EV-to-EBITDA is calculated as enterprise value divided by its EBITDA. As of today, Spero Therapeutics's enterprise value is $69.10 Mil.
Spero Therapeutics's EBITDA for the trailing twelve months (TTM) ended in Mar. 2026 was $14.18 Mil. Therefore, Spero Therapeutics's EV-to-EBITDA for today is 4.87.
The historical rank and industry rank for Spero Therapeutics's EV-to-EBITDA or its related term are showing as below:
SPRO'
s EV-to-EBITDA Range Over the Past 10 Years
Min: -9.82 Med: -1.41 Max: 19.49
Current: 4.87
During the past 11 years, the highest EV-to-EBITDA of Spero Therapeutics was 19.49. The lowest was -9.82. And the median was -1.41.
SPRO's EV-to-EBITDA is ranked better than 67.6% of 392
companies
in the Biotechnology industry
Industry Median: 12.965
vs SPRO: 4.87
EV-to-EBITDA is a valuation multiple used in finance and investment to measure the value of a company. This important multiple is often used in conjunction with, or as an alternative to, the PE Ratio to determine the fair market value of a company.
EV-to-EBITDA is a valuation multiple used in finance and investment to measure the value of a company. This important multiple is often used in conjunction with, or as an alternative to, the PE Ratio (TTM) to determine the fair market value of a company.
Spero Therapeutics's PE Ratio (TTM) for today is calculated as:
Spero Therapeutics's share price for today is $2.12.
Spero Therapeutics's Earnings per Share (Diluted) for the trailing twelve months (TTM) ended in Mar. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was $0.240.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Study has found that the companies with the lowest EV-to-EBITDA outperforms companies measured as cheap by other ratios such as PE Ratio (TTM).
The historical data trend for Spero Therapeutics's EV-to-EBITDA can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
For the Biotechnology subindustry, Spero Therapeutics's EV-to-EBITDA, along with its competitors' market caps and EV-to-EBITDA data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Spero Therapeutics EV-to-EBITDA vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Spero Therapeutics's EV-to-EBITDA distribution charts can be found below:
* The bar in red indicates where Spero Therapeutics's EV-to-EBITDA falls into.
Spero Therapeutics's current Enterprise Value is $69.10 Mil.
Spero Therapeutics's EBITDA for the trailing twelve months (TTM) ended in Mar. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was $14.18 Mil.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Spero Therapeutics (SPRO) has a EV-to-EBITDA of 4.87 as of Jul. 09, 2026. EV to EBITDA ratio is the company's enterprise value divided by earnings before interest, taxes, depreciation and amortization. View historical data on Spero Therapeutics. According to the industry distribution chart, Spero Therapeutics ranks #127 out of 392 companies in the Biotechnology industry, placing it in the top 32.4%.
Is Spero Therapeutics' EV-to-EBITDA too high?
Spero Therapeutics' current EV-to-EBITDA is 4.87. The Biotechnology industry median EV-to-EBITDA is 12.97. Spero Therapeutics' value of 4.87 is 62.4% below this industry median. Based on the distribution chart, Spero Therapeutics ranks #127 out of 392 companies in the Biotechnology industry, which is above the industry midpoint. Overall, Spero Therapeutics has a GF Score™ of 55/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Spero Therapeutics' EV-to-EBITDA compare to VXRT and ADCT?
According to the Biotechnology industry distribution chart, Spero Therapeutics ranks #127 out of 392 companies for EV-to-EBITDA. This puts Spero Therapeutics in the upper half of its industry. The industry median EV-to-EBITDA is 12.97. Spero Therapeutics' value of 4.87 is 62.4% below this benchmark. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good EV-to-EBITDA for a Biotechnology company?
The median EV-to-EBITDA among Biotechnology companies is 12.97, based on 392 companies in the industry. Companies in the top quartile (top 25%) have a EV-to-EBITDA significantly above this median, while those in the bottom quartile fall well below. However, EV-to-EBITDA should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Spero Therapeutics's current EV-to-EBITDA of 4.87 is 62.4% below the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high EV-to-EBITDA mean?
A high EV-to-EBITDA can signal that a stock is expensive relative to its fundamentals. EV to EBITDA ratio is the company's enterprise value divided by earnings before interest, taxes, depreciation and amortization. View historical data on Spero Therapeutics. For the Biotechnology industry, the median EV-to-EBITDA is 12.97 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Spero Therapeutics's current EV-to-EBITDA is 4.87. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Spero Therapeutics stock overvalued right now?
Based on GuruFocus' analysis, Spero Therapeutics (SPRO) is currently considered Significantly Overvalued. The stock's GF Value™ is $1.05, compared to a current price of $2.12 — trading 101.9% above its estimated fair value. The current EV-to-EBITDA is 4.87 and 62.4% below the Biotechnology industry median of 12.97. Spero Therapeutics' overall GF Score™ is 55/100 with 4 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is EV-to-EBITDA calculated?
EV-to-EBITDA is calculated from a company's financial statements. For Spero Therapeutics (SPRO), the current EV-to-EBITDA is 4.87 as of Jul. 09, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is Spero Therapeutics (SPRO) Overvalued in 2026?
Based on GuruFocus' analysis, Spero Therapeutics stock appears to be overvalued.
The current stock price of $2.12 is trading 101.9% above its estimated GF Value™ of $1.05.
GuruFocus considers Spero Therapeutics to be Significantly Overvalued.
Key valuation signals for SPRO:
EV-to-EBITDA: 4.87
GF Value™: $1.05 vs. price of $2.12 (101.9% above fair value)
Industry Position: 62.4% below the Biotechnology median (#127 of 392)
No single metric tells the full story. See the SPRO stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
Spero Therapeutics Inc is a clinical-stage biopharmaceutical firm. It focuses on identifying, developing, and commercializing novel treatments for MDR (Multi-drug-resistant) bacterial infections and rare diseases. The company's product candidate, tebipenem pivoxil hydrobromide or tebipenem HBr, is designed to be an oral carbapenem-class antibiotic for use in adults to treat MDR Gram-negative infections. It is also developing SPR720, a novel oral antibiotic designed for the treatment of a rare, orphan disease caused by pulmonary non-tuberculous mycobacterial infections, or NTM disease. It is also focused on SPR206, a next-generation polymyxin investigational product candidate being developed as an IV-administered medicine to treat MDR Gram-negative infections in the hospital.
55GF Score
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