CytomX TherapeuticsCTMX -1.51%36 PB Ratio is 2.23 as of Jun. 25, 2026, which is 55% below its 10-year median of 5.01. GuruFocus rates CTMX with a GF Score™ of 36/100 and a GF Value™ of $0.28 (Significantly Overvalued). The stock has 4 warning signs investors should review. Among 1,233 Biotechnology companies, CytomX Therapeutics ranks better than 58.39% on this metric.
The historical rank and industry rank for CytomX Therapeutics's PB Ratio or its related term are showing as below:
CTMX'
s PB Ratio Range Over the Past 10 Years
Min: 1.46 Med: 5.01 Max: 24.4
Current: 2.22
During the past 13 years, CytomX Therapeutics's highest PB Ratio was 24.40. The lowest was 1.46. And the median was 5.01.
CTMX's PB Ratio is ranked better than 58.39% of 1233
companies
in the Biotechnology industry
Industry Median: 2.8
vs CTMX: 2.22
During the past 12 months, CytomX Therapeutics's average Book Value Per Share Growth Rate was 372.70% per year.
During the past 13 years, the highest 3-Year average Book Value Per Share Growth Rate of CytomX Therapeutics was 5.00% per year. The lowest was -63.60% per year. And the median was -12.75% per year.
Back to Basics: PB Ratio
CytomX Therapeutics (NAS:CTMX) PB Ratio Explanation
The PB Ratio works the best for the businesses that earn most of their profit from their assets, e.g. banks and insurance companies.
Be Aware
Some businesses have very light assets, such as software companies or insurance agencies. The PB Ratio does not work well for these companies. Some companies even have negative equity, so the PB Ratio cannot be applied to them.
CytomX Therapeutics PB Ratio Related Terms
CytomX Therapeutics PB Ratio Historical Data
* Premium members only.
The historical data trend for CytomX Therapeutics's PB Ratio can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
For the Biotechnology subindustry, CytomX Therapeutics's PB Ratio, along with its competitors' market caps and PB Ratio data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
CytomX Therapeutics PB Ratio vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, CytomX Therapeutics's PB Ratio distribution charts can be found below:
* The bar in red indicates where CytomX Therapeutics's PB Ratio falls into.
The PB Ratio, or Price-to-Book ratio, or Price/Book, is a financial ratio used to compare a company's market price to its Book Value per Share. It is a ratio widely used to value stocks.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
It can also be calculated from the numbers for the whole company:
A closely related ratio is called Price-to-Tangible-Book. The difference between Price-to-Tangible-Book and PB Ratio is that book value other than intangibles are used in the calculation.
CytomX Therapeutics (CTMX) has a PB Ratio of 2.23 as of Jun. 25, 2026. Price-to-Book ratio is the ratio of share price to a company's book value per share. View historical data on CytomX Therapeutics and its competitors. This is 55% below median its historical median of 5.01. Over the past decade, CytomX Therapeutics' PB Ratio has ranged from 1.46 to 24.40. According to the industry distribution chart, CytomX Therapeutics ranks #513 out of 1233 companies in the Biotechnology industry, placing it in the top 41.6%.
Is CytomX Therapeutics' PB Ratio too high?
CytomX Therapeutics' current PB Ratio of 2.23 is 55% below median its 10-year median of 5.01. Over the past 10 years, this metric has ranged from a low of 1.46 to a high of 24.40. The Biotechnology industry median PB Ratio is 2.80. CytomX Therapeutics' value of 2.23 is 20.4% below this industry median. Based on the distribution chart, CytomX Therapeutics ranks #513 out of 1233 companies in the Biotechnology industry, which is above the industry midpoint. Overall, CytomX Therapeutics has a GF Score™ of 36/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does CytomX Therapeutics' PB Ratio compare to SMNR and AURA?
According to the Biotechnology industry distribution chart, CytomX Therapeutics ranks #513 out of 1233 companies for PB Ratio. This puts CytomX Therapeutics in the upper half of its industry. The industry median PB Ratio is 2.80. CytomX Therapeutics' value of 2.23 is 20.4% below this benchmark. Historically, CytomX Therapeutics' own PB Ratio has ranged from 1.46 to 24.40 over the past decade. While the company's 10-year median is 5.01 vs. the industry median of 2.80, CytomX Therapeutics has consistently been below the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good PB Ratio for a Biotechnology company?
The median PB Ratio among Biotechnology companies is 2.80, based on 1,233 companies in the industry. Companies in the top quartile (top 25%) have a PB Ratio significantly above this median, while those in the bottom quartile fall well below. However, PB Ratio should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. CytomX Therapeutics's current PB Ratio of 2.23 is 20.4% below the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high PB Ratio mean?
A high PB Ratio can signal that a stock is expensive relative to its fundamentals. Price-to-Book ratio is the ratio of share price to a company's book value per share. View historical data on CytomX Therapeutics and its competitors. For the Biotechnology industry, the median PB Ratio is 2.80 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. CytomX Therapeutics's current PB Ratio is 2.23, which is 55% below median its own 10-year median of 5.01. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is CytomX Therapeutics stock overvalued right now?
Based on GuruFocus' analysis, CytomX Therapeutics (CTMX) is currently considered Significantly Overvalued. The stock's GF Value™ is $0.28, compared to a current price of $3.28 — trading 1071.4% above its estimated fair value. The current PB Ratio is 2.23, which is 55% below median its 10-year median of 5.01 and 20.4% below the Biotechnology industry median of 2.80. CytomX Therapeutics' overall GF Score™ is 36/100 with 4 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is PB Ratio calculated?
PB Ratio is calculated from a company's financial statements. For CytomX Therapeutics (CTMX), the current PB Ratio is 2.23 as of Jun. 25, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is CytomX Therapeutics (CTMX) Overvalued in 2026?
Based on GuruFocus' analysis, CytomX Therapeutics stock appears to be overvalued.
The current stock price of $3.28 is trading 1071.4% above its estimated GF Value™ of $0.28.
GuruFocus considers CytomX Therapeutics to be Significantly Overvalued.
Key valuation signals for CTMX:
PB Ratio: 2.23 (55% below median its 10-year median of 5.01)
GF Value™: $0.28 vs. price of $3.28 (1071.4% above fair value)
Industry Position: 20.4% below the Biotechnology median (#513 of 1233)
No single metric tells the full story. See the CTMX stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
CytomX Therapeutics Inc a clinical-stage, oncology-focused biopharmaceutical company developing novel, masked, conditionally activated biologics designed to be localized to the tumor microenvironment. It is engaged in developing antibody therapeutics based on probody technology platforms. The company's probody technology platform creates proprietary cancer immunotherapies against clinically-validated targets and develops cancer therapeutics. Probody therapeutics are designed to take advantage of conditions in the tumor microenvironment to enhance the tumor-targeting features of an antibody and reduce drug activity in healthy tissues.
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