Illumina (MEX:ILMN) E10: MXN-4.14 (As of Jun. 2026)

Author: Vera Yuan Vera Yuan
Vera Yuan
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Director of Data and Quant Analytics at GuruFocus
Focused on building reliable datasets, financial models, and research tools for value-minded investors. Committed to turning complex data into practical guidance for value-investing and long-term wealth.
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Charlie Tian
Charlie Tian
Founder & CEO of GuruFocus
Dr. Charlie Tian is the founder and CEO of GuruFocus.com, a leading global investment research platform established in 2004. With a Ph.D. in physics, Dr. Tian transitioned from science to finance, applying a data-driven, disciplined approach to value investing.

MEX:ILMN Illumina Inc MEX:ILMN
57 GF Score
Price MXN3,375.00
GF Value MXN2,165.86
Valuation Significantly Overvalued
! 7 Warning Signs
View Full Analysis

What is Illumina E10?

Illumina MEX:ILMN -4.53% 57 E10 is MXN-4.14 as of Jun. 2026. GuruFocus rates MEX:ILMN with a GF Score™ of 57/100 and a GF Value™ of MXN2,165.86 (Significantly Overvalued). The stock has 7 warning signs investors should review.

E10 is a concept invented by Prof. Robert Shiller, who uses E10 for his Shiller P/E calculation. E10 is the average of the inflation adjusted earnings of a company over the past 10 years.

Illumina's adjusted earnings per share data for the three months ended in Jun. 2026 was MXN23.556. Add all the adjusted EPS for the past 10 years together and divide 10 will get our e10, which is MXN-4.14 for the trailing ten years ended in Jun. 2026.

Please click Growth Rate Calculation Example (GuruFocus) to see how GuruFocus calculates Wal-Mart Stores Inc (WMT)'s revenue growth rate. You can apply the same method to get the E10 growth rate using E10 data.

During the past 13 years, the highest 3-Year average E10 Growth Rate of Illumina was 234.70% per year. The lowest was -41.90% per year. And the median was 44.20% per year.

As of today (2026-08-01), Illumina's current stock price is MXN3375.00. Illumina's E10 for the quarter that ended in Jun. 2026 was MXN-4.14. Illumina's Shiller PE Ratio of today is .

During the past 13 years, the highest Shiller PE Ratio of Illumina was 221.74. The lowest was 42.24. And the median was 118.04.


Illumina  (MEX:ILMN) E10 Explanation

If a company grows much fast than inflation, E10 may underestimate the company's earnings power. Shiller PE Ratio can seem to be too high even the actual P/E is low.

For the Shiller P/E, the earnings of the past 10 years are inflation-adjusted and averaged. The result is used for P/E calculation. Since it looks at the average over the last 10 years, the Shiller P/E is also called PE10.

The Shiller P/E was first used by professor Robert Shiller to measure the valuation of the overall market. The same calculation is applied here to individual companies.

During the past 13 years, the highest Shiller P/E Ratio of Illumina was 221.74. The lowest was 42.24. And the median was 118.04.


Be Aware

Shiller PE Ratio works better for cyclical companies. It gives you a better idea on the company's real earnings power.


Illumina E10 Related Terms


Illumina E10 Historical Data

* Premium members only.

The historical data trend for Illumina's E10 can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Illumina E10 Chart

Illumina Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
E10
Get a 7-Day Free Trial Premium Member Only Premium Member Only 86.24 26.98 11.54 -8.13 -5.10

Illumina Quarterly Data
Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26 Jun26
E10 Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -7.03 -7.58 -5.10 -5.02 -4.14

MEX:ILMN vs MTD, DGX, LH: E10 Comparison

For the Diagnostics & Research subindustry, Illumina's Shiller PE Ratio, along with its competitors' market caps and Shiller PE Ratio data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Illumina Shiller PE Ratio vs Medical Diagnostics & Research Industry

For the Medical Diagnostics & Research industry and Healthcare sector, Illumina's Shiller PE Ratio distribution charts can be found below:

* The bar in red indicates where Illumina's Shiller PE Ratio falls into.


MEX:ILMN
57GF Score
Illumina Inc MEX:ILMN
E10 is just one metric. See GF Score™, valuation, warning signs, and more.
View Full Analysis

Illumina E10 Calculation

E10 is a concept invented by Prof. Robert Shiller, who uses E10 for his Shiller P/E calculation. When we calculate the today's Shiller P/E ratio of a stock, we use today's price divided by E10.

What is E10? How do we calculate E10?

E10 is the average of the inflation adjusted earnings of a company over the past 10 years. Let's use an example to explain.

If we want to calculate the E10 of Wal-Mart (WMT) for Dec. 31, 2010, we need to have the inflation data and the earnings from 2001 through 2010.

We adjusted the earnings of 2001 earnings data with the total inflation from 2001 through 2010 to the equivalent earnings in 2010. If the total inflation from 2001 to 2010 is 40%, and Wal-Mart earned $1 a share in 2001, then the 2001's equivalent earnings in 2010 is $1.4 a share. If Wal-Mart earns $1 again in 2002, and the total inflation from 2002 through 2010 is 35%, then the equivalent 2002 earnings in 2010 is $1.35. So on and so forth, you get the equivalent earnings of past 10 years. Then you add them together and divided the sum by 10 to get E10.

Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.

For example, Illumina's adjusted earnings per share data for the three months ended in Jun. 2026 was:

Adj_EPS= Earnings per Share (Diluted) /CPI of Jun. 2026 (Change)*Current CPI (Jun. 2026)
=23.556/333.9520*333.9520
=23.556

Current CPI (Jun. 2026) = 333.9520.

Illumina Quarterly Data

per share eps CPI Adj_EPS
201609 16.822 241.428 23.269
201612 17.318 241.432 23.954
201703 46.696 243.801 63.963
201706 15.726 244.955 21.440
201709 20.144 246.819 27.255
201712 9.034 246.524 12.238
201803 25.616 249.554 34.279
201806 27.706 251.989 36.718
201809 24.878 252.439 32.911
201812 27.685 251.233 36.800
201903 30.455 254.202 40.010
201906 38.226 256.143 49.838
201909 31.192 256.759 40.570
201912 30.365 256.974 39.461
202003 27.434 258.115 35.494
202006 7.386 257.797 9.568
202009 26.730 260.280 34.296
202012 34.811 260.474 44.631
202103 20.441 264.877 25.772
202106 25.082 271.696 30.829
202109 42.769 274.310 52.068
202112 14.565 278.802 17.446
202203 10.951 287.504 12.720
202206 -68.401 296.311 -77.090
202209 -487.990 296.808 -549.059
202212 -17.351 296.797 -19.523
202303 0.360 301.836 0.398
202306 -25.373 305.109 -27.772
202309 -83.088 307.789 -90.151
202312 -18.841 306.746 -20.512
202403 -13.111 312.332 -14.019
202406 -228.635 314.175 -243.027
202409 87.031 315.301 92.179
202412 24.401 315.605 25.819
202503 16.776 319.799 17.518
202506 28.056 322.561 29.047
202509 17.977 324.800 18.484
202512 38.892 324.054 40.080
202603 15.688 330.213 15.866
202606 23.556 333.952 23.556

Add all the adjusted EPS together and divide 10 will get our e10.

Frequently Asked Questions Learn more about E10 →
What does a E10 of MXN-4.14 mean?
Illumina (MEX:ILMN) has a E10 of MXN-4.14 as of Jun. 2026. E10 represents the company's inflation-adjusted earnings per share over a 10-year period. View historical data on Illumina and its competitors.
Is Illumina's E10 too high?
Illumina's current E10 is MXN-4.14. Overall, Illumina has a GF Score™ of 57/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Illumina's E10 compare to MTD and DGX?
Illumina's E10 of MXN-4.14 can be compared against companies in the Medical Diagnostics & Research industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good E10 for a Medical Diagnostics & Research company?
A good E10 depends on the Medical Diagnostics & Research industry context. However, E10 should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high E10 mean?
A high E10 can signal that a stock is expensive relative to its fundamentals. E10 represents the company's inflation-adjusted earnings per share over a 10-year period. View historical data on Illumina and its competitors. Illumina's current E10 is MXN-4.14. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Illumina stock overvalued right now?
Based on GuruFocus' analysis, Illumina (MEX:ILMN) is currently considered Significantly Overvalued. The stock's GF Value™ is MXN2,165.86, compared to a current price of MXN3,375.00 — trading 55.8% above its estimated fair value. The current E10 is MXN-4.14. Illumina's overall GF Score™ is 57/100 with 7 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is E10 calculated?
E10 is calculated from a company's financial statements. For Illumina (MEX:ILMN), the current E10 is MXN-4.14 as of Jun. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is Illumina (MEX:ILMN) Overvalued in 2026?

Based on GuruFocus' analysis, Illumina stock appears to be overvalued. The current stock price of MXN3,375.00 is trading 55.8% above its estimated GF Value™ of MXN2,165.86. GuruFocus considers Illumina to be Significantly Overvalued.

Key valuation signals for MEX:ILMN:

  • E10: MXN-4.14
  • GF Value™: MXN2,165.86 vs. price of MXN3,375.00 (55.8% above fair value)
  • GF Score™: 57/100 with 7 warning signs

No single metric tells the full story. See the MEX:ILMN stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


Illumina Business Description

Address 5200 Illumina Way, San Diego, CA, USA, 92122
Illumina provides tools and services to analyze genetic material with life science and clinical lab applications. The company generates over 90% of its revenue from sequencing instruments, consumables, and services. Illumina's high-throughput technology enables whole genome sequencing in humans and other large organisms. Its lower throughput tools enable applications that require smaller data outputs, such as viral and cancer tumor screening. Illumina also sells microarrays (9% of 2024 sales) that enable lower-cost, focused genetic screening with primarily consumer and agricultural applications.
57GF Score

Get the complete analysis for MEX:ILMN

E10 is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

MXN3,375.00
Price
MXN2,165.86
GF Value