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Denali TherapeuticsSTU:4DN +4.78%39 Piotroski F-Score is 3 as of Aug. 20, 2026, which is at its 10-year median of 3.00. GuruFocus rates STU:4DN with a GF Score™ of 39/100. The stock has 6 warning signs investors should review. Among 1,335 Biotechnology companies, Denali Therapeutics ranks better than 54.16% on this metric.
Warning Sign:
Piotroski F-Score of 3 is low, which usually implies poor business operation.
The zones of discrimination were as such:
Good or high score = 7, 8, 9
Bad or low score = 0, 1, 2, 3
Denali Therapeutics has an F-score of 4 indicating the company's financial situation is typical for a stable company.
The historical rank and industry rank for Denali Therapeutics's Piotroski F-Score or its related term are showing as below:
STU:4DN'
s Piotroski F-Score Range Over the Past 10 Years
Min: 1 Med: 3 Max: 7
Current: 3
During the past 11 years, the highest Piotroski F-Score of Denali Therapeutics was 7. The lowest was 1. And the median was 3.
The developer of the system is Joseph D. Piotroski is relatively unknown accounting professor who shuns publicity and rarely gives interviews.
He graduated from the University of Illinois with a B.S. in accounting in 1989, received an M.B.A. from Indiana University in 1994. Five years later, in 1999, after earning a Ph.D. in accounting from the University of Michigan, he became an associate professor of accounting at the University of Chicago.
He wanted to see if he can develop a system (using a simple nine-point scoring system) that can increase the returns of a strategy of investing in low price to book (referred to in the paper as high book to market) value companies.
What he found was something that exceeded his most optimistic expectations.
Buying only those companies that scored highest (8 or 9) on his nine-point scale, or F-Score as he called it, over the 20 year period from 1976 to 1996 led to an average out-performance over the market of 13.4%.
Even more impressive were the results of a strategy of investing in the highest F-Score companies (8 or 9) and shorting companies with the lowest F-Score (0 or 1).
Over the same period from 1976 to 1996 (20 years) this strategy led to an average yearly return of 23%, substantially outperforming the average S&P 500 index return of 15.83% over the same period.
Denali Therapeutics Piotroski F-Score Related Terms
Denali Therapeutics Piotroski F-Score Historical Data
* Premium members only.
The historical data trend for Denali Therapeutics's Piotroski F-Score can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
STU:4DN vs RCUS, ALMS, ELVN: Piotroski F-Score Comparison
For the Biotechnology subindustry, Denali Therapeutics's Piotroski F-Score, along with its competitors' market caps and Piotroski F-Score data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Denali Therapeutics Piotroski F-Score vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Denali Therapeutics's Piotroski F-Score distribution charts can be found below:
* The bar in red indicates where Denali Therapeutics's Piotroski F-Score falls into.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
*Note: If the latest quarterly/semi-annual/annual total assets data is 0, then we will use previous quarterly/semi-annual/annual data for all the items in the balance sheet.
Profitability
Question 1. Return on Assets (ROA)
Net income before extraordinary items for the year divided by Total Assets at the beginning of the year.
Score 1 if positive, 0 if negative.
Denali Therapeutics's current Net Income (TTM) was -439.73.
==> Negative ==> Score 0.
Question 2. Cash Flow Return on Assets (CFROA)
Net cash flow from operating activities (operating cash flow) divided by Total Assets at the beginning of the year.
Score 1 if positive, 0 if negative.
Denali Therapeutics's current Cash Flow from Operations (TTM) was -373.26.
==> Negative ==> Score 0.
Question 3. Change in Return on Assets
Compare this year's return on assets (1) to last year's return on assets.
Denali Therapeutics's return on assets of this year was -0.4348843. Denali Therapeutics's return on assets of last year was -0.31290373.
==> Last year is higher ==> Score 0.
Question 4. Quality of Earnings (Accrual)
Compare Cash flow return on assets (2) to return on assets (1)
Denali Therapeutics's gearing of this year was 0.01916331. Denali Therapeutics's gearing of last year was 0.02632782.
==> This year is lower or equal to last year. ==> Score 1.
Question 6. Change in Working Capital (Liquidity)
Compare this year's current ratio (current assets divided by current liabilities) to last year's current ratio.
Score 1 if this year's current ratio is higher, 0 if it's lower
Denali Therapeutics's current ratio of this year was 8.36925772. Denali Therapeutics's current ratio of last year was 10.26511793.
==> Last year's current ratio is higher ==> Score 0.
Question 7. Change in Shares in Issue
Compare the number of shares in issue this year, to the number in issue last year.
Score 0 if there is larger number of shares in issue this year, 1 otherwise.
