Denali Therapeutics (STU:4DN) OCF Yield %: -10.57 (As of Aug. 20, 2026)

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STU:4DN Denali Therapeutics Inc STU:4DN
39 GF Score
Price €21.91
Valuation Significantly Overvalued
! 6 Warning Signs
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What is Denali Therapeutics OCF Yield %?

Denali Therapeutics STU:4DN +4.78% 39 OCF Yield % is -10.57 as of Aug. 20, 2026. GuruFocus rates STU:4DN with a GF Score™ of 39/100 (Significantly Overvalued). The stock has 6 warning signs investors should review. Among 1,410 Biotechnology companies, Denali Therapeutics ranks worse than 55.25% on this metric.

OCF Yield % is calculated as Cash Flow from Operations divided by Market Capitalization. It is a financial solvency ratio that compares the operating cash flow a company is expected to earn against its market value.

As of today, Denali Therapeutics's Trailing 12-Month Cash Flow from Operations is €-373.26 Mil, and Market Cap is €3,547.44 Mil. Therefore, Denali Therapeutics's OCF Yield % for today is -10.57%.

The historical rank and industry rank for Denali Therapeutics's OCF Yield % or its related term are showing as below:

STU:4DN' s OCF Yield % Range Over the Past 10 Years
Min: -19.65   Med: -6.42   Max: 7.1
Current: -10.57


During the past 11 years, the highest OCF Yield % of Denali Therapeutics was 7.10%. The lowest was -19.65%. And the median was -6.42%.

STU:4DN's OCF Yield % is ranked worse than
55.25% of 1410 companies
in the Biotechnology industry
Industry Median: -8.375 vs STU:4DN: -10.57

Denali Therapeutics's OCF Margin % for the quarter that ended in Jun. 2026 was %.


Denali Therapeutics OCF Yield % Explanation

Similar to Earnings Yield %, OCF Yield % is financial solvency ratio. A lower ratio suggests a less attractive investment, indicating that investors might not receive substantial returns in proportion to their investment. Conversely, a high operating cash flow yield signals that a company generates sufficient cash to comfortably meet its debts, obligations, and dividend payments, making it a promising investment choice.


Denali Therapeutics OCF Yield % Related Terms


Denali Therapeutics OCF Yield % Historical Data

* Premium members only.

The historical data trend for Denali Therapeutics's OCF Yield % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Denali Therapeutics OCF Yield % Chart

Denali Therapeutics Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
OCF Yield %
Get a 7-Day Free Trial Premium Member Only Premium Member Only -3.96 -6.54 -12.03 -11.80 -16.20

Denali Therapeutics Quarterly Data
Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26 Jun26
OCF Yield % Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -15.16 -20.37 -15.48 -17.23 -9.37

STU:4DN vs RCUS, ALMS, ELVN: OCF Yield % Comparison

For the Biotechnology subindustry, Denali Therapeutics's OCF Yield %, along with its competitors' market caps and OCF Yield % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Denali Therapeutics OCF Yield % vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Denali Therapeutics's OCF Yield % distribution charts can be found below:

* The bar in red indicates where Denali Therapeutics's OCF Yield % falls into.


STU:4DN
39GF Score
Denali Therapeutics Inc STU:4DN
OCF Yield % is just one metric. See GF Score™, valuation, warning signs, and more.
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Denali Therapeutics OCF Yield % Calculation

OCF Yield % is a financial solvency ratio that compares the operating cash flow a company is expected to earn against its market value.

Denali Therapeutics's OCF Yield % for the fiscal year that ended in Dec. 2025 is calculated as

OCF Yield %=Cash Flow from Operations / Market Cap
=-352.36 / 2174.83435
=-16.20%

Denali Therapeutics's annualized OCF Yield % for the quarter that ended in Jun. 2026 is calculated as

OCF Yield %=Cash Flow from Operations * Annualized Factor / Market Cap
=-84.198 * 4 / 3596.10756
=-9.37%

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Frequently Asked Questions Learn more about OCF Yield % →
What does a OCF Yield % of -10.57 mean?
Denali Therapeutics (STU:4DN) has a OCF Yield % of -10.57 as of Aug. 20, 2026. OCF Yield is calculated as Cash Flow from Operations divided by Market Capitalization. View historical data on Denali Therapeutics and its competitors. According to the industry distribution chart, Denali Therapeutics ranks #779 out of 1410 companies in the Biotechnology industry, placing it in the top 55.2%.
Is Denali Therapeutics' OCF Yield % too high?
Denali Therapeutics' current OCF Yield % is -10.57. Based on the distribution chart, Denali Therapeutics ranks #779 out of 1410 companies in the Biotechnology industry, which is below the industry midpoint. Overall, Denali Therapeutics has a GF Score™ of 39/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Denali Therapeutics' OCF Yield % compare to RCUS and ALMS?
According to the Biotechnology industry distribution chart, Denali Therapeutics ranks #779 out of 1410 companies for OCF Yield %. This places Denali Therapeutics in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good OCF Yield % for a Biotechnology company?
A good OCF Yield % depends on the Biotechnology industry context. However, OCF Yield % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high OCF Yield % mean?
A high OCF Yield % can signal that a stock is expensive relative to its fundamentals. OCF Yield is calculated as Cash Flow from Operations divided by Market Capitalization. View historical data on Denali Therapeutics and its competitors. Denali Therapeutics's current OCF Yield % is -10.57. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Denali Therapeutics stock overvalued right now?
Based on GuruFocus' analysis, Denali Therapeutics (STU:4DN) is currently considered Significantly Overvalued. The current OCF Yield % is -10.57. Denali Therapeutics' overall GF Score™ is 39/100 with 6 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is OCF Yield % calculated?
OCF Yield % is calculated from a company's financial statements. For Denali Therapeutics (STU:4DN), the current OCF Yield % is -10.57 as of Aug. 20, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Denali Therapeutics Business Description

Other Exchanges DNLI:USAD2NL34:Brazil
Address 161 Oyster Point Boulevard, South San Francisco, CA, USA, 94080
Denali Therapeutics Inc is a biotechnology company that is engaged in developing and discovering therapeutics to defeat neurodegenerative diseases. The company's development programs include the LRRK2 Inhibitor Program, which develops brain penetrant small molecule LRRK2 inhibitor product candidates for Parkinson's disease. Its key products include DNL201, DNL151, ATV (Antibody Transport Vehicle), ETV (Enzyme Transport Vehicle), and others. The Company has one operating segment with the goal to discover, develop, and commercializing therapeutics.
39GF Score

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OCF Yield % is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

€21.91
Price