Carna Biosciences (TSE:4572) EV-to-EBIT: -4.36 (As of Aug. 22, 2026)

Author: Vera Yuan Vera Yuan
Vera Yuan
Vera Yuan
Director of Data and Quant Analytics at GuruFocus
Focused on building reliable datasets, financial models, and research tools for value-minded investors. Committed to turning complex data into practical guidance for value-investing and long-term wealth.
Reviewed by: Charlie Tian Charlie Tian
Charlie Tian
Charlie Tian
Founder & CEO of GuruFocus
Dr. Charlie Tian is the founder and CEO of GuruFocus.com, a leading global investment research platform established in 2004. With a Ph.D. in physics, Dr. Tian transitioned from science to finance, applying a data-driven, disciplined approach to value investing.

TSE:4572 Carna Biosciences Inc TSE:4572
28 GF Score
Price 円403.00
GF Value 円205.34
Valuation Significantly Overvalued
! 6 Warning Signs
View Full Analysis

What is Carna Biosciences EV-to-EBIT?

Carna Biosciences TSE:4572 -0.98% 28 EV-to-EBIT is -4.36 as of Aug. 22, 2026. GuruFocus rates TSE:4572 with a GF Score™ of 28/100 and a GF Value™ of 円205.34 (Significantly Overvalued). The stock has 6 warning signs investors should review. Among 373 Biotechnology companies, Carna Biosciences ranks worse than 268096.25% on this metric.

EV-to-EBIT is calculated as Enterprise Value divided by its EBIT. As of today, Carna Biosciences's Enterprise Value is 円9,410.3 Mil. Carna Biosciences's EBIT for the trailing twelve months (TTM) ended in Jun. 2026 was 円-2,160.3 Mil. Therefore, Carna Biosciences's EV-to-EBIT for today is -4.36.

The historical rank and industry rank for Carna Biosciences's EV-to-EBIT or its related term are showing as below:

TSE:4572' s EV-to-EBIT Range Over the Past 10 Years
Min: -88.84   Med: -7.41   Max: 42.23
Current: -4.35

During the past 13 years, the highest EV-to-EBIT of Carna Biosciences was 42.23. The lowest was -88.84. And the median was -7.41.

TSE:4572's EV-to-EBIT is ranked worse than
100% of 373 companies
in the Biotechnology industry
Industry Median: 15.29 vs TSE:4572: -4.35

Joel Greenblatt calls the inversion of this ratio Earnings Yield (Joel Greenblatt) %. Carna Biosciences's Enterprise Value for the quarter that ended in Jun. 2026 was 円7,903.7 Mil. Carna Biosciences's EBIT for the trailing twelve months (TTM) ended in Jun. 2026 was 円-2,160.3 Mil. Carna Biosciences's Earnings Yield (Joel Greenblatt) % for the quarter that ended in Jun. 2026 was -27.33%.


Carna Biosciences  (TSE:4572) EV-to-EBIT Explanation

This is a more accurate valuation of companies' operation because it considers the debt and cash on its balance sheet, and non-operating items such as interest payment, tax, and one-time items are not included in the Operating Income.

Joel Greenblatt calls the inversion of this ratio Earnings Yield (Joel Greenblatt) %.

Carna Biosciences's Earnings Yield (Joel Greenblatt) % for the quarter that ended in Jun. 2026 is calculated as:

Earnings Yield (Joel Greenblatt) % (Q: Jun. 2026 ) =EBIT / Enterprise Value (Q: Jun. 2026 )
=-2160.272/7903.715
=-27.33 %

Carna Biosciences's Enterprise Value for the quarter that ended in Jun. 2026 was 円7,903.7 Mil.
Carna Biosciences's EBIT for the trailing twelve months (TTM) ended in Jun. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was 円-2,160.3 Mil.

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.


Carna Biosciences EV-to-EBIT Related Terms


Carna Biosciences EV-to-EBIT Historical Data

* Premium members only.

The historical data trend for Carna Biosciences's EV-to-EBIT can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Carna Biosciences EV-to-EBIT Chart

Carna Biosciences Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
EV-to-EBIT
Get a 7-Day Free Trial Premium Member Only Premium Member Only -21.54 -3.27 -5.54 -1.70 -3.25

Carna Biosciences Quarterly Data
Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26 Jun26
EV-to-EBIT Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -5.30 -2.30 -3.25 -3.72 -4.93

TSE:4572 vs VRTX, REGN, RVMD: EV-to-EBIT Comparison

For the Biotechnology subindustry, Carna Biosciences's EV-to-EBIT, along with its competitors' market caps and EV-to-EBIT data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Carna Biosciences EV-to-EBIT vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Carna Biosciences's EV-to-EBIT distribution charts can be found below:

* The bar in red indicates where Carna Biosciences's EV-to-EBIT falls into.


