Oncolys BioPharma (TSE:4588) Piotroski F-Score: 3 (As of Jul. 14, 2026) — Near Median

Author: Vera Yuan Vera Yuan
Vera Yuan
Vera Yuan
Director of Data and Quant Analytics at GuruFocus
Focused on building reliable datasets, financial models, and research tools for value-minded investors. Committed to turning complex data into practical guidance for value-investing and long-term wealth.
Reviewed by: Charlie Tian Charlie Tian
Charlie Tian
Charlie Tian
Founder & CEO of GuruFocus
Dr. Charlie Tian is the founder and CEO of GuruFocus.com, a leading global investment research platform established in 2004. With a Ph.D. in physics, Dr. Tian transitioned from science to finance, applying a data-driven, disciplined approach to value investing.

TSE:4588 Oncolys BioPharma Inc TSE:4588
40 GF Score
Price 円2,522.00
GF Value 円363.33
Valuation Significantly Overvalued
! 5 Warning Signs
View Full Analysis

What is Oncolys BioPharma Piotroski F-Score?

Oncolys BioPharma TSE:4588 -2.06% 40 Piotroski F-Score is 3 as of Jul. 14, 2026, which is at its 10-year median of 3.00. GuruFocus rates TSE:4588 with a GF Score™ of 40/100 and a GF Value™ of 円363.33 (Significantly Overvalued). The stock has 5 warning signs investors should review. Among 1,333 Biotechnology companies, Oncolys BioPharma ranks better than 54.69% on this metric.

Warning Sign:

Piotroski F-Score of 3 is low, which usually implies poor business operation.

The zones of discrimination were as such:

Good or high score = 7, 8, 9
Bad or low score = 0, 1, 2, 3

Oncolys BioPharma has an F-score of 3. It is a bad or low score, which usually implies poor business operation.

The historical rank and industry rank for Oncolys BioPharma's Piotroski F-Score or its related term are showing as below:

TSE:4588' s Piotroski F-Score Range Over the Past 10 Years
Min: 1   Med: 3   Max: 4
Current: 3

During the past 13 years, the highest Piotroski F-Score of Oncolys BioPharma was 4. The lowest was 1. And the median was 3.

Oncolys BioPharma  (TSE:4588) Piotroski F-Score Explanation

The developer of the system is Joseph D. Piotroski is relatively unknown accounting professor who shuns publicity and rarely gives interviews.

He graduated from the University of Illinois with a B.S. in accounting in 1989, received an M.B.A. from Indiana University in 1994. Five years later, in 1999, after earning a Ph.D. in accounting from the University of Michigan, he became an associate professor of accounting at the University of Chicago.

In 2000, he wrote a research paper called "Value Investing: The Use of Historical Financial Statement Information to Separate Winners from Losers" (pdf).

He wanted to see if he can develop a system (using a simple nine-point scoring system) that can increase the returns of a strategy of investing in low price to book (referred to in the paper as high book to market) value companies.

What he found was something that exceeded his most optimistic expectations.

Buying only those companies that scored highest (8 or 9) on his nine-point scale, or F-Score as he called it, over the 20 year period from 1976 to 1996 led to an average out-performance over the market of 13.4%.

Even more impressive were the results of a strategy of investing in the highest F-Score companies (8 or 9) and shorting companies with the lowest F-Score (0 or 1).

Over the same period from 1976 to 1996 (20 years) this strategy led to an average yearly return of 23%, substantially outperforming the average S&P 500 index return of 15.83% over the same period.


Oncolys BioPharma Piotroski F-Score Related Terms


Oncolys BioPharma Piotroski F-Score Historical Data

* Premium members only.

