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Carna BiosciencesTSE:4572 -1.61%43 3-Year ROIIC % is 1,677.08 as of Dec. 2025, which is 1196% above its 10-year median of 129.43. GuruFocus rates TSE:4572 with a GF Score™ of 43/100 and a GF Value™ of 円186.76 (Significantly Overvalued). The stock has 5 warning signs investors should review. Among 1,322 Biotechnology companies, Carna Biosciences ranks better than 95.69% on this metric.
3-Year Return on Invested Incremental Capital (3-Year ROIIC %) measures the change in earnings as a percentage of change in investment over 3-year.
Carna Biosciences's 3-Year ROIIC % for the quarter that ended in Dec. 2025 was 1,677.08%. High ROIIC is generally an indication that your business is capital efficient or has a higher operating leverage.
The industry rank for Carna Biosciences's 3-Year ROIIC % or its related term are showing as below:
TSE:4572's 3-Year ROIIC % is ranked better than 95.69% of 1322
companies
in the Biotechnology industry
Industry Median: -4.9
vs TSE:4572: 1677.08
Return on Incremental Invested Capital (ROIIC) is an extension of Return on Investment Capital (ROIC). ROIC % tells investors how efficiently that profitability is earned per dollar of company capital. ROIIC narrows the focus even further and shows how profitable each additional unit of capital investment could be. ROIIC % is a more powerful metric than ROIC because it measures how much money the company can generate going forward on future capital investments.
High ROIIC is generally an indication that your business is capital efficient or has a higher operating leverage.
Be Aware
It's important to keep in mind that when tracking ROIIC, the metric is better suited to forecasting the trend of future returns rather than measuring current return on investment.
Carna Biosciences 3-Year ROIIC % Related Terms
Carna Biosciences 3-Year ROIIC % Historical Data
* Premium members only.
The historical data trend for Carna Biosciences's 3-Year ROIIC % can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
TSE:4572 vs VRTX, REGN, ALNY: 3-Year ROIIC % Comparison
For the Biotechnology subindustry, Carna Biosciences's 3-Year ROIIC %, along with its competitors' market caps and 3-Year ROIIC % data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Carna Biosciences 3-Year ROIIC % vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Carna Biosciences's 3-Year ROIIC % distribution charts can be found below:
* The bar in red indicates where Carna Biosciences's 3-Year ROIIC % falls into.
Carna Biosciences's 3-Year ROIIC % for the quarter that ended in Dec. 2025 is calculated as:
3-Year ROIIC %
=
3-Year Incremental Net Operating Profit After Taxes (NOPAT)**
/
3-Year Incremental Invested Capital**
=
( -2074.972 (Dec. 2025) - -1269.889 (Dec. 2022) )
/
( 571.638 (Dec. 2025) - 619.643 (Dec. 2022) )
=
-805.083
/
-48.005000000001
=
1,677.08%***
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
** Annual data of NOPAT and Invested Capital was used to calculate 3-Year ROIIC %.
*** Please be aware that the ROIIC (Return on Invested Capital) calculations are based on company-level data using the primary share class. The calculated data provided is for demonstration purposes and may slightly differ from the results displayed in the title due to potential variations caused by currency exchange rate differences throughout the year.
Carna Biosciences (TSE:4572) has a 3-Year ROIIC % of 1,677.08 as of Dec. 2025. 3-Year ROIIC % measures the change in earnings as a percentage of change in investment over 3-year. View historical data on Carna Biosciences and its competitors. This is 1196% above median its historical median of 129.43. According to the industry distribution chart, Carna Biosciences ranks #57 out of 1322 companies in the Biotechnology industry, placing it in the top 4.3%.
Is Carna Biosciences' 3-Year ROIIC % too high?
Carna Biosciences' current 3-Year ROIIC % of 1,677.08 is 1196% above median its 10-year median of 129.43. Based on the distribution chart, Carna Biosciences ranks #57 out of 1322 companies in the Biotechnology industry, which is in the top quartile — a strong position relative to peers. Overall, Carna Biosciences has a GF Score™ of 43/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Carna Biosciences' 3-Year ROIIC % compare to VRTX and REGN?
According to the Biotechnology industry distribution chart, Carna Biosciences ranks #57 out of 1322 companies for 3-Year ROIIC %. This places Carna Biosciences in the top 4% of its industry — outperforming the majority of peers. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good 3-Year ROIIC % for a Biotechnology company?
A good 3-Year ROIIC % depends on the Biotechnology industry context. However, 3-Year ROIIC % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high 3-Year ROIIC % mean?
A high 3-Year ROIIC % can signal that a stock is expensive relative to its fundamentals. 3-Year ROIIC % measures the change in earnings as a percentage of change in investment over 3-year. View historical data on Carna Biosciences and its competitors. Carna Biosciences's current 3-Year ROIIC % is 1,677.08, which is 1196% above median its own 10-year median of 129.43. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Carna Biosciences stock overvalued right now?
Based on GuruFocus' analysis, Carna Biosciences (TSE:4572) is currently considered Significantly Overvalued. The stock's GF Value™ is 円186.76, compared to a current price of 円306.00 — trading 63.8% above its estimated fair value. The current 3-Year ROIIC % is 1,677.08, which is 1196% above median its 10-year median of 129.43. Carna Biosciences' overall GF Score™ is 43/100 with 5 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is 3-Year ROIIC % calculated?
3-Year ROIIC % is calculated from a company's financial statements. For Carna Biosciences (TSE:4572), the current 3-Year ROIIC % is 1,677.08 as of Dec. 2025. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is Carna Biosciences (TSE:4572) Overvalued in 2026?
Based on GuruFocus' analysis, Carna Biosciences stock appears to be overvalued.
The current stock price of 円306.00 is trading 63.8% above its estimated GF Value™ of 円186.76.
GuruFocus considers Carna Biosciences to be Significantly Overvalued.
Key valuation signals for TSE:4572:
3-Year ROIIC %: 1,677.08 (1196% above median its 10-year median of 129.43)
GF Value™: 円186.76 vs. price of 円306.00 (63.8% above fair value)
No single metric tells the full story. See the TSE:4572 stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
Carna Biosciences Inc is a Japanese company engaged in drug discovery support business and drug discovery and development business. The company identifies and develops medicines for the treatment of cancer and inflammatory diseases using own kinase drug discovery platform, QuickScout.
43GF Score
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