TSE:4572
28GF Score
Carna Biosciences Inc TSE:4572
EV-to-EBIT is just one metric. See GF Score™, valuation, warning signs, and more.
View Full Analysis

Carna Biosciences EV-to-EBIT Calculation

Carna Biosciences's EV-to-EBIT for today is calculated as:

EV-to-EBIT=Enterprise Value (Today)/EBIT (TTM)
=9410.300/-2160.272
=-4.36

Carna Biosciences's current Enterprise Value is 円9,410.3 Mil.
Carna Biosciences's EBIT for the trailing twelve months (TTM) ended in Jun. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was 円-2,160.3 Mil.

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Frequently Asked Questions Learn more about EV-to-EBIT →
What does a EV-to-EBIT of -4.36 mean?
Carna Biosciences (TSE:4572) has a EV-to-EBIT of -4.36 as of Aug. 22, 2026. EV to EBIT ratio is the inverse of Joel Greenblatt's earnings yield definition. View historical data on Carna Biosciences and its competitors. According to the industry distribution chart, Carna Biosciences ranks #999999 out of 373 companies in the Biotechnology industry.
Is Carna Biosciences' EV-to-EBIT too high?
Carna Biosciences' current EV-to-EBIT is -4.36. Based on the distribution chart, Carna Biosciences ranks #999999 out of 373 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, Carna Biosciences has a GF Score™ of 28/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Carna Biosciences' EV-to-EBIT compare to VRTX and REGN?
According to the Biotechnology industry distribution chart, Carna Biosciences ranks #999999 out of 373 companies for EV-to-EBIT. This places Carna Biosciences in the lower half of its industry. The industry median EV-to-EBIT is 15.29. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good EV-to-EBIT for a Biotechnology company?
The median EV-to-EBIT among Biotechnology companies is 15.29, based on 373 companies in the industry. Companies in the top quartile (top 25%) have a EV-to-EBIT significantly above this median, while those in the bottom quartile fall well below. However, EV-to-EBIT should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high EV-to-EBIT mean?
A high EV-to-EBIT can signal that a stock is expensive relative to its fundamentals. EV to EBIT ratio is the inverse of Joel Greenblatt's earnings yield definition. View historical data on Carna Biosciences and its competitors. For the Biotechnology industry, the median EV-to-EBIT is 15.29 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Carna Biosciences's current EV-to-EBIT is -4.36. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Carna Biosciences stock overvalued right now?
Based on GuruFocus' analysis, Carna Biosciences (TSE:4572) is currently considered Significantly Overvalued. The stock's GF Value™ is 円205.34, compared to a current price of 円403.00 — trading 96.3% above its estimated fair value. The current EV-to-EBIT is -4.36. Carna Biosciences' overall GF Score™ is 28/100 with 6 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is EV-to-EBIT calculated?
EV-to-EBIT is calculated from a company's financial statements. For Carna Biosciences (TSE:4572), the current EV-to-EBIT is -4.36 as of Aug. 22, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is Carna Biosciences (TSE:4572) Overvalued in 2026?

Based on GuruFocus' analysis, Carna Biosciences stock appears to be overvalued. The current stock price of 円403.00 is trading 96.3% above its estimated GF Value™ of 円205.34. GuruFocus considers Carna Biosciences to be Significantly Overvalued.

Key valuation signals for TSE:4572:

  • EV-to-EBIT: -4.36
  • GF Value™: 円205.34 vs. price of 円403.00 (96.3% above fair value)
  • GF Score™: 28/100 with 6 warning signs

No single metric tells the full story. See the TSE:4572 stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


Carna Biosciences Business Description

Address BMA 3F 1-5-5 Minatojima-Minamimachi, Kobe, JPN, 650-0047
Carna Biosciences Inc is a Japanese company engaged in drug discovery support business and drug discovery and development business. The company identifies and develops medicines for the treatment of cancer and inflammatory diseases using own kinase drug discovery platform, QuickScout.
28GF Score

Get the complete analysis for TSE:4572

EV-to-EBIT is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

円403.00
Price
円205.34
GF Value