RNA (Atrium Therapeutics) Operating Margin %: -88.01% (As of Mar. 2026)


RNA Atrium Therapeutics Inc RNA
12 GF Score
Price $12.80
! 1 Warning Sign
View Full Analysis

What is Atrium Therapeutics Operating Margin %?

Atrium Therapeutics RNA +0.16% 12 Operating Margin % is -88.01% as of Mar. 2026. GuruFocus rates RNA with a GF Score™ of 12/100. The stock has 1 warning sign investors should review. Among 945 Biotechnology companies, Atrium Therapeutics ranks worse than 64.87% on this metric.

Operating Margin % is calculated as Operating Income divided by its Revenue. Atrium Therapeutics's Operating Income for the three months ended in Mar. 2026 was $-17.28 Mil. Atrium Therapeutics's Revenue for the three months ended in Mar. 2026 was $19.64 Mil. Therefore, Atrium Therapeutics's Operating Margin % for the quarter that ended in Mar. 2026 was -88.01%.

The historical rank and industry rank for Atrium Therapeutics's Operating Margin % or its related term are showing as below:

RNA' s Operating Margin % Range Over the Past 10 Years
Min: -412.58   Med: -121.3   Max: -65.4
Current: -318.7


RNA's Operating Margin % is ranked worse than
64.87% of 945 companies
in the Biotechnology industry
Industry Median: -86.77 vs RNA: -318.70

Atrium Therapeutics's 5-Year Average Operating Margin % Growth Rate was 0.00% per year.

Atrium Therapeutics's Operating Income for the three months ended in Mar. 2026 was $-17.28 Mil. Its Operating Income for the trailing twelve months (TTM) ended in Mar. 2026 was $-65.32 Mil.


Atrium Therapeutics  (NAS:RNA) Operating Margin % Explanation

Just like Gross Margin %, it is important to see a company maintains its operating margin over time. Among the same industry, a company with higher operating margin is more efficient in its operation. It is also more stable during industry slowdown or recessions. Peter Lynch prefers those with higher margins than those with lower margins.


Be Aware

Operating Margin % can be manipulated by adjusting the rate of depreciation, depletion and amortization (DDA).

If a company is facing competition, its Operating Margin % may decline. Often the Operating Margin % declines well before the company's Revenue or even profit decline. Therefore, Operating Margin % is a very important indicator of whether the company is facing problems.

For instance, by 2012, Nokia (NOK)'s problems were well known and its stock had lost more than 90% of its market value since 2007. But Nokia’s Operating Margin % had already been in decline since 2002, although its Earnings per Share (Diluted) were still rising. Investors who paid attention to Operating Margin % would have avoided this huge loss. The same can be said for Research-in-Motion (RIMM).

Therefore, Operating Margin % is a very important screening filter for GuruFocus. GuruFocus's Buffett-Munger screener requires that the profit margin is either consistent or expanding. The Model Portfolio of the Buffett-Munger screener has outperformed the market every year since inception in 2009.


Atrium Therapeutics Operating Margin % Related Terms


Atrium Therapeutics Operating Margin % Historical Data

* Premium members only.

The historical data trend for Atrium Therapeutics's Operating Margin % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Atrium Therapeutics Operating Margin % Chart

Atrium Therapeutics Annual Data
Trend Dec23 Dec24 Dec25
Operating Margin %
-65.40 -121.30 -412.58

Atrium Therapeutics Quarterly Data
Dec23 Dec24 Mar25 Sep25 Dec25 Mar26
Operating Margin % Get a 7-Day Free Trial -210.26 -473.74 0.00 -5,591.97 -88.01

RNA vs RNAC, KROS, ARCT: Operating Margin % Comparison

For the Biotechnology subindustry, Atrium Therapeutics's Operating Margin %, along with its competitors' market caps and Operating Margin % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Atrium Therapeutics Operating Margin % vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Atrium Therapeutics's Operating Margin % distribution charts can be found below:

* The bar in red indicates where Atrium Therapeutics's Operating Margin % falls into.


RNA
12GF Score
Atrium Therapeutics Inc RNA
Operating Margin % is just one metric. See GF Score™, valuation, warning signs, and more.
View Full Analysis

Atrium Therapeutics Operating Margin % Calculation

Operating Margin % - also known as operating income margin, operating profit margin and return on sales (ROS) - is the ratio of Operating Income divided by net sales or Revenue, usually presented in percent.

Atrium Therapeutics's Operating Margin % for the fiscal year that ended in Dec. 2025 is calculated as

Operating Margin %=Operating Income (A: Dec. 2025 ) / Revenue (A: Dec. 2025 )
=-76.814 / 18.618
=-412.58 %

Atrium Therapeutics's Operating Margin % for the quarter that ended in Mar. 2026 is calculated as

Operating Margin %=Operating Income (Q: Mar. 2026 ) / Revenue (Q: Mar. 2026 )
=-17.28 / 19.635
=-88.01 %

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Frequently Asked Questions Learn more about Operating Margin % →
What does a Operating Margin % of -88.01% mean?
Atrium Therapeutics (RNA) has a Operating Margin % of -88.01% as of Mar. 2026. Operating margin is the ratio of total operating income to net sales. View historical data on Atrium Therapeutics and its competitors. According to the industry distribution chart, Atrium Therapeutics ranks #613 out of 945 companies in the Biotechnology industry, placing it in the top 64.9%.
Is Atrium Therapeutics' Operating Margin % too high?
Atrium Therapeutics' current Operating Margin % is -88.01%. Based on the distribution chart, Atrium Therapeutics ranks #613 out of 945 companies in the Biotechnology industry, which is below the industry midpoint. Overall, Atrium Therapeutics has a GF Score™ of 12/100, reflecting its overall financial health beyond just this single metric.
How does Atrium Therapeutics' Operating Margin % compare to RNAC and KROS?
According to the Biotechnology industry distribution chart, Atrium Therapeutics ranks #613 out of 945 companies for Operating Margin %. This places Atrium Therapeutics in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Operating Margin % for a Biotechnology company?
A good Operating Margin % depends on the Biotechnology industry context. However, Operating Margin % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Operating Margin % mean?
A high Operating Margin % can signal that a stock is expensive relative to its fundamentals. Operating margin is the ratio of total operating income to net sales. View historical data on Atrium Therapeutics and its competitors. Atrium Therapeutics's current Operating Margin % is -88.01%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Atrium Therapeutics stock overvalued right now?
Atrium Therapeutics (RNA) has a current Operating Margin % of -88.01%. The current Operating Margin % is -88.01%. Atrium Therapeutics' overall GF Score™ is 12/100 with 1 warning sign to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Operating Margin % calculated?
Operating Margin % is calculated from a company's financial statements. For Atrium Therapeutics (RNA), the current Operating Margin % is -88.01% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Atrium Therapeutics Business Description

Address 10578 Science Center Drive, Suite 125, San Diego, CA, USA, 92121
Atrium Therapeutics Inc is a biopharmaceutical firm focused on developing RNA-based therapeutics for cardiac conditions, including cardiomyopathies. Its platform technology is designed to enable targeted delivery of RNA therapeutics to heart tissue by combining ligand-based targeting approaches with oligonucleotide-based therapies. The company's development pipeline includes programs targeting genetically associated forms of cardiomyopathy, specifically involving the PRKAG2 and PLN genes.
12GF Score

Get the complete analysis for RNA

Operating Margin % is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

$12.80
Price