Illumina (MEX:ILMN) Shiller PE Ratio: (As of Aug. 26, 2026)

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MEX:ILMN Illumina Inc MEX:ILMN
48 GF Score
Price MXN3,637.34
GF Value MXN2,141.60
Valuation Significantly Overvalued
! 7 Warning Signs
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What is Illumina Shiller PE Ratio?

Shiller PE for Stocks: The True Measure of Stock Valuation


Illumina  (MEX:ILMN) Shiller PE Ratio Explanation

Compared with the regular PE Ratio, which works poorly for cyclical businesses, the Shiller PE Ratio smoothed out the fluctuations of profit margins during business cycles. Therefore it is more accurate in reflecting the valuation of the company.

If a company has consistent business performance, the Shiller PE Ratio should give similar results to regular PE Ratio.

Compared with the PS Ratio, the Shiller PE Ratio makes the comparison between different industries more meaningful.


Be Aware

Shiller PE Ratio assumes that over the long term, businesses and profitability revert to their means. If a company's business model does not work in the future compared with the past, Shiller PE Ratio and PS Ratio will give false valuations.


Illumina Shiller PE Ratio Related Terms


Illumina Shiller PE Ratio Historical Data

* Premium members only.

The historical data trend for Illumina's Shiller PE Ratio can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Illumina Shiller PE Ratio Chart

Illumina Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
Shiller PE Ratio
Get a 7-Day Free Trial Premium Member Only Premium Member Only 89.04 133.12 199.08 0.00 0.00

Illumina Quarterly Data
Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26 Jun26
Shiller PE Ratio Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only 0.00 0.00 0.00 0.00 0.00

MEX:ILMN vs MTD, DGX, LH: Shiller PE Ratio Comparison

For the Diagnostics & Research subindustry, Illumina's Shiller PE Ratio, along with its competitors' market caps and Shiller PE Ratio data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Illumina Shiller PE Ratio vs Medical Diagnostics & Research Industry

For the Medical Diagnostics & Research industry and Healthcare sector, Illumina's Shiller PE Ratio distribution charts can be found below:

* The bar in red indicates where Illumina's Shiller PE Ratio falls into.


MEX:ILMN
48GF Score
Illumina Inc MEX:ILMN
Shiller PE Ratio is just one metric. See GF Score™, valuation, warning signs, and more.
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Illumina Shiller PE Ratio Calculation

For Shiller PE Ratio, the earnings of the past 10 years are inflation-adjusted and averaged. The result is used for P/E calculation. Since it looks at the average over the last 10 years, the Shiller PE Ratio is also called PE10.

The Shiller PE Ratio was first used by professor Robert Shiller to measure the valuation of the overall market. The same calculation is applied here to individual companies.

Illumina's E10 for the quarter that ended in Jun. 2026 is calculated as:

For example, Illumina's adjusted earnings per share data for the three months ended in Jun. 2026 was:

Adj_EPS=Earnings per Share (Diluted)/CPI of Jun. 2026 (Change)*Current CPI (Jun. 2026)
=23.556/333.9520*333.9520
=23.556

Current CPI (Jun. 2026) = 333.9520.

Illumina Quarterly Data

Earnings per Share (Diluted) CPI Adj_EPS
201609 16.822 241.428 23.269
201612 17.318 241.432 23.954
201703 46.696 243.801 63.963
201706 15.726 244.955 21.440
201709 20.144 246.819 27.255
201712 9.034 246.524 12.238
201803 25.616 249.554 34.279
201806 27.706 251.989 36.718
201809 24.878 252.439 32.911
201812 27.685 251.233 36.800
201903 30.455 254.202 40.010
201906 38.226 256.143 49.838
201909 31.192 256.759 40.570
201912 30.365 256.974 39.461
202003 27.434 258.115 35.494
202006 7.386 257.797 9.568
202009 26.730 260.280 34.296
202012 34.811 260.474 44.631
202103 20.441 264.877 25.772
202106 25.082 271.696 30.829
202109 42.769 274.310 52.068
202112 14.565 278.802 17.446
202203 10.951 287.504 12.720
202206 -68.401 296.311 -77.090
202209 -487.990 296.808 -549.059
202212 -17.351 296.797 -19.523
202303 0.360 301.836 0.398
202306 -25.373 305.109 -27.772
202309 -83.088 307.789 -90.151
202312 -18.841 306.746 -20.512
202403 -13.111 312.332 -14.019
202406 -228.635 314.175 -243.027
202409 87.031 315.301 92.179
202412 24.401 315.605 25.819
202503 16.776 319.799 17.518
202506 28.056 322.561 29.047
202509 17.977 324.800 18.484
202512 38.892 324.054 40.080
202603 15.688 330.213 15.866
202606 23.556 333.952 23.556

Add all the adjusted EPS together and divide 10 will get our E10.

Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.

Is Illumina (MEX:ILMN) Overvalued in 2026?

Based on GuruFocus' analysis, Illumina stock appears to be overvalued. The current stock price of MXN3,637.34 is trading 69.8% above its estimated GF Value™ of MXN2,141.60. GuruFocus considers Illumina to be Significantly Overvalued.

Key valuation signals for MEX:ILMN:

  • Shiller PE Ratio:
  • GF Value™: MXN2,141.60 vs. price of MXN3,637.34 (69.8% above fair value)
  • GF Score™: 48/100 with 7 warning signs

No single metric tells the full story. See the MEX:ILMN stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


Illumina Business Description

Address 5200 Illumina Way, San Diego, CA, USA, 92122
Illumina provides tools and services to analyze genetic material with life science and clinical lab applications. The company generates over 90% of its revenue from sequencing instruments, consumables, and services. Illumina's high-throughput technology enables whole genome sequencing in humans and other large organisms. Its lower throughput tools enable applications that require smaller data outputs, such as viral and cancer tumor screening. Illumina also sells microarrays (9% of 2024 sales) that enable lower-cost, focused genetic screening with primarily consumer and agricultural applications.
48GF Score

Get the complete analysis for MEX:ILMN

Shiller PE Ratio is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

MXN3,637.34
Price
MXN2,141.60
GF Value