Great Novel Therapeutics Biotech & Medicals (ROCO:7427) ROE %: -19.75% (As of Dec. 2025)


ROCO:7427 Great Novel Therapeutics Biotech & Medicals ROCO:7427
52 GF Score
Price NT$39.65
GF Value NT$25.62
Valuation Significantly Overvalued
! 3 Warning Signs
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What is Great Novel Therapeutics Biotech & Medicals ROE %?

Great Novel Therapeutics Biotech & Medicals ROCO:7427 52 ROE % is -19.75% as of Dec. 2025. GuruFocus rates ROCO:7427 with a GF Score™ of 52/100 and a GF Value™ of NT$25.62 (Significantly Overvalued). The stock has 3 warning signs investors should review. Among 1,250 Biotechnology companies, Great Novel Therapeutics Biotech & Medicals ranks better than 64.32% on this metric.

ROE % is calculated as Net Income divided by its average Total Stockholders Equity over a certain period of time. Great Novel Therapeutics Biotech & Medicals's annualized net income for the quarter that ended in Dec. 2025 was NT$-105.37 Mil. Great Novel Therapeutics Biotech & Medicals's average Total Stockholders Equity over the quarter that ended in Dec. 2025 was NT$533.42 Mil. Therefore, Great Novel Therapeutics Biotech & Medicals's annualized ROE % for the quarter that ended in Dec. 2025 was -19.75%.

The historical rank and industry rank for Great Novel Therapeutics Biotech & Medicals's ROE % or its related term are showing as below:

ROCO:7427' s ROE % Range Over the Past 10 Years
Min: -52.19   Med: -20.7   Max: -13.63
Current: -17.2

During the past 8 years, Great Novel Therapeutics Biotech & Medicals's highest ROE % was -13.63%. The lowest was -52.19%. And the median was -20.70%.

ROCO:7427's ROE % is ranked better than
64.32% of 1250 companies
in the Biotechnology industry
Industry Median: -38.26 vs ROCO:7427: -17.20

Great Novel Therapeutics Biotech & Medicals  (ROCO:7427) ROE % Explanation

ROE % measures the rate of return on the ownership interest (shareholder's equity) of the common stock owners. It measures a firm's efficiency at generating profits from every unit of shareholders' equity (also known as net assets or assets minus liabilities). ROE % shows how well a company uses investment funds to generate earnings growth. ROE %s between 15% and 20% are considered desirable.

The factors that affect a company's ROE % can be illustrated with the three-step DuPont Analysis:

ROE %(Q: Dec. 2025 )
=Net Income/Total Stockholders Equity
=-105.372/533.42
=(Net Income / Revenue )*(Revenue / Total Assets)*(Total Assets / Total Stockholders Equity)
=(-105.372 / 1.164)*(1.164 / 556.9625)*(556.9625 / 533.42)
=Net Margin %*Asset Turnover*Equity Multiplier
=-9052.58 %*0.0021*1.0441
=ROA %*Equity Multiplier
=-19.01 %*1.0441
=-19.75 %

With this breakdown, it is clear that if a company grows its Net Profit Margin, its Asset Turnover, or its Leverage, it can grow its ROE %.

The factors that affect a company's ROE % can also be illustrated with the five-step DuPont Analysis:

ROE %(Q: Dec. 2025 )
=Net Income/Total Stockholders Equity
=-105.372/533.42
=(Net Income / Pre-Tax Income) * (Pre-Tax Income / Operating Income) * (Operating Income / Revenue) * (Revenue / Total Assets) * (Total Assets / Total Stockholders Equity)
= (-105.372 / -105.372) * (-105.372 / -111.336) * (-111.336 / 1.164) * (1.164 / 556.9625) * (556.9625 / 533.42)
= Tax Burden * Interest Burden * Operating Margin % * Asset Turnover * Equity Multiplier
= 1 * 0.9464 * -9564.95 % * 0.0021 * 1.0441
=-19.75 %

Note: The net income data used here is two times the semi-annual (Dec. 2025) net income data. The Revenue data used here is two times the semi-annual (Dec. 2025) revenue data. The same rule applies to Pre-Tax Income and Operating Income.
* In the five-step DuPont Analysis, Operating Income is only available for non-financial companies. Thus, for Insurance companies, we use EBIT as a substitution of Operating Income. For Banks, both Operating Income and EBIT is unavailable. Thus we combined Interest Burden and Operating Margin % into Pretax Margin %, and the DuPont Analysis is divided into four components instead.

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.


Be Aware

Net Income is used.

Because a company can increase its ROE % by having more financial leverage, it is important to watch the equity multiplier when investing in high ROE % companies. Like ROA %, ROE % is calculated with only 12 months data. Fluctuations in company's earnings or business cycles can affect the ratio drastically. It is important to look at the ratio from a long term perspective.

Asset light businesses require very few assets to generate very high earnings. Their ROE %s can be extremely high.


Great Novel Therapeutics Biotech & Medicals ROE % Related Terms


Great Novel Therapeutics Biotech & Medicals ROE % Historical Data

* Premium members only.

The historical data trend for Great Novel Therapeutics Biotech & Medicals's ROE % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Great Novel Therapeutics Biotech & Medicals ROE % Chart

Great Novel Therapeutics Biotech & Medicals Annual Data
Trend Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
ROE %
Get a 7-Day Free Trial -21.80 -19.60 -13.63 -17.97 -17.16

Great Novel Therapeutics Biotech & Medicals Semi-Annual Data
Dec18 Dec19 Jun20 Dec20 Jun21 Dec21 Jun22 Dec22 Jun23 Dec23 Jun24 Dec24 Jun25 Dec25
ROE % Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -8.67 -20.56 -13.18 -14.96 -19.75

ROCO:7427 vs VRTX, REGN, ALNY: ROE % Comparison

For the Biotechnology subindustry, Great Novel Therapeutics Biotech & Medicals's ROE %, along with its competitors' market caps and ROE % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Great Novel Therapeutics Biotech & Medicals ROE % vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Great Novel Therapeutics Biotech & Medicals's ROE % distribution charts can be found below:

* The bar in red indicates where Great Novel Therapeutics Biotech & Medicals's ROE % falls into.