The historical data trend for Oncolys BioPharma's Piotroski F-Score can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Oncolys BioPharma Piotroski F-Score Chart

Oncolys BioPharma Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
Piotroski F-Score
Get a 7-Day Free Trial Premium Member Only Premium Member Only 3.00 3.00 2.00 3.00 3.00

Oncolys BioPharma Quarterly Data
Dec20 Mar21 Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Dec24 Mar25 Jun25 Dec25 Mar26
Piotroski F-Score Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only 3.00 0.00 0.00 3.00 0.00

TSE:4588 vs VRTX, REGN, ALNY: Piotroski F-Score Comparison

For the Biotechnology subindustry, Oncolys BioPharma's Piotroski F-Score, along with its competitors' market caps and Piotroski F-Score data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Oncolys BioPharma Piotroski F-Score vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Oncolys BioPharma's Piotroski F-Score distribution charts can be found below:

* The bar in red indicates where Oncolys BioPharma's Piotroski F-Score falls into.


TSE:4588
40GF Score
Oncolys BioPharma Inc TSE:4588
Piotroski F-Score is just one metric. See GF Score™, valuation, warning signs, and more.
View Full Analysis

How is the Piotroski F-Score calculated?

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

This Year (Dec25) TTM:Last Year (Dec24) TTM:
Net Income was 円-2,058.05 Mil.
Cash Flow from Operations was 円-1,940.87 Mil.
Revenue was 円28.55 Mil.
Gross Profit was 円28.55 Mil.
Average Total Assets from the begining of this year (Dec24)
to the end of this year (Dec25) was (3198.858 + 4555.879) / 2 = 円3877.3685 Mil.
Total Assets at the begining of this year (Dec24) was 円3,198.86 Mil.
Long-Term Debt & Capital Lease Obligation was 円76.38 Mil.
Total Current Assets was 円4,494.35 Mil.
Total Current Liabilities was 円470.72 Mil.
Net Income was 円-1,684.78 Mil.

Revenue was 円31.38 Mil.
Gross Profit was 円31.38 Mil.
Average Total Assets from the begining of last year (Dec23)
to the end of last year (Dec24) was (2040.598 + 3198.858) / 2 = 円2619.728 Mil.
Total Assets at the begining of last year (Dec23) was 円2,040.60 Mil.
Long-Term Debt & Capital Lease Obligation was 円186.69 Mil.
Total Current Assets was 円3,098.24 Mil.
Total Current Liabilities was 円252.39 Mil.

*Note: If the latest quarterly/semi-annual/annual total assets data is 0, then we will use previous quarterly/semi-annual/annual data for all the items in the balance sheet.

Profitability

Question 1. Return on Assets (ROA)

Net income before extraordinary items for the year divided by Total Assets at the beginning of the year.

Score 1 if positive, 0 if negative.

Oncolys BioPharma's current Net Income (TTM) was -2,058.05. ==> Negative ==> Score 0.

Question 2. Cash Flow Return on Assets (CFROA)

Net cash flow from operating activities (operating cash flow) divided by Total Assets at the beginning of the year.

Score 1 if positive, 0 if negative.

Oncolys BioPharma's current Cash Flow from Operations (TTM) was -1,940.87. ==> Negative ==> Score 0.

Question 3. Change in Return on Assets

Compare this year's return on assets (1) to last year's return on assets.

Score 1 if it's higher, 0 if it's lower.

ROA (This Year)=Net Income/Total Assets (Dec24)
=-2058.049/3198.858
=-0.64336992

ROA (Last Year)=Net Income/Total Assets (Dec23)
=-1684.778/2040.598
=-0.82562955

Oncolys BioPharma's return on assets of this year was -0.64336992. Oncolys BioPharma's return on assets of last year was -0.82562955. ==> This year is higher. ==> Score 1.

Question 4. Quality of Earnings (Accrual)

Compare Cash flow return on assets (2) to return on assets (1)

Score 1 if CFROA > ROA, 0 if CFROA <= ROA.

Oncolys BioPharma's current Net Income (TTM) was -2,058.05. Oncolys BioPharma's current Cash Flow from Operations (TTM) was -1,940.87. ==> -1,940.87 > -2,058.05 ==> CFROA > ROA ==> Score 1.

Funding

Question 5. Change in Gearing or Leverage

Compare this year's gearing (long-term debt divided by average total assets) to last year's gearing.

