PCSA (Processa Pharmaceuticals) ROE %: -332.79% (As of Mar. 2026)


PCSA Processa Pharmaceuticals Inc PCSA
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What is Processa Pharmaceuticals ROE %?

Processa Pharmaceuticals PCSA +9.64% 28 ROE % is -332.79% as of Mar. 2026. GuruFocus rates PCSA with a GF Score™ of 28/100. The stock has 1 warning sign investors should review. Among 1,248 Biotechnology companies, Processa Pharmaceuticals ranks worse than 92.39% on this metric.

ROE % is calculated as Net Income divided by its average Total Stockholders Equity over a certain period of time. Processa Pharmaceuticals's annualized net income for the quarter that ended in Mar. 2026 was $-13.51 Mil. Processa Pharmaceuticals's average Total Stockholders Equity over the quarter that ended in Mar. 2026 was $4.06 Mil. Therefore, Processa Pharmaceuticals's annualized ROE % for the quarter that ended in Mar. 2026 was -332.79%.

The historical rank and industry rank for Processa Pharmaceuticals's ROE % or its related term are showing as below:

PCSA' s ROE % Range Over the Past 10 Years
Min: -373   Med: -129.79   Max: -37.91
Current: -299.05

During the past 13 years, Processa Pharmaceuticals's highest ROE % was -37.91%. The lowest was -373.00%. And the median was -129.79%.

PCSA's ROE % is ranked worse than
92.39% of 1248 companies
in the Biotechnology industry
Industry Median: -38.535 vs PCSA: -299.05

Processa Pharmaceuticals  (NAS:PCSA) ROE % Explanation

ROE % measures the rate of return on the ownership interest (shareholder's equity) of the common stock owners. It measures a firm's efficiency at generating profits from every unit of shareholders' equity (also known as net assets or assets minus liabilities). ROE % shows how well a company uses investment funds to generate earnings growth. ROE %s between 15% and 20% are considered desirable.

The factors that affect a company's ROE % can be illustrated with the three-step DuPont Analysis:

ROE %(Q: Mar. 2026 )
=Net Income/Total Stockholders Equity
=-13.508/4.059
=(Net Income / Revenue )*(Revenue / Total Assets)*(Total Assets / Total Stockholders Equity)
=(-13.508 / 0)*(0 / 6.1675)*(6.1675 / 4.059)
=Net Margin %*Asset Turnover*Equity Multiplier
=N/A %*0*1.5195
=ROA %*Equity Multiplier
=N/A %*1.5195
=-332.79 %

With this breakdown, it is clear that if a company grows its Net Profit Margin, its Asset Turnover, or its Leverage, it can grow its ROE %.

The factors that affect a company's ROE % can also be illustrated with the five-step DuPont Analysis:

ROE %(Q: Mar. 2026 )
=Net Income/Total Stockholders Equity
=-13.508/4.059
=(Net Income / Pre-Tax Income) * (Pre-Tax Income / Operating Income) * (Operating Income / Revenue) * (Revenue / Total Assets) * (Total Assets / Total Stockholders Equity)
= (-13.508 / -13.508) * (-13.508 / -13.324) * (-13.324 / 0) * (0 / 6.1675) * (6.1675 / 4.059)
= Tax Burden * Interest Burden * Operating Margin % * Asset Turnover * Equity Multiplier
= 1 * 1.0138 * N/A % * 0 * 1.5195
=-332.79 %

Note: The net income data used here is four times the quarterly (Mar. 2026) net income data. The Revenue data used here is four times the quarterly (Mar. 2026) revenue data. The same rule applies to Pre-Tax Income and Operating Income.
* In the five-step DuPont Analysis, Operating Income is only available for non-financial companies. Thus, for Insurance companies, we use EBIT as a substitution of Operating Income. For Banks, both Operating Income and EBIT is unavailable. Thus we combined Interest Burden and Operating Margin % into Pretax Margin %, and the DuPont Analysis is divided into four components instead.

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.


Be Aware

Net Income is used.

Because a company can increase its ROE % by having more financial leverage, it is important to watch the equity multiplier when investing in high ROE % companies. Like ROA %, ROE % is calculated with only 12 months data. Fluctuations in company's earnings or business cycles can affect the ratio drastically. It is important to look at the ratio from a long term perspective.

Asset light businesses require very few assets to generate very high earnings. Their ROE %s can be extremely high.


Processa Pharmaceuticals ROE % Related Terms


Processa Pharmaceuticals ROE % Historical Data

* Premium members only.

