ALEC (Alector) ROE % Adjusted to Book Value: -19.55% (As of Mar. 2026)

Alector ALEC -1.65% 29 ROE % Adjusted to Book Value is -19.55% as of Mar. 2026. GuruFocus rates ALEC with a GF Score™ of 29/100 and a GF Value™ of $0.73 (Significantly Overvalued). The stock has 7 warning signs investors should review.

Alector's ROE % for the quarter that ended in Mar. 2026 was -447.08%. Alector's PB Ratio for the quarter that ended in Mar. 2026 was 22.87. Alector's ROE % Adjusted to Book Value for the quarter that ended in Mar. 2026 was -19.55%.

Alector ROE % Adjusted to Book Value Related Terms

Alector ROE % Adjusted to Book Value Historical Data

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The historical data trend for Alector's ROE % Adjusted to Book Value can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Alector ROE % Adjusted to Book Value Chart

Alector Annual Data

Trend

Dec16

Dec17

Dec18

Dec19

Dec20

Dec21

Dec22

Dec23

Dec24

Dec25

ROE % Adjusted to Book Value

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-2.27

-14.50

-14.81

-61.65

-32.36

Alector Quarterly Data
	Jun21	Sep21	Dec21	Mar22	Jun22	Sep22	Dec22	Mar23	Jun23	Sep23	Dec23	Mar24	Jun24	Sep24	Dec24	Mar25	Jun25	Sep25	Dec25	Mar26
ROE % Adjusted to Book Value	Get a 7-Day Free Trial															-112.48	-74.02	-39.05	-60.14	-19.55

ALEC vs SLGL, LENZ, CNXU: ROE % Adjusted to Book Value Comparison

For the Biotechnology subindustry, Alector's ROE % Adjusted to Book Value, along with its competitors' market caps and ROE % Adjusted to Book Value data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.

Alector ROE % Adjusted to Book Value vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Alector's ROE % Adjusted to Book Value distribution charts can be found below:

* The bar in red indicates where Alector's ROE % Adjusted to Book Value falls into.

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Alector Inc ALEC

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Alector ROE % Adjusted to Book Value Calculation

Alector's ROE % Adjusted to Book Value for the fiscal year that ended in Dec. 2025 is calculated as

ROE % Adjusted to Book Value	=	ROE %	/	PB Ratio
	=	-181.56%	/	5.61
	=	-32.36%

Alector's ROE % Adjusted to Book Value for the quarter that ended in Mar. 2026 is calculated as

ROE % Adjusted to Book Value	=	ROE %	/	PB Ratio
	=	-447.08%	/	22.87
	=	-19.55%

Frequently Asked Questions Learn more about ROE % Adjusted to Book Value →

What does a ROE % Adjusted to Book Value of -19.55% mean?

Alector (ALEC) has a ROE % Adjusted to Book Value of -19.55% as of Mar. 2026. Return on equity adjusted to book is the ratio of return on equity to price-book ratio. View historical data on Alector and its competitors.

Is Alector's ROE % Adjusted to Book Value too high?

Alector's current ROE % Adjusted to Book Value is -19.55%. Overall, Alector has a GF Score™ of 29/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.

How does Alector's ROE % Adjusted to Book Value compare to SLGL and LENZ?

Alector's ROE % Adjusted to Book Value of -19.55% can be compared against companies in the Biotechnology industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.

What is a good ROE % Adjusted to Book Value for a Biotechnology company?

A good ROE % Adjusted to Book Value depends on the Biotechnology industry context. However, ROE % Adjusted to Book Value should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.

What does a high ROE % Adjusted to Book Value mean?

A high ROE % Adjusted to Book Value can signal that a stock is expensive relative to its fundamentals. Return on equity adjusted to book is the ratio of return on equity to price-book ratio. View historical data on Alector and its competitors. Alector's current ROE % Adjusted to Book Value is -19.55%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.

Is Alector stock overvalued right now?

Based on GuruFocus' analysis, Alector (ALEC) is currently considered Significantly Overvalued. The stock's GF Value™ is $0.73, compared to a current price of $1.80 — trading 146.6% above its estimated fair value. The current ROE % Adjusted to Book Value is -19.55%. Alector's overall GF Score™ is 29/100 with 7 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.

How is ROE % Adjusted to Book Value calculated?

ROE % Adjusted to Book Value is calculated from a company's financial statements. For Alector (ALEC), the current ROE % Adjusted to Book Value is -19.55% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is Alector (ALEC) Overvalued in 2026?

Based on GuruFocus' analysis, Alector stock appears to be overvalued. The current stock price of $1.80 is trading 146.6% above its estimated GF Value™ of $0.73. GuruFocus considers Alector to be Significantly Overvalued.

Key valuation signals for ALEC:

ROE % Adjusted to Book Value: -19.55%
GF Value™: $0.73 vs. price of $1.80 (146.6% above fair value)
GF Score™: 29/100 with 7 warning signs

No single metric tells the full story. See the ALEC stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.

Alector Business Description

Industry Healthcare Biotechnology

Comparable Companies SLGL LENZ CNXU OBIO CRBU VYGR CHRS WHWK NKTX IKT VRTX REGN XBRU:UCB XBRU:ARGX XKRX:207940 ALNY RVMD ASX:CSL ONC XKRX:068270

Address 131 Oyster Point Boulevard, Suite 600, South San Francisco, CA, USA, 94080

Website https://www.alector.com

Alector Inc is a clinical-stage biotechnology company focused on developing therapies for neurodegenerative diseases. The company advances a pipeline of product candidates including Nivisnebart (AL101/GSK4527226) for Alzheimer's disease, AL137 for Alzheimer's disease, AL050 for Parkinson's disease and Lewy body dementia, and AL064, an siRNA program targeting tau for Alzheimer's disease and other tauopathies, supported by its proprietary Alector Brain Carrier (ABC) platform designed to improve delivery of therapeutics across the blood-brain barrier.

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$1.80

Price

$0.73

GF Value

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