ROCO:7427
52GF Score
Great Novel Therapeutics Biotech & Medicals ROCO:7427
ROE % is just one metric. See GF Score™, valuation, warning signs, and more.
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Great Novel Therapeutics Biotech & Medicals ROE % Calculation

Great Novel Therapeutics Biotech & Medicals's annualized ROE % for the fiscal year that ended in Dec. 2025 is calculated as

ROE %=Net Income (A: Dec. 2025 )/( (Total Stockholders Equity (A: Dec. 2024 )+Total Stockholders Equity (A: Dec. 2025 ))/ count )
=-97.473/( (633.323+502.982)/ 2 )
=-97.473/568.1525
=-17.16 %

Great Novel Therapeutics Biotech & Medicals's annualized ROE % for the quarter that ended in Dec. 2025 is calculated as

ROE %=Net Income (Q: Dec. 2025 )/( (Total Stockholders Equity (Q: Jun. 2025 )+Total Stockholders Equity (Q: Dec. 2025 ))/ count )
=-105.372/( (563.858+502.982)/ 2 )
=-105.372/533.42
=-19.75 %

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

In the calculation of annual ROE %, the net income of the last fiscal year and the average total shareholder equity over the fiscal year are used. In calculating the quarterly data, the net income data used here is two times the semi-annual (Dec. 2025) net income data. ROE % is displayed in the 30-year financial page.

Frequently Asked Questions Learn more about ROE % →
What does a ROE % of -19.75% mean?
Great Novel Therapeutics Biotech & Medicals (ROCO:7427) has a ROE % of -19.75% as of Dec. 2025. Return on equity is the ratio of current-period net income to average two-period total equity. View historical data on Great Novel Therapeutics Biotech & Medicals and its competitors. According to the industry distribution chart, Great Novel Therapeutics Biotech & Medicals ranks #446 out of 1250 companies in the Biotechnology industry, placing it in the top 35.7%.
Is Great Novel Therapeutics Biotech & Medicals' ROE % too high?
Great Novel Therapeutics Biotech & Medicals' current ROE % is -19.75%. Based on the distribution chart, Great Novel Therapeutics Biotech & Medicals ranks #446 out of 1250 companies in the Biotechnology industry, which is above the industry midpoint. Overall, Great Novel Therapeutics Biotech & Medicals has a GF Score™ of 52/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Great Novel Therapeutics Biotech & Medicals' ROE % compare to VRTX and REGN?
According to the Biotechnology industry distribution chart, Great Novel Therapeutics Biotech & Medicals ranks #446 out of 1250 companies for ROE %. This puts Great Novel Therapeutics Biotech & Medicals in the upper half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good ROE % for a Biotechnology company?
A good ROE % depends on the Biotechnology industry context. However, ROE % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high ROE % mean?
A high ROE % can signal that a stock is expensive relative to its fundamentals. Return on equity is the ratio of current-period net income to average two-period total equity. View historical data on Great Novel Therapeutics Biotech & Medicals and its competitors. Great Novel Therapeutics Biotech & Medicals's current ROE % is -19.75%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Great Novel Therapeutics Biotech & Medicals stock overvalued right now?
Based on GuruFocus' analysis, Great Novel Therapeutics Biotech & Medicals (ROCO:7427) is currently considered Significantly Overvalued. The stock's GF Value™ is NT$25.62, compared to a current price of NT$39.65 — trading 54.8% above its estimated fair value. The current ROE % is -19.75%. Great Novel Therapeutics Biotech & Medicals' overall GF Score™ is 52/100 with 3 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is ROE % calculated?
ROE % is calculated from a company's financial statements. For Great Novel Therapeutics Biotech & Medicals (ROCO:7427), the current ROE % is -19.75% as of Dec. 2025. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is Great Novel Therapeutics Biotech & Medicals (ROCO:7427) Overvalued in 2026?

Based on GuruFocus' analysis, Great Novel Therapeutics Biotech & Medicals stock appears to be overvalued. The current stock price of NT$39.65 is trading 54.8% above its estimated GF Value™ of NT$25.62. GuruFocus considers Great Novel Therapeutics Biotech & Medicals to be Significantly Overvalued.

Key valuation signals for ROCO:7427:

  • ROE %: -19.75%
  • GF Value™: NT$25.62 vs. price of NT$39.65 (54.8% above fair value)
  • GF Score™: 52/100 with 3 warning signs

No single metric tells the full story. See the ROCO:7427 stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


Great Novel Therapeutics Biotech & Medicals Business Description

Address No.3, Park Street, Room WR-06, 17th Floor, Nangang District, Taipei, TWN, 11503
Great Novel Therapeutics Biotech & Medicals focuses on drug development to treat advanced cancer. The new drugs ranging from epigenetic modulators, a combination of tumor microenvironment-regulating agents, epigenetic immuno-modulators, to the protein degradation drugs targeting HDACs 1, 2, and 3, are in a developing pipeline. These drugs focus on the field of epigenetics, for the demand of clinical unmet needs in advanced and refractory cancers.
52GF Score

Get the complete analysis for ROCO:7427

ROE % is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

NT$39.65
Price
NT$25.62
GF Value