HumacyteHUMA -2.68%21 Operating Margin % is -5,845.45% as of Mar. 2026. GuruFocus rates HUMA with a GF Score™ of 21/100. The stock has 6 warning signs investors should review. Among 945 Biotechnology companies, Humacyte ranks worse than 90.48% on this metric.
Operating Margin % is calculated as Operating Income divided by its Revenue. Humacyte's Operating Income for the
three
months ended in Mar. 2026 was $-28.94 Mil. Humacyte's Revenue for the
three
months ended in Mar. 2026 was $0.50 Mil. Therefore, Humacyte's Operating Margin % for the quarter that ended in Mar. 2026 was -5,845.45%.
The historical rank and industry rank for Humacyte's Operating Margin % or its related term are showing as below:
HUMA'
s Operating Margin % Range Over the Past 10 Years
Min: -5649.21 Med: -5306.04 Max: -5306.04
Current: -5649.21
HUMA's Operating Margin % is ranked worse than 90.48% of 945
companies
in the Biotechnology industry
Industry Median: -86.89
vs HUMA: -5649.21
Humacyte's 5-Year Average Operating Margin % Growth Rate was 0.00% per year.
Humacyte's Operating Income for the
three
months ended in Mar. 2026 was $-28.94 Mil.
Its Operating Income for the trailing twelve months (TTM) ended in Mar. 2026 was $-113.89 Mil.
Just like Gross Margin %, it is important to see a company maintains its operating margin over time. Among the same industry, a company with higher operating margin is more efficient in its operation. It is also more stable during industry slowdown or recessions. Peter Lynch prefers those with higher margins than those with lower margins.
Be Aware
Operating Margin % can be manipulated by adjusting the rate of depreciation, depletion and amortization (DDA).
If a company is facing competition, its Operating Margin % may decline. Often the Operating Margin % declines well before the company's Revenue or even profit decline. Therefore, Operating Margin % is a very important indicator of whether the company is facing problems.
For instance, by 2012, Nokia (NOK)'s problems were well known and its stock had lost more than 90% of its market value since 2007. But Nokias Operating Margin % had already been in decline since 2002, although its Earnings per Share (Diluted) were still rising. Investors who paid attention to Operating Margin % would have avoided this huge loss. The same can be said for Research-in-Motion (RIMM).
Therefore, Operating Margin % is a very important screening filter for GuruFocus. GuruFocus's Buffett-Munger screener requires that the profit margin is either consistent or expanding. The Model Portfolio of the Buffett-Munger screener has outperformed the market every year since inception in 2009.
Humacyte Operating Margin % Related Terms
Humacyte Operating Margin % Historical Data
* Premium members only.
The historical data trend for Humacyte's Operating Margin % can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
HUMA vs ZNTL, AVXL, ELDN: Operating Margin % Comparison
For the Biotechnology subindustry, Humacyte's Operating Margin %, along with its competitors' market caps and Operating Margin % data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Humacyte Operating Margin % vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Humacyte's Operating Margin % distribution charts can be found below:
* The bar in red indicates where Humacyte's Operating Margin % falls into.
Operating Margin % - also known as operating income margin, operating profit margin and return on sales (ROS) - is the ratio of Operating Income divided by net sales or Revenue, usually presented in percent.
Humacyte's Operating Margin % for the fiscal year that ended in Dec. 2025 is calculated as
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
What does a Operating Margin % of -5,845.45% mean?
Humacyte (HUMA) has a Operating Margin % of -5,845.45% as of Mar. 2026. Operating margin is the ratio of total operating income to net sales. View historical data on Humacyte and its competitors. According to the industry distribution chart, Humacyte ranks #855 out of 945 companies in the Biotechnology industry, placing it in the top 90.5%.
Is Humacyte's Operating Margin % too high?
Humacyte's current Operating Margin % is -5,845.45%. Based on the distribution chart, Humacyte ranks #855 out of 945 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, Humacyte has a GF Score™ of 21/100, reflecting its overall financial health beyond just this single metric.
How does Humacyte's Operating Margin % compare to ZNTL and AVXL?
According to the Biotechnology industry distribution chart, Humacyte ranks #855 out of 945 companies for Operating Margin %. This places Humacyte in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Operating Margin % for a Biotechnology company?
A good Operating Margin % depends on the Biotechnology industry context. However, Operating Margin % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Operating Margin % mean?
A high Operating Margin % can signal that a stock is expensive relative to its fundamentals. Operating margin is the ratio of total operating income to net sales. View historical data on Humacyte and its competitors. Humacyte's current Operating Margin % is -5,845.45%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Humacyte stock overvalued right now?
Humacyte (HUMA) has a current Operating Margin % of -5,845.45%. The current Operating Margin % is -5,845.45%. Humacyte's overall GF Score™ is 21/100 with 6 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Operating Margin % calculated?
Operating Margin % is calculated from a company's financial statements. For Humacyte (HUMA), the current Operating Margin % is -5,845.45% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Humacyte Inc is developing a commercial-stage biotechnology platform to deliver universally implantable bioengineered human tissues and organs designed to improve the lives of patients and transform the practice of medicine. It develops and manufactures acellular tissues to treat a wide range of diseases, injuries, and chronic conditions. Company's pipeline includes Vascular Trauma, PAD, Dailysis, Acellular Tissue Engineered Vessels, Organ Systems, Advanced Tissue Constructs.
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