Denali Therapeutics's number of shares in issue this year was 187.315. Denali Therapeutics's number of shares in issue last year was 171.45.
==> There is larger number of shares in issue this year. ==> Score 0.
Efficiency
Question 8. Change in Gross Margin
Compare this year's gross margin (Gross Profit divided by sales) to last year's.
Score 1 if this year's gross margin is higher, 0 if it's lower.
Denali Therapeutics's gross margin of this year was 0.97442455. Denali Therapeutics's gross margin of last year was .
==> This year's gross margin is higher. ==> Score 1.
Question 9. Change in asset turnover
Compare this year's asset turnover (total sales for the year divided by total assets at the beginning of the year) to last year's asset turnover ratio.
Score 1 if this year's asset turnover ratio is higher, 0 if it's lower
Denali Therapeutics's asset turnover of this year was 0.00309357. Denali Therapeutics's asset turnover of last year was 0.
==> This year's asset turnover is higher. ==> Score 1.
Evaluation
Piotroski F-Score
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Good or high score = 7, 8, 9
Bad or low score = 0, 1, 2, 3
Denali Therapeutics has an F-score of 4 indicating the company's financial situation is typical for a stable company.
Denali Therapeutics (STU:4DN) has a Piotroski F-Score of 3 as of Aug. 20, 2026. The Piotroski F-score grades a company's business operating strength from 0-9. View historical data on Denali Therapeutics and its competitors. This is near median its historical median of 3.00. Over the past decade, Denali Therapeutics' Piotroski F-Score has ranged from 1.00 to 7.00. According to the industry distribution chart, Denali Therapeutics ranks #612 out of 1335 companies in the Biotechnology industry, placing it in the top 45.8%.
Is Denali Therapeutics' Piotroski F-Score too high?
Denali Therapeutics' current Piotroski F-Score of 3 is near median its 10-year median of 3.00. Over the past 10 years, this metric has ranged from a low of 1.00 to a high of 7.00. The Biotechnology industry median Piotroski F-Score is 3.00. Denali Therapeutics' value of 3 is 0% at this industry median. Based on the distribution chart, Denali Therapeutics ranks #612 out of 1335 companies in the Biotechnology industry, which is above the industry midpoint. Overall, Denali Therapeutics has a GF Score™ of 39/100, reflecting its overall financial health beyond just this single metric.
How does Denali Therapeutics' Piotroski F-Score compare to RCUS and ALMS?
According to the Biotechnology industry distribution chart, Denali Therapeutics ranks #612 out of 1335 companies for Piotroski F-Score. This puts Denali Therapeutics in the upper half of its industry. The industry median Piotroski F-Score is 3.00. Denali Therapeutics' value of 3 is 0% at this benchmark. Historically, Denali Therapeutics' own Piotroski F-Score has ranged from 1.00 to 7.00 over the past decade. While the company's 10-year median is 3.00 vs. the industry median of 3.00, Denali Therapeutics has consistently been at the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Piotroski F-Score for a Biotechnology company?
The median Piotroski F-Score among Biotechnology companies is 3.00, based on 1,335 companies in the industry. Companies in the top quartile (top 25%) have a Piotroski F-Score significantly above this median, while those in the bottom quartile fall well below. However, Piotroski F-Score should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Denali Therapeutics's current Piotroski F-Score of 3 is 0% at the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Piotroski F-Score mean?
A high Piotroski F-Score can signal that a stock is expensive relative to its fundamentals. The Piotroski F-score grades a company's business operating strength from 0-9. View historical data on Denali Therapeutics and its competitors. For the Biotechnology industry, the median Piotroski F-Score is 3.00 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Denali Therapeutics's current Piotroski F-Score is 3, which is near median its own 10-year median of 3.00. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Denali Therapeutics stock overvalued right now?
Denali Therapeutics (STU:4DN) has a current Piotroski F-Score of 3. The current Piotroski F-Score is 3, which is near median its 10-year median of 3.00 and 0% at the Biotechnology industry median of 3.00. Denali Therapeutics' overall GF Score™ is 39/100 with 6 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Piotroski F-Score calculated?
Piotroski F-Score is calculated from a company's financial statements. For Denali Therapeutics (STU:4DN), the current Piotroski F-Score is 3 as of Aug. 20, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Denali Therapeutics Inc is a biotechnology company that is engaged in developing and discovering therapeutics to defeat neurodegenerative diseases. The company's development programs include the LRRK2 Inhibitor Program, which develops brain penetrant small molecule LRRK2 inhibitor product candidates for Parkinson's disease. Its key products include DNL201, DNL151, ATV (Antibody Transport Vehicle), ETV (Enzyme Transport Vehicle), and others. The Company has one operating segment with the goal to discover, develop, and commercializing therapeutics.
39GF Score
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