Oncolys BioPharma (TSE:4588) EV-to-EBITDA: -157.52 (As of Sep. 08, 2026)

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TSE:4588 Oncolys BioPharma Inc TSE:4588
39 GF Score
Price 円4,950.00
GF Value 円350.85
Valuation Significantly Overvalued
! 8 Warning Signs
View Full Analysis

What is Oncolys BioPharma EV-to-EBITDA?

Oncolys BioPharma TSE:4588 +7.73% 39 EV-to-EBITDA is -157.52 as of Sep. 08, 2026. GuruFocus rates TSE:4588 with a GF Score™ of 39/100 and a GF Value™ of 円350.85 (Significantly Overvalued). The stock has 8 warning signs investors should review. Among 399 Biotechnology companies, Oncolys BioPharma ranks worse than 250626.32% on this metric.

EV-to-EBITDA is calculated as enterprise value divided by its EBITDA. As of today, Oncolys BioPharma's enterprise value is 円143,344.24 Mil. Oncolys BioPharma's EBITDA for the trailing twelve months (TTM) ended in Jun. 2026 was 円-909.99 Mil. Therefore, Oncolys BioPharma's EV-to-EBITDA for today is -157.52.

The historical rank and industry rank for Oncolys BioPharma's EV-to-EBITDA or its related term are showing as below:

TSE:4588' s EV-to-EBITDA Range Over the Past 10 Years
Min: -157.53   Med: -7.57   Max: -3.26
Current: -157.53

During the past 13 years, the highest EV-to-EBITDA of Oncolys BioPharma was -3.26. The lowest was -157.53. And the median was -7.57.

TSE:4588's EV-to-EBITDA is ranked worse than
100% of 399 companies
in the Biotechnology industry
Industry Median: 13.7 vs TSE:4588: -157.53

EV-to-EBITDA is a valuation multiple used in finance and investment to measure the value of a company. This important multiple is often used in conjunction with, or as an alternative to, the PE Ratio to determine the fair market value of a company.

As of today (2026-09-08), Oncolys BioPharma's stock price is 円4950.00. Oncolys BioPharma's Earnings per Share (Diluted) for the trailing twelve months (TTM) ended in Jun. 2026 was 円-34.350. Therefore, Oncolys BioPharma's PE Ratio (TTM) for today is At Loss.

The "classic" EV-to-EBITDA is much better in capturing debt and net cash than the PE Ratio (TTM).


Oncolys BioPharma  (TSE:4588) EV-to-EBITDA Explanation

EV-to-EBITDA is a valuation multiple used in finance and investment to measure the value of a company. This important multiple is often used in conjunction with, or as an alternative to, the PE Ratio (TTM) to determine the fair market value of a company.

Oncolys BioPharma's PE Ratio (TTM) for today is calculated as:

PE Ratio (TTM)=Share Price (Today)/Earnings per Share (Diluted) (TTM)
=4950.00/-34.350
=At Loss

Oncolys BioPharma's share price for today is 円4950.00.
Oncolys BioPharma's Earnings per Share (Diluted) for the trailing twelve months (TTM) ended in Jun. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was 円-34.350.

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Study has found that the companies with the lowest EV-to-EBITDA outperforms companies measured as cheap by other ratios such as PE Ratio (TTM).

Please read Which price ratio outperforms the enterprise multiple?


Oncolys BioPharma EV-to-EBITDA Related Terms


Oncolys BioPharma EV-to-EBITDA Historical Data

* Premium members only.

The historical data trend for Oncolys BioPharma's EV-to-EBITDA can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Oncolys BioPharma EV-to-EBITDA Chart

Oncolys BioPharma Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
EV-to-EBITDA
Get a 7-Day Free Trial Premium Member Only Premium Member Only -3.87 -6.85 -5.14 -6.44 -18.14

Oncolys BioPharma Quarterly Data
Mar21 Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Dec24 Mar25 Jun25 Dec25 Mar26 Jun26
EV-to-EBITDA Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -11.68 -11.29 -18.14 -66.33 -205.27

TSE:4588 vs VRTX, REGN, MRNA: EV-to-EBITDA Comparison

For the Biotechnology subindustry, Oncolys BioPharma's EV-to-EBITDA, along with its competitors' market caps and EV-to-EBITDA data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Oncolys BioPharma EV-to-EBITDA vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Oncolys BioPharma's EV-to-EBITDA distribution charts can be found below:

* The bar in red indicates where Oncolys BioPharma's EV-to-EBITDA falls into.