The historical data trend for Processa Pharmaceuticals's ROE % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Processa Pharmaceuticals ROE % Chart

Processa Pharmaceuticals Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
ROE %
Get a 7-Day Free Trial Premium Member Only Premium Member Only -47.20 -166.43 -178.52 -354.53 -373.00

Processa Pharmaceuticals Quarterly Data
Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
ROE % Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -434.08 -326.68 -230.27 -235.49 -332.79

PCSA vs ELAB, MBIO, DRMA: ROE % Comparison

For the Biotechnology subindustry, Processa Pharmaceuticals's ROE %, along with its competitors' market caps and ROE % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Processa Pharmaceuticals ROE % vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Processa Pharmaceuticals's ROE % distribution charts can be found below:

* The bar in red indicates where Processa Pharmaceuticals's ROE % falls into.


PCSA
28GF Score
Processa Pharmaceuticals Inc PCSA
ROE % is just one metric. See GF Score™, valuation, warning signs, and more.
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Processa Pharmaceuticals ROE % Calculation

Processa Pharmaceuticals's annualized ROE % for the fiscal year that ended in Dec. 2025 is calculated as

ROE %=Net Income (A: Dec. 2025 )/( (Total Stockholders Equity (A: Dec. 2024 )+Total Stockholders Equity (A: Dec. 2025 ))/ count )
=-13.564/( (1.696+5.577)/ 2 )
=-13.564/3.6365
=-373.00 %

Processa Pharmaceuticals's annualized ROE % for the quarter that ended in Mar. 2026 is calculated as

ROE %=Net Income (Q: Mar. 2026 )/( (Total Stockholders Equity (Q: Dec. 2025 )+Total Stockholders Equity (Q: Mar. 2026 ))/ count )
=-13.508/( (5.577+2.541)/ 2 )
=-13.508/4.059
=-332.79 %

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

In the calculation of annual ROE %, the net income of the last fiscal year and the average total shareholder equity over the fiscal year are used. In calculating the quarterly data, the net income data used here is four times the quarterly (Mar. 2026) net income data. ROE % is displayed in the 30-year financial page.

Frequently Asked Questions Learn more about ROE % →
What does a ROE % of -332.79% mean?
Processa Pharmaceuticals (PCSA) has a ROE % of -332.79% as of Mar. 2026. Return on equity is the ratio of current-period net income to average two-period total equity. View historical data on Processa Pharmaceuticals and its competitors. According to the industry distribution chart, Processa Pharmaceuticals ranks #1153 out of 1248 companies in the Biotechnology industry, placing it in the top 92.4%.
Is Processa Pharmaceuticals' ROE % too high?
Processa Pharmaceuticals' current ROE % is -332.79%. Based on the distribution chart, Processa Pharmaceuticals ranks #1153 out of 1248 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, Processa Pharmaceuticals has a GF Score™ of 28/100, reflecting its overall financial health beyond just this single metric.
How does Processa Pharmaceuticals' ROE % compare to ELAB and MBIO?
According to the Biotechnology industry distribution chart, Processa Pharmaceuticals ranks #1153 out of 1248 companies for ROE %. This places Processa Pharmaceuticals in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good ROE % for a Biotechnology company?
A good ROE % depends on the Biotechnology industry context. However, ROE % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high ROE % mean?
A high ROE % can signal that a stock is expensive relative to its fundamentals. Return on equity is the ratio of current-period net income to average two-period total equity. View historical data on Processa Pharmaceuticals and its competitors. Processa Pharmaceuticals's current ROE % is -332.79%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Processa Pharmaceuticals stock overvalued right now?
Processa Pharmaceuticals (PCSA) has a current ROE % of -332.79%. The current ROE % is -332.79%. Processa Pharmaceuticals' overall GF Score™ is 28/100 with 1 warning sign to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is ROE % calculated?
ROE % is calculated from a company's financial statements. For Processa Pharmaceuticals (PCSA), the current ROE % is -332.79% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Processa Pharmaceuticals Business Description

Address 601 21st Street, Suite 300, Vero Beach, FL, USA, 32960
Processa Pharmaceuticals Inc is a clinical-stage biopharmaceutical company focused on utilizing its regulatory science approach in the development of Next Generation Chemotherapy (NGC) oncology drug products. The company's strategic prioritization is to advance its pipeline of NGC proprietary small-molecule oncology drugs. The NGC products are new chemical entities, but the company works by changing the metabolism, distribution, and/or elimination of already FDA-approved cancer drugs or their active metabolites while maintaining the mechanism of how the drug kills cancer cells. The four NGC treatments in its pipeline are PCS6422 (also referred to as NGC-Cap), PCS11T, also referred to as NGC-Iri, is an analog of SN38, and PCS11T, PCS12852, and PCS499.
28GF Score

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