Score 0 if this year's gearing is higher, 1 otherwise.

Gearing (This Year: Dec25)=Long-Term Debt & Capital Lease Obligation/Average Total Assets from Dec24 to Dec25
=76.376/3877.3685
=0.0196979

Gearing (Last Year: Dec24)=Long-Term Debt & Capital Lease Obligation/Average Total Assets from Dec23 to Dec24
=186.687/2619.728
=0.07126198

Oncolys BioPharma's gearing of this year was 0.0196979. Oncolys BioPharma's gearing of last year was 0.07126198. ==> This year is lower or equal to last year. ==> Score 1.

Question 6. Change in Working Capital (Liquidity)

Compare this year's current ratio (current assets divided by current liabilities) to last year's current ratio.

Score 1 if this year's current ratio is higher, 0 if it's lower

Current Ratio (This Year: Dec25)=Total Current Assets/Total Current Liabilities
=4494.353/470.721
=9.54780645

Current Ratio (Last Year: Dec24)=Total Current Assets/Total Current Liabilities
=3098.244/252.39
=12.27562106

Oncolys BioPharma's current ratio of this year was 9.54780645. Oncolys BioPharma's current ratio of last year was 12.27562106. ==> Last year's current ratio is higher ==> Score 0.

Question 7. Change in Shares in Issue

Compare the number of shares in issue this year, to the number in issue last year.

Score 0 if there is larger number of shares in issue this year, 1 otherwise.

Oncolys BioPharma's number of shares in issue this year was 25.726. Oncolys BioPharma's number of shares in issue last year was 21.831. ==> There is larger number of shares in issue this year. ==> Score 0.

Efficiency

Question 8. Change in Gross Margin

Compare this year's gross margin (Gross Profit divided by sales) to last year's.

Score 1 if this year's gross margin is higher, 0 if it's lower.

Gross Margin (This Year: TTM)=Gross Profit/Revenue
=28.546/28.546
=1

Gross Margin (Last Year: TTM)=Gross Profit/Revenue
=31.384/31.384
=1

Oncolys BioPharma's gross margin of this year was 1. Oncolys BioPharma's gross margin of last year was 1. ==> Last year's gross margin is higher ==> Score 0.

Question 9. Change in asset turnover

Compare this year's asset turnover (total sales for the year divided by total assets at the beginning of the year) to last year's asset turnover ratio.

Score 1 if this year's asset turnover ratio is higher, 0 if it's lower

Asset Turnover (This Year)=Revenue/Total Assets at the Beginning of This Year (Dec24)
=28.546/3198.858
=0.00892381

Asset Turnover (Last Year)=Revenue/Total Assets at the Beginning of Last Year (Dec23)
=31.384/2040.598
=0.01537981

Oncolys BioPharma's asset turnover of this year was 0.00892381. Oncolys BioPharma's asset turnover of last year was 0.01537981. ==> Last year's asset turnover is higher ==> Score 0.

Evaluation

Piotroski F-Score= Que. 1+ Que. 2+ Que. 3+Que. 4+Que. 5+Que. 6+Que. 7+Que. 8+Que. 9
=0+0+1+1+1+0+0+0+0
=3

Good or high score = 7, 8, 9
Bad or low score = 0, 1, 2, 3

Oncolys BioPharma has an F-score of 3. It is a bad or low score, which usually implies poor business operation.