TSE:4588
39GF Score
Oncolys BioPharma Inc TSE:4588
EV-to-EBITDA is just one metric. See GF Score™, valuation, warning signs, and more.
View Full Analysis

Oncolys BioPharma EV-to-EBITDA Calculation

Oncolys BioPharma's EV-to-EBITDA for today is calculated as:

EV-to-EBITDA=Enterprise Value (Today)/EBITDA (TTM)
=143344.238/-909.986
=-157.52

Oncolys BioPharma's current Enterprise Value is 円143,344.24 Mil.
Oncolys BioPharma's EBITDA for the trailing twelve months (TTM) ended in Jun. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was 円-909.99 Mil.

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Frequently Asked Questions Learn more about EV-to-EBITDA →
What does a EV-to-EBITDA of -157.52 mean?
Oncolys BioPharma (TSE:4588) has a EV-to-EBITDA of -157.52 as of Sep. 08, 2026. EV to EBITDA ratio is the company's enterprise value divided by earnings before interest, taxes, depreciation and amortization. View historical data on Oncolys BioPharma. According to the industry distribution chart, Oncolys BioPharma ranks #999999 out of 399 companies in the Biotechnology industry.
Is Oncolys BioPharma's EV-to-EBITDA too high?
Oncolys BioPharma's current EV-to-EBITDA is -157.52. Based on the distribution chart, Oncolys BioPharma ranks #999999 out of 399 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, Oncolys BioPharma has a GF Score™ of 39/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Oncolys BioPharma's EV-to-EBITDA compare to VRTX and REGN?
According to the Biotechnology industry distribution chart, Oncolys BioPharma ranks #999999 out of 399 companies for EV-to-EBITDA. This places Oncolys BioPharma in the lower half of its industry. The industry median EV-to-EBITDA is 13.70. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good EV-to-EBITDA for a Biotechnology company?
The median EV-to-EBITDA among Biotechnology companies is 13.70, based on 399 companies in the industry. Companies in the top quartile (top 25%) have a EV-to-EBITDA significantly above this median, while those in the bottom quartile fall well below. However, EV-to-EBITDA should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high EV-to-EBITDA mean?
A high EV-to-EBITDA can signal that a stock is expensive relative to its fundamentals. EV to EBITDA ratio is the company's enterprise value divided by earnings before interest, taxes, depreciation and amortization. View historical data on Oncolys BioPharma. For the Biotechnology industry, the median EV-to-EBITDA is 13.70 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Oncolys BioPharma's current EV-to-EBITDA is -157.52. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Oncolys BioPharma stock overvalued right now?
Based on GuruFocus' analysis, Oncolys BioPharma (TSE:4588) is currently considered Significantly Overvalued. The stock's GF Value™ is 円350.85, compared to a current price of 円4,950.00 — trading 1310.9% above its estimated fair value. The current EV-to-EBITDA is -157.52. Oncolys BioPharma's overall GF Score™ is 39/100 with 8 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is EV-to-EBITDA calculated?
EV-to-EBITDA is calculated from a company's financial statements. For Oncolys BioPharma (TSE:4588), the current EV-to-EBITDA is -157.52 as of Sep. 08, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is Oncolys BioPharma (TSE:4588) Overvalued in 2026?

Based on GuruFocus' analysis, Oncolys BioPharma stock appears to be overvalued. The current stock price of 円4,950.00 is trading 1310.9% above its estimated GF Value™ of 円350.85. GuruFocus considers Oncolys BioPharma to be Significantly Overvalued.

Key valuation signals for TSE:4588:

  • EV-to-EBITDA: -157.52
  • GF Value™: 円350.85 vs. price of 円4,950.00 (1310.9% above fair value)
  • GF Score™: 39/100 with 8 warning signs

No single metric tells the full story. See the TSE:4588 stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


Oncolys BioPharma Business Description

Address 4-1-28 Toranomon, Toranomon Towers Office, Minato-ku, Tokyo, JPN, 105-0001
Oncolys BioPharma Inc develops pharmaceutical products. The company is a biopharmaceutical company focused on developing therapies for cancer treatment. Their product pipeline includes various drug candidates such as Telomelysin (OBP-301) and OBP-702, aimed at addressing unmet medical needs in oncology. The company targets healthcare providers and institutions involved in cancer care and research.
39GF Score

Get the complete analysis for TSE:4588

EV-to-EBITDA is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

円4,950.00
Price
円350.85
GF Value