PYXS (Pyxis Oncology) ROC (Joel Greenblatt) %: -510.92% (As of Mar. 2026)

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PYXS Pyxis Oncology Inc PYXS
26 GF Score
Price $3.18
! 4 Warning Signs
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What is Pyxis Oncology ROC (Joel Greenblatt) %?

Pyxis Oncology PYXS +13.17% 26 ROC (Joel Greenblatt) % is -510.92% as of Mar. 2026. GuruFocus rates PYXS with a GF Score™ of 26/100. The stock has 4 warning signs investors should review. Among 1,324 Biotechnology companies, Pyxis Oncology ranks worse than 55.14% on this metric.

Joel Greenblatt defined Return on Capital differently in his book The Little Book That Still Beats the Market (Little Books. Big Profits). He defines ROC (Joel Greenblatt) % as EBIT divided by the total of Property, Plant and Equipment and net working capital. Pyxis Oncology's annualized ROC (Joel Greenblatt) % for the quarter that ended in Mar. 2026 was -510.92%.

The historical rank and industry rank for Pyxis Oncology's ROC (Joel Greenblatt) % or its related term are showing as below:

PYXS' s ROC (Joel Greenblatt) % Range Over the Past 10 Years
Min: -4387.48   Med: -949.63   Max: -291.75
Current: -427.35

During the past 7 years, Pyxis Oncology's highest ROC (Joel Greenblatt) % was -291.75%. The lowest was -4387.48%. And the median was -949.63%.

PYXS's ROC (Joel Greenblatt) % is ranked worse than
55.14% of 1324 companies
in the Biotechnology industry
Industry Median: -305.105 vs PYXS: -427.35

Pyxis Oncology's 5-Year average Growth Rate of ROC (Joel Greenblatt) % was 34.70% per year.


Pyxis Oncology  (NAS:PYXS) ROC (Joel Greenblatt) % Explanation

The way Joel Greenblatt defines Return on Capital is a more accurate measure of how efficiently the company generates returns onthe capital actually invested in the business. EBIT is used instead of net income because the tax and interest payment may be affected by factors other than the core business operation. Intangible assets are not included in the calculation because they don't need to be replaced.

Joel Greenblatt uses his definition of Return on Capital and Earnings Yield (Joel Greenblatt) % to rank companies.


Pyxis Oncology ROC (Joel Greenblatt) % Related Terms


Pyxis Oncology ROC (Joel Greenblatt) % Historical Data

* Premium members only.

The historical data trend for Pyxis Oncology's ROC (Joel Greenblatt) % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Pyxis Oncology ROC (Joel Greenblatt) % Chart

Pyxis Oncology Annual Data
Trend Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
ROC (Joel Greenblatt) %
Get a 7-Day Free Trial -4,387.48 -949.63 -331.56 -291.75 -406.30

Pyxis Oncology Quarterly Data
Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
ROC (Joel Greenblatt) % Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -420.51 -374.20 -459.25 -370.42 -510.92

PYXS vs ORMP, CAMP, ALEC: ROC (Joel Greenblatt) % Comparison

For the Biotechnology subindustry, Pyxis Oncology's ROC (Joel Greenblatt) %, along with its competitors' market caps and ROC (Joel Greenblatt) % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Pyxis Oncology ROC (Joel Greenblatt) % vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Pyxis Oncology's ROC (Joel Greenblatt) % distribution charts can be found below:

* The bar in red indicates where Pyxis Oncology's ROC (Joel Greenblatt) % falls into.


PYXS
26GF Score
Pyxis Oncology Inc PYXS
ROC (Joel Greenblatt) % is just one metric. See GF Score™, valuation, warning signs, and more.
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Pyxis Oncology ROC (Joel Greenblatt) % Calculation

Joel Greenblatt defined Return on Capital differently in his book The Little Book That Still Beats the Market (Little Books. Big Profits) . He defines Return on Capital as follows:

ROC (Joel Greenblatt) %=EBIT/Average of (Net fixed Assets + Net Working Capital)

EBIT stands for Earnings Before Interest and Taxes.

Fixed Assets are also known as non-current assets. They include the Property, Plant and Equipment that the firm needs in its operation.

GuruFocus calculates net working capital as: (Accounts Receivable + Total Inventories + Other Current Assets) - (Accounts Payable & Accrued Expense + Deferred Revenue + Other Current Liabilities). We're trying to account for OPERATING assets and liabilities (part of daily business) when calculating working capital. Cash and marketable securities are considered NON-OPERATING assets and are not included in calculation. We will also back out all interest bearing debt, short term debt and the portion of long term debt that is due in the current period from the current liabilities. This debt will be considered when computing cost of capital and it would be inappropriate to count it twice.

