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Denali TherapeuticsSTU:4DN +4.78%39 Return-on-Tangible-Asset is -43.45% as of Jun. 2026. GuruFocus rates STU:4DN with a GF Score™ of 39/100 (Significantly Overvalued). The stock has 6 warning signs investors should review. Among 1,415 Biotechnology companies, Denali Therapeutics ranks worse than 56.54% on this metric.
Return-on-Tangible-Asset is calculated as Net Income divided by its average total tangible assets. Total tangible assets equals to Total Assets minus Intangible Assets. Denali Therapeutics's annualizedNet Income for the quarter that ended in Jun. 2026 was €-442.86 Mil. Denali Therapeutics's average total tangible assets for the quarter that ended in Jun. 2026 was €1,019.24 Mil. Therefore, Denali Therapeutics's annualized Return-on-Tangible-Asset for the quarter that ended in Jun. 2026 was -43.45%.
The historical rank and industry rank for Denali Therapeutics's Return-on-Tangible-Asset or its related term are showing as below:
STU:4DN'
s Return-on-Tangible-Asset Range Over the Past 10 Years
Min: -56.31 Med: -23.02 Max: 6.59
Current: -44.71
During the past 11 years, Denali Therapeutics's highest Return-on-Tangible-Asset was 6.59%. The lowest was -56.31%. And the median was -23.02%.
STU:4DN's Return-on-Tangible-Asset is ranked worse than 56.54% of 1415
companies
in the Biotechnology industry
Industry Median: -35.77
vs STU:4DN: -44.71
Return-on-Tangible-Asset measures the rate of return on the average total tangible assets (total assets minus intangible assets). Tangible means physical in nature. Intangible Assets are assets that are not physical in nature, and typically "derive their value from legal or intellectual rights." Return-on-Tangible-Asset measures a firm's efficiency at generating profits from its tangible assets. It shows how well a company uses what it has to generate earnings. Return-on-Tangible-Assets can vary drastically across industries. Therefore, Return-on-Tangible-Asset should not be used to compare companies in different industries.
Be Aware
Like ROE and ROA, Return-on-Tangible-Asset is calculated with only 12 months data. Fluctuations in the companys earnings or business cycles can affect the ratio drastically. It is important to look at the ratio from a long term perspective. Return-on-Tangible-Asset can be affected by events such as stock buyback or issuance, and by a companys tax rate and its interest payment. Return-on-Tangible-Asset may not reflect the true earning power of the assets. A more accurate measurement is ROC % (ROC).
Many analysts argue the higher return the better. Buffett states that really high Return-on-Tangible-Asset may indicate vulnerability in the durability of the competitive advantage.
Denali Therapeutics Return-on-Tangible-Asset Related Terms
Denali Therapeutics Return-on-Tangible-Asset Historical Data
* Premium members only.
The historical data trend for Denali Therapeutics's Return-on-Tangible-Asset can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
STU:4DN vs RCUS, ALMS, ELVN: Return-on-Tangible-Asset Comparison
For the Biotechnology subindustry, Denali Therapeutics's Return-on-Tangible-Asset, along with its competitors' market caps and Return-on-Tangible-Asset data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Denali Therapeutics Return-on-Tangible-Asset vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Denali Therapeutics's Return-on-Tangible-Asset distribution charts can be found below:
* The bar in red indicates where Denali Therapeutics's Return-on-Tangible-Asset falls into.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
In the calculation of annual Return-on-Tangible-Asset, the net income of the last fiscal year and the average total tangible assets over the fiscal year are used. In calculating the quarterly data,
the Net Income data used here is four times the quarterly (Jun. 2026) net income data.
What does a Return-on-Tangible-Asset of -43.45% mean?
Denali Therapeutics (STU:4DN) has a Return-on-Tangible-Asset of -43.45% as of Jun. 2026. Return on tangible assets is the ratio of current-period net income to average two-period tangible assets. View historical data on Denali Therapeutics and its competitors. According to the industry distribution chart, Denali Therapeutics ranks #800 out of 1415 companies in the Biotechnology industry, placing it in the top 56.5%.
Is Denali Therapeutics' Return-on-Tangible-Asset too high?
Denali Therapeutics' current Return-on-Tangible-Asset is -43.45%. Based on the distribution chart, Denali Therapeutics ranks #800 out of 1415 companies in the Biotechnology industry, which is below the industry midpoint. Overall, Denali Therapeutics has a GF Score™ of 39/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Denali Therapeutics' Return-on-Tangible-Asset compare to RCUS and ALMS?
According to the Biotechnology industry distribution chart, Denali Therapeutics ranks #800 out of 1415 companies for Return-on-Tangible-Asset. This places Denali Therapeutics in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Return-on-Tangible-Asset for a Biotechnology company?
A good Return-on-Tangible-Asset depends on the Biotechnology industry context. However, Return-on-Tangible-Asset should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Return-on-Tangible-Asset mean?
A high Return-on-Tangible-Asset can signal that a stock is expensive relative to its fundamentals. Return on tangible assets is the ratio of current-period net income to average two-period tangible assets. View historical data on Denali Therapeutics and its competitors. Denali Therapeutics's current Return-on-Tangible-Asset is -43.45%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Denali Therapeutics stock overvalued right now?
Based on GuruFocus' analysis, Denali Therapeutics (STU:4DN) is currently considered Significantly Overvalued. The current Return-on-Tangible-Asset is -43.45%. Denali Therapeutics' overall GF Score™ is 39/100 with 6 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Return-on-Tangible-Asset calculated?
Return-on-Tangible-Asset is calculated from a company's financial statements. For Denali Therapeutics (STU:4DN), the current Return-on-Tangible-Asset is -43.45% as of Jun. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Denali Therapeutics Inc is a biotechnology company that is engaged in developing and discovering therapeutics to defeat neurodegenerative diseases. The company's development programs include the LRRK2 Inhibitor Program, which develops brain penetrant small molecule LRRK2 inhibitor product candidates for Parkinson's disease. Its key products include DNL201, DNL151, ATV (Antibody Transport Vehicle), ETV (Enzyme Transport Vehicle), and others. The Company has one operating segment with the goal to discover, develop, and commercializing therapeutics.
39GF Score
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