Spero TherapeuticsSPRO +0.66%55 Net Debt Paydown Yield % is 1.05% as of Jun. 29, 2026, which is 28% above its 10-year median of 0.82. GuruFocus rates SPRO with a GF Score™ of 55/100 and a GF Value™ of $1.06 (Significantly Overvalued). The stock has 4 warning signs investors should review. Among 1,163 Biotechnology companies, Spero Therapeutics ranks better than 74.2% on this metric.
Net Debt Paydown Yield % is a metric that evaluates the total amount of debt a company has paid in relation to its market capitalization. It is a measure of a company's willingness and ability to reduce its debt.
As of today, Spero Therapeutics's Net Debt Paydown Yield % was 1.05%.
Spero Therapeutics (NAS:SPRO) Net Debt Paydown Yield % Explanation
Net Debt Paydown Yield % is the change in average of four quarters of company's total debt over a company's market cap. Assuming the total value of a company remains that same, shareholder value is increased as debt is reduced. In other words, it is a measure of the willingness and ability of a firm's management to pay down debt. Companies that have high debt paydown yields indicate that they are more aggressive with paying down debt.
In the calculation of Net Debt Paydown Yield %, we use the reductions of TTM average total debt one-year-ago and TTM average total debt at present, divided by its Market Cap.
Spero Therapeutics Net Debt Paydown Yield % Related Terms
Spero Therapeutics Net Debt Paydown Yield % Historical Data
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The historical data trend for Spero Therapeutics's Net Debt Paydown Yield % can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
SPRO vs VXRT, ADCT, GNLX: Net Debt Paydown Yield % Comparison
For the Biotechnology subindustry, Spero Therapeutics's Net Debt Paydown Yield %, along with its competitors' market caps and Net Debt Paydown Yield % data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Spero Therapeutics Net Debt Paydown Yield % vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Spero Therapeutics's Net Debt Paydown Yield % distribution charts can be found below:
* The bar in red indicates where Spero Therapeutics's Net Debt Paydown Yield % falls into.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
* All the data are calculated by TTM values. Note that if a companies is traded in several exchanges, then we calculate the company level data for Net Debt Paydown Yield % using the primary share class stock data. The calculation result in definition page is for demonstration purpose only, and it's showing the share class level data. Therefore, the numbers in the calculation may differ from elsewhere if the stock is not a primary share.
What does a Net Debt Paydown Yield % of 1.05% mean?
Spero Therapeutics (SPRO) has a Net Debt Paydown Yield % of 1.05% as of Jun. 29, 2026. Net Debt Paydown Yield is a metric that evaluates the total amount of debt a company has paid in relation to its market capitalization. This metric provides insight into a company's willingness and ability to reduce its debt using free cash flow. View historical data on Spero Therapeutics and its competitors. This is 28% above median its historical median of 0.82. According to the industry distribution chart, Spero Therapeutics ranks #300 out of 1163 companies in the Biotechnology industry, placing it in the top 25.8%.
Is Spero Therapeutics' Net Debt Paydown Yield % too high?
Spero Therapeutics' current Net Debt Paydown Yield % of 1.05% is 28% above median its 10-year median of 0.82. The Biotechnology industry median Net Debt Paydown Yield % is 0.04. Spero Therapeutics' value of 1.05% is 2525% above this industry median. Based on the distribution chart, Spero Therapeutics ranks #300 out of 1163 companies in the Biotechnology industry, which is above the industry midpoint. Overall, Spero Therapeutics has a GF Score™ of 55/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Spero Therapeutics' Net Debt Paydown Yield % compare to VXRT and ADCT?
According to the Biotechnology industry distribution chart, Spero Therapeutics ranks #300 out of 1163 companies for Net Debt Paydown Yield %. This puts Spero Therapeutics in the upper half of its industry. The industry median Net Debt Paydown Yield % is 0.04. Spero Therapeutics' value of 1.05% is 2525% above this benchmark. While the company's 10-year median is 0.82 vs. the industry median of 0.04, Spero Therapeutics has consistently been above the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Net Debt Paydown Yield % for a Biotechnology company?
The median Net Debt Paydown Yield % among Biotechnology companies is 0.04, based on 1,163 companies in the industry. Companies in the top quartile (top 25%) have a Net Debt Paydown Yield % significantly above this median, while those in the bottom quartile fall well below. However, Net Debt Paydown Yield % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Spero Therapeutics's current Net Debt Paydown Yield % of 1.05% is 2525% above the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Net Debt Paydown Yield % mean?
A high Net Debt Paydown Yield % can signal that a stock is expensive relative to its fundamentals. Net Debt Paydown Yield is a metric that evaluates the total amount of debt a company has paid in relation to its market capitalization. This metric provides insight into a company's willingness and ability to reduce its debt using free cash flow. View historical data on Spero Therapeutics and its competitors. For the Biotechnology industry, the median Net Debt Paydown Yield % is 0.04 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Spero Therapeutics's current Net Debt Paydown Yield % is 1.05%, which is 28% above median its own 10-year median of 0.82. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Spero Therapeutics stock overvalued right now?
Based on GuruFocus' analysis, Spero Therapeutics (SPRO) is currently considered Significantly Overvalued. The stock's GF Value™ is $1.06, compared to a current price of $2.28 — trading 114.6% above its estimated fair value. The current Net Debt Paydown Yield % is 1.05%, which is 28% above median its 10-year median of 0.82 and 2525% above the Biotechnology industry median of 0.04. Spero Therapeutics' overall GF Score™ is 55/100 with 4 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Net Debt Paydown Yield % calculated?
Net Debt Paydown Yield % is calculated from a company's financial statements. For Spero Therapeutics (SPRO), the current Net Debt Paydown Yield % is 1.05% as of Jun. 29, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is Spero Therapeutics (SPRO) Overvalued in 2026?
Based on GuruFocus' analysis, Spero Therapeutics stock appears to be overvalued.
The current stock price of $2.28 is trading 114.6% above its estimated GF Value™ of $1.06.
GuruFocus considers Spero Therapeutics to be Significantly Overvalued.
Key valuation signals for SPRO:
Net Debt Paydown Yield %: 1.05% (28% above median its 10-year median of 0.82)
GF Value™: $1.06 vs. price of $2.28 (114.6% above fair value)
Industry Position: 2525% above the Biotechnology median (#300 of 1163)
No single metric tells the full story. See the SPRO stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
Spero Therapeutics Inc is a clinical-stage biopharmaceutical firm. It focuses on identifying, developing, and commercializing novel treatments for MDR (Multi-drug-resistant) bacterial infections and rare diseases. The company's product candidate, tebipenem pivoxil hydrobromide or tebipenem HBr, is designed to be an oral carbapenem-class antibiotic for use in adults to treat MDR Gram-negative infections. It is also developing SPR720, a novel oral antibiotic designed for the treatment of a rare, orphan disease caused by pulmonary non-tuberculous mycobacterial infections, or NTM disease. It is also focused on SPR206, a next-generation polymyxin investigational product candidate being developed as an IV-administered medicine to treat MDR Gram-negative infections in the hospital.
55GF Score
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