Working Capital(Q: Dec. 2025 )
=(Accounts Receivable + Total Inventories + Other Current Assets) - (Accounts Payable & Accrued Expense + Defer. Rev. + Other Current Liabilities)
=(0 + 0 + 4.548) - (15.692 + 0 + 3.747)
=-14.891

Working Capital(Q: Mar. 2026 )
=(Accounts Receivable + Total Inventories + Other Current Assets) - (Accounts Payable & Accrued Expense + Defer. Rev. + Other Current Liabilities)
=(0 + 0 + 4.554) - (14.775 + 0 + 0)
=-10.221

When net working capital is negative, 0 is used.

So ROC (Joel Greenblatt) % of Pyxis Oncology for the quarter that ended in Mar. 2026 can be restated as:

ROC (Joel Greenblatt) %(Q: Mar. 2026 )
=EBIT/Average of (Net fixed Assets + Net Working Capital)
=EBIT/Average of (Property, Plant and Equipment+Net Working Capital)
     Q: Dec. 2025  Q: Mar. 2026
=EBIT/( ( (Property, Plant and Equipment + Net Working Capital) + (Property, Plant and Equipment + Net Working Capital) )/ count )
=-97.44/( ( (19.415 + max(-14.891, 0)) + (18.728 + max(-10.221, 0)) )/ 2 )
=-97.44/( ( 19.415 + 18.728 )/ 2 )
=-97.44/19.0715
=-510.92 %

Note: The EBIT data used here is four times the quarterly (Mar. 2026) EBIT data.

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

What does a ROC (Joel Greenblatt) % of -510.92% mean?
Pyxis Oncology (PYXS) has a ROC (Joel Greenblatt) % of -510.92% as of Mar. 2026. Joel Greenblatt's return on capital is the ratio of EBIT to average fixed assets and net working capital. View historical data on Pyxis Oncology and its competitors. According to the industry distribution chart, Pyxis Oncology ranks #730 out of 1324 companies in the Biotechnology industry, placing it in the top 55.1%.
Is Pyxis Oncology's ROC (Joel Greenblatt) % too high?
Pyxis Oncology's current ROC (Joel Greenblatt) % is -510.92%. Based on the distribution chart, Pyxis Oncology ranks #730 out of 1324 companies in the Biotechnology industry, which is below the industry midpoint. Overall, Pyxis Oncology has a GF Score™ of 26/100, reflecting its overall financial health beyond just this single metric.
How does Pyxis Oncology's ROC (Joel Greenblatt) % compare to ORMP and CAMP?
According to the Biotechnology industry distribution chart, Pyxis Oncology ranks #730 out of 1324 companies for ROC (Joel Greenblatt) %. This places Pyxis Oncology in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good ROC (Joel Greenblatt) % for a Biotechnology company?
A good ROC (Joel Greenblatt) % depends on the Biotechnology industry context. However, ROC (Joel Greenblatt) % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high ROC (Joel Greenblatt) % mean?
A high ROC (Joel Greenblatt) % can signal that a stock is expensive relative to its fundamentals. Joel Greenblatt's return on capital is the ratio of EBIT to average fixed assets and net working capital. View historical data on Pyxis Oncology and its competitors. Pyxis Oncology's current ROC (Joel Greenblatt) % is -510.92%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Pyxis Oncology stock overvalued right now?
Pyxis Oncology (PYXS) has a current ROC (Joel Greenblatt) % of -510.92%. The current ROC (Joel Greenblatt) % is -510.92%. Pyxis Oncology's overall GF Score™ is 26/100 with 4 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is ROC (Joel Greenblatt) % calculated?
ROC (Joel Greenblatt) % is calculated from a company's financial statements. For Pyxis Oncology (PYXS), the current ROC (Joel Greenblatt) % is -510.92% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Pyxis Oncology Business Description

Address 321 Harrison Avenue, Boston, MA, USA, 02118
Pyxis Oncology Inc is a clinical-stage oncology company focused on developing therapies for patients with solid tumors, with an initial emphasis on head and neck squamous cell carcinoma. Its product candidate, micvotabart pelidotin (MICVO, formerly PYX-201), is an investigational antibody-drug conjugate that targets extradomain-B fibronectin (EDB+FN), a component of the tumor extracellular matrix that is expressed in tumors and minimally present in normal tissues. MICVO consists of a fully human monoclonal antibody linked to a microtubule inhibitor payload, designed to bind within the tumor microenvironment and release its payload to kill cancer cells directly, affect nearby cells through a bystander effect, and induce immunogenic cell death, supporting enhanced anti-tumor activity.
26GF Score

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ROC (Joel Greenblatt) % is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

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