Frequently Asked Questions Learn more about Piotroski F-Score →
What does a Piotroski F-Score of 3 mean?
Oncolys BioPharma (TSE:4588) has a Piotroski F-Score of 3 as of Jul. 14, 2026. The Piotroski F-score grades a company's business operating strength from 0-9. View historical data on Oncolys BioPharma and its competitors. This is near median its historical median of 3.00. Over the past decade, Oncolys BioPharma's Piotroski F-Score has ranged from 1.00 to 4.00. According to the industry distribution chart, Oncolys BioPharma ranks #604 out of 1333 companies in the Biotechnology industry, placing it in the top 45.3%.
Is Oncolys BioPharma's Piotroski F-Score too high?
Oncolys BioPharma's current Piotroski F-Score of 3 is near median its 10-year median of 3.00. Over the past 10 years, this metric has ranged from a low of 1.00 to a high of 4.00. The Biotechnology industry median Piotroski F-Score is 3.00. Oncolys BioPharma's value of 3 is 0% at this industry median. Based on the distribution chart, Oncolys BioPharma ranks #604 out of 1333 companies in the Biotechnology industry, which is above the industry midpoint. Overall, Oncolys BioPharma has a GF Score™ of 40/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Oncolys BioPharma's Piotroski F-Score compare to VRTX and REGN?
According to the Biotechnology industry distribution chart, Oncolys BioPharma ranks #604 out of 1333 companies for Piotroski F-Score. This puts Oncolys BioPharma in the upper half of its industry. The industry median Piotroski F-Score is 3.00. Oncolys BioPharma's value of 3 is 0% at this benchmark. Historically, Oncolys BioPharma's own Piotroski F-Score has ranged from 1.00 to 4.00 over the past decade. While the company's 10-year median is 3.00 vs. the industry median of 3.00, Oncolys BioPharma has consistently been at the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Piotroski F-Score for a Biotechnology company?
The median Piotroski F-Score among Biotechnology companies is 3.00, based on 1,333 companies in the industry. Companies in the top quartile (top 25%) have a Piotroski F-Score significantly above this median, while those in the bottom quartile fall well below. However, Piotroski F-Score should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Oncolys BioPharma's current Piotroski F-Score of 3 is 0% at the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Piotroski F-Score mean?
A high Piotroski F-Score can signal that a stock is expensive relative to its fundamentals. The Piotroski F-score grades a company's business operating strength from 0-9. View historical data on Oncolys BioPharma and its competitors. For the Biotechnology industry, the median Piotroski F-Score is 3.00 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Oncolys BioPharma's current Piotroski F-Score is 3, which is near median its own 10-year median of 3.00. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Oncolys BioPharma stock overvalued right now?
Based on GuruFocus' analysis, Oncolys BioPharma (TSE:4588) is currently considered Significantly Overvalued. The stock's GF Value™ is 円363.33, compared to a current price of 円2,522.00 — trading 594.1% above its estimated fair value. The current Piotroski F-Score is 3, which is near median its 10-year median of 3.00 and 0% at the Biotechnology industry median of 3.00. Oncolys BioPharma's overall GF Score™ is 40/100 with 5 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Piotroski F-Score calculated?
Piotroski F-Score is calculated from a company's financial statements. For Oncolys BioPharma (TSE:4588), the current Piotroski F-Score is 3 as of Jul. 14, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is Oncolys BioPharma (TSE:4588) Overvalued in 2026?

Based on GuruFocus' analysis, Oncolys BioPharma stock appears to be overvalued. The current stock price of 円2,522.00 is trading 594.1% above its estimated GF Value™ of 円363.33. GuruFocus considers Oncolys BioPharma to be Significantly Overvalued.

Key valuation signals for TSE:4588:

  • Piotroski F-Score: 3 (near median its 10-year median of 3.00)
  • GF Value™: 円363.33 vs. price of 円2,522.00 (594.1% above fair value)
  • GF Score™: 40/100 with 5 warning signs
  • Industry Position: 0% at the Biotechnology median (#604 of 1333)

No single metric tells the full story. See the TSE:4588 stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


Oncolys BioPharma Business Description

Address 4-1-28 Toranomon, Toranomon Towers Office, Minato-ku, Tokyo, JPN, 105-0001
Oncolys BioPharma Inc develops pharmaceutical products. The company is a biopharmaceutical company focused on developing therapies for cancer treatment. Their product pipeline includes various drug candidates such as Telomelysin (OBP-301) and OBP-702, aimed at addressing unmet medical needs in oncology. The company targets healthcare providers and institutions involved in cancer care and research.
40GF Score

Get the complete analysis for TSE:4588

Piotroski F-Score is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

円2,522.00
Price
円363.33
GF Value