Actuate TherapeuticsACTU -13.18%14 3-Year ROIIC % is -269.49 as of Dec. 2025. GuruFocus rates ACTU with a GF Score™ of 14/100. Among 1,324 Biotechnology companies, Actuate Therapeutics ranks worse than 82.85% on this metric.
3-Year Return on Invested Incremental Capital (3-Year ROIIC %) measures the change in earnings as a percentage of change in investment over 3-year.
Actuate Therapeutics's 3-Year ROIIC % for the quarter that ended in Dec. 2025 was -269.49%. High ROIIC is generally an indication that your business is capital efficient or has a higher operating leverage.
The industry rank for Actuate Therapeutics's 3-Year ROIIC % or its related term are showing as below:
ACTU's 3-Year ROIIC % is ranked worse than 82.85% of 1324
companies
in the Biotechnology industry
Industry Median: -4.63
vs ACTU: -269.49
Return on Incremental Invested Capital (ROIIC) is an extension of Return on Investment Capital (ROIC). ROIC % tells investors how efficiently that profitability is earned per dollar of company capital. ROIIC narrows the focus even further and shows how profitable each additional unit of capital investment could be. ROIIC % is a more powerful metric than ROIC because it measures how much money the company can generate going forward on future capital investments.
High ROIIC is generally an indication that your business is capital efficient or has a higher operating leverage.
Be Aware
It's important to keep in mind that when tracking ROIIC, the metric is better suited to forecasting the trend of future returns rather than measuring current return on investment.
Actuate Therapeutics 3-Year ROIIC % Related Terms
Actuate Therapeutics 3-Year ROIIC % Historical Data
* Premium members only.
The historical data trend for Actuate Therapeutics's 3-Year ROIIC % can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
ACTU vs RNXT, ESLA, APLM: 3-Year ROIIC % Comparison
For the Biotechnology subindustry, Actuate Therapeutics's 3-Year ROIIC %, along with its competitors' market caps and 3-Year ROIIC % data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Actuate Therapeutics 3-Year ROIIC % vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Actuate Therapeutics's 3-Year ROIIC % distribution charts can be found below:
* The bar in red indicates where Actuate Therapeutics's 3-Year ROIIC % falls into.
Actuate Therapeutics's 3-Year ROIIC % for the quarter that ended in Dec. 2025 is calculated as:
3-Year ROIIC %
=
3-Year Incremental Net Operating Profit After Taxes (NOPAT)**
/
3-Year Incremental Invested Capital**
=
( -22.495 (Dec. 2025) - -20.207 (Dec. 2022) )
/
( 0.981 (Dec. 2025) - 0.132 (Dec. 2022) )
=
-2.288
/
0.849
=
-269.49%***
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
** Annual data of NOPAT and Invested Capital was used to calculate 3-Year ROIIC %.
*** Please be aware that the ROIIC (Return on Invested Capital) calculations are based on company-level data using the primary share class. The calculated data provided is for demonstration purposes and may slightly differ from the results displayed in the title due to potential variations caused by currency exchange rate differences throughout the year.
Actuate Therapeutics (ACTU) has a 3-Year ROIIC % of -269.49 as of Dec. 2025. 3-Year ROIIC % measures the change in earnings as a percentage of change in investment over 3-year. View historical data on Actuate Therapeutics and its competitors. According to the industry distribution chart, Actuate Therapeutics ranks #1097 out of 1324 companies in the Biotechnology industry, placing it in the top 82.9%.
Is Actuate Therapeutics' 3-Year ROIIC % too high?
Actuate Therapeutics' current 3-Year ROIIC % is -269.49. Based on the distribution chart, Actuate Therapeutics ranks #1097 out of 1324 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, Actuate Therapeutics has a GF Score™ of 14/100, reflecting its overall financial health beyond just this single metric.
How does Actuate Therapeutics' 3-Year ROIIC % compare to RNXT and ESLA?
According to the Biotechnology industry distribution chart, Actuate Therapeutics ranks #1097 out of 1324 companies for 3-Year ROIIC %. This places Actuate Therapeutics in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good 3-Year ROIIC % for a Biotechnology company?
A good 3-Year ROIIC % depends on the Biotechnology industry context. However, 3-Year ROIIC % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high 3-Year ROIIC % mean?
A high 3-Year ROIIC % can signal that a stock is expensive relative to its fundamentals. 3-Year ROIIC % measures the change in earnings as a percentage of change in investment over 3-year. View historical data on Actuate Therapeutics and its competitors. Actuate Therapeutics's current 3-Year ROIIC % is -269.49. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Actuate Therapeutics stock overvalued right now?
Actuate Therapeutics (ACTU) has a current 3-Year ROIIC % of -269.49. The current 3-Year ROIIC % is -269.49. Actuate Therapeutics' overall GF Score™ is 14/100. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is 3-Year ROIIC % calculated?
3-Year ROIIC % is calculated from a company's financial statements. For Actuate Therapeutics (ACTU), the current 3-Year ROIIC % is -269.49 as of Dec. 2025. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Actuate Therapeutics Inc is a clinical stage biopharmaceutical company focused on developing therapies for the treatment of high impact, difficult to treat cancers through the inhibition of glycogen synthase kinase-3 (GSK-3). It is developing elraglusib (formerly 9-ING-41), a small molecule that is designed to enter cancer cells and block the function of the enzyme GSK-3B, a master regulator of complex biological signaling cascades, including those mediated by oncogenes, that lead to tumor cell survival, growth, migration, and invasion.
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