

For the Drug Manufacturers - General subindustry, Otsuka Holdings Co's Shiller PE Ratio, along with its competitors' market caps and Shiller PE Ratio data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Otsuka Holdings Co Shiller PE Ratio vs Drug Manufacturers Industry

For the Drug Manufacturers industry and Healthcare sector, Otsuka Holdings Co's Shiller PE Ratio distribution charts can be found below:

* The bar in red indicates where Otsuka Holdings Co's Shiller PE Ratio falls into.


TSE:4578
90GF Score
Otsuka Holdings Co Ltd TSE:4578
E10 is just one metric. See GF Score™, valuation, warning signs, and more.
View Full Analysis

Otsuka Holdings Co E10 Calculation

E10 is a concept invented by Prof. Robert Shiller, who uses E10 for his Shiller P/E calculation. When we calculate the today's Shiller P/E ratio of a stock, we use today's price divided by E10.

What is E10? How do we calculate E10?

E10 is the average of the inflation adjusted earnings of a company over the past 10 years. Let's use an example to explain.

If we want to calculate the E10 of Wal-Mart (WMT) for Dec. 31, 2010, we need to have the inflation data and the earnings from 2001 through 2010.

We adjusted the earnings of 2001 earnings data with the total inflation from 2001 through 2010 to the equivalent earnings in 2010. If the total inflation from 2001 to 2010 is 40%, and Wal-Mart earned $1 a share in 2001, then the 2001's equivalent earnings in 2010 is $1.4 a share. If Wal-Mart earns $1 again in 2002, and the total inflation from 2002 through 2010 is 35%, then the equivalent 2002 earnings in 2010 is $1.35. So on and so forth, you get the equivalent earnings of past 10 years. Then you add them together and divided the sum by 10 to get E10.

Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.

For example, Otsuka Holdings Co's adjusted earnings per share data for the three months ended in Mar. 2026 was:

Adj_EPS= Earnings per Share (Diluted) /CPI of Mar. 2026 (Change)*Current CPI (Mar. 2026)
=186.31/112.7000*112.7000
=186.310

Current CPI (Mar. 2026) = 112.7000.

Otsuka Holdings Co Quarterly Data

per share eps CPI Adj_EPS
201606 51.220 98.100 58.843
201609 106.950 98.000 122.993
201612 -27.820 98.400 -31.863
201703 38.520 98.100 44.253
201706 39.260 98.500 44.920
201709 55.950 98.800 63.822
201712 72.750 99.400 82.484
201803 41.240 99.200 46.852
201806 75.960 99.200 86.297
201809 24.460 99.900 27.594
201812 8.090 99.700 9.145
201903 33.870 99.700 38.286
201906 88.190 99.800 99.589
201909 77.280 100.100 87.008
201912 28.820 100.500 32.319
202003 67.950 100.300 76.351
202006 89.010 99.900 100.415
202009 74.710 99.900 84.282
202012 37.560 99.300 42.629
202103 81.610 99.900 92.067
202106 85.290 99.500 96.605
202109 64.800 100.100 72.957
202112 -2.190 100.100 -2.466
202203 42.700 101.100 47.599
202206 85.690 101.800 94.865
202209 76.020 103.100 83.098
202212 42.140 104.100 45.621
202303 113.180 104.400 122.178
202306 75.850 105.200 81.258
202309 108.930 106.200 115.597
202312 -73.890 106.800 -77.972
202403 142.590 107.200 149.906
202406 56.030 108.200 58.360
202409 154.720 108.900 160.119
202412 280.430 110.700 285.496
202503 158.570 111.100 160.854
202506 167.550 111.700 169.050
202509 234.690 112.000 236.157
202512 124.250 113.000 123.920
202603 186.310 112.700 186.310

Add all the adjusted EPS together and divide 10 will get our e10.

Frequently Asked Questions Learn more about E10 →
What does a E10 of 円341.78 mean?
Otsuka Holdings Co (TSE:4578) has a E10 of 円341.78 as of Mar. 2026. E10 represents the company's inflation-adjusted earnings per share over a 10-year period. View historical data on Otsuka Holdings Co and its competitors.
Is Otsuka Holdings Co's E10 too high?
Otsuka Holdings Co's current E10 is 円341.78. Overall, Otsuka Holdings Co has a GF Score™ of 90/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Otsuka Holdings Co's E10 compare to LLY and JNJ?
Otsuka Holdings Co's E10 of 円341.78 can be compared against companies in the Drug Manufacturers industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good E10 for a Drug Manufacturers company?
A good E10 depends on the Drug Manufacturers industry context. However, E10 should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high E10 mean?
A high E10 can signal that a stock is expensive relative to its fundamentals. E10 represents the company's inflation-adjusted earnings per share over a 10-year period. View historical data on Otsuka Holdings Co and its competitors. Otsuka Holdings Co's current E10 is 円341.78. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Otsuka Holdings Co stock overvalued right now?
Based on GuruFocus' analysis, Otsuka Holdings Co (TSE:4578) is currently considered Significantly Overvalued. The stock's GF Value™ is 円8,384.31, compared to a current price of 円11,155.00 — trading 33% above its estimated fair value. The current E10 is 円341.78. Otsuka Holdings Co's overall GF Score™ is 90/100 with 5 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is E10 calculated?
E10 is calculated from a company's financial statements. For Otsuka Holdings Co (TSE:4578), the current E10 is 円341.78 as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is Otsuka Holdings Co (TSE:4578) Overvalued in 2026?

Based on GuruFocus' analysis, Otsuka Holdings Co stock appears to be overvalued. The current stock price of 円11,155.00 is trading 33% above its estimated GF Value™ of 円8,384.31. GuruFocus considers Otsuka Holdings Co to be Significantly Overvalued.

Key valuation signals for TSE:4578:

  • E10: 円341.78
  • GF Value™: 円8,384.31 vs. price of 円11,155.00 (33% above fair value)
  • GF Score™: 90/100 with 5 warning signs

No single metric tells the full story. See the TSE:4578 stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


Otsuka Holdings Co Business Description

Address 2-16-4 Konan, Shinagawa Grand Central Tower, Minato-ku, Tokyo, JPN, 108-8241
Otsuka Holdings Co Ltd is a Japan-based company that operates in pharmaceuticals, nutraceuticals, and consumer products. It operates through four reportable segments: Medical-related Business, Nutraceutical-related Business, Consumer-related Business, and Other Business. The Medical Business manufactures and sells therapeutic drugs and infusions, the Nutraceutical Business produces functional foods, beverages, and nutritional supplements, the Consumer Business offers mineral water, beverages, and foods, while the Other Business provides storage services and manufactures chemicals and analytical equipment. It generates the majority of its revenue from the medical-related business segment.
90GF Score

Get the complete analysis for TSE:4578

E10 is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

円11,155.00
Price
円8,384.31
GF Value