Krystal Biotech (FRA:4KB) Cyclically Adjusted PB Ratio: (As of Aug. 08, 2026)

Author: Vera Yuan Vera Yuan
Vera Yuan
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Director of Data and Quant Analytics at GuruFocus
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Charlie Tian
Charlie Tian
Founder & CEO of GuruFocus
Dr. Charlie Tian is the founder and CEO of GuruFocus.com, a leading global investment research platform established in 2004. With a Ph.D. in physics, Dr. Tian transitioned from science to finance, applying a data-driven, disciplined approach to value investing.

FRA:4KB Krystal Biotech Inc FRA:4KB
55 GF Score
Price €275.50
GF Value €280.97
Valuation Fairly Valued
! 2 Warning Signs
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What is Krystal Biotech Cyclically Adjusted PB Ratio?

Shiller PE for Stocks: The True Measure of Stock Valuation


Krystal Biotech  (FRA:4KB) Cyclically Adjusted PB Ratio Explanation

Compared with the regular PB Ratio, which works poorly for cyclical businesses, the Cyclically Adjusted PB Ratio smoothed out the fluctuations of book value during business cycles. Therefore it is more accurate in reflecting the valuation of the company.

If a company has consistent business performance, the Cyclically Adjusted PB Ratio should give similar results to regular PB Ratio.


Krystal Biotech Cyclically Adjusted PB Ratio Related Terms


Krystal Biotech Cyclically Adjusted PB Ratio Historical Data

* Premium members only.

The historical data trend for Krystal Biotech's Cyclically Adjusted PB Ratio can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Krystal Biotech Cyclically Adjusted PB Ratio Chart

Krystal Biotech Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
Cyclically Adjusted PB Ratio
Get a 7-Day Free Trial Premium Member Only Premium Member Only 0.00 0.00 0.00 0.00 0.00

Krystal Biotech Quarterly Data
Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26 Jun26
Cyclically Adjusted PB Ratio Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only 0.00 0.00 0.00 0.00 16.68

FRA:4KB vs NUVL, HALO, APGE: Cyclically Adjusted PB Ratio Comparison

For the Biotechnology subindustry, Krystal Biotech's Cyclically Adjusted PB Ratio, along with its competitors' market caps and Cyclically Adjusted PB Ratio data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Krystal Biotech Cyclically Adjusted PB Ratio vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Krystal Biotech's Cyclically Adjusted PB Ratio distribution charts can be found below:

* The bar in red indicates where Krystal Biotech's Cyclically Adjusted PB Ratio falls into.


FRA:4KB
55GF Score
Krystal Biotech Inc FRA:4KB
Cyclically Adjusted PB Ratio is just one metric. See GF Score™, valuation, warning signs, and more.
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Krystal Biotech Cyclically Adjusted PB Ratio Calculation

Like the Shiller PE Ratio, the Cyclically Adjusted PB Ratio takes the Book Value per Share from the past 10 years, adjusts it for inflation, and then calculates the average. This average is then used for the P/B calculation. Because it considers this 10-year average, it's often referred to as the CAPB Ratio.

The Shiller PE Ratio was first used by professor Robert Shiller to measure the valuation of the overall market. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio.

Krystal Biotech's Cyclically Adjusted Book per Share for the quarter that ended in Jun. 2026 is calculated as:

For example, Krystal Biotech's adjusted Book Value per Share data for the three months ended in Jun. 2026 was:

Adj_Book=Book Value per Share/CPI of Jun. 2026 (Change)*Current CPI (Jun. 2026)
=38.481/333.9520*333.9520
=38.481

Current CPI (Jun. 2026) = 333.9520.

Krystal Biotech Quarterly Data

Book Value per Share CPI Adj_Book
201609 0.000 241.428 0.000
201612 -0.122 241.432 -0.169
201703 0.000 243.801 0.000
201706 0.348 244.955 0.474
201709 4.114 246.819 5.566
201712 4.056 246.524 5.494
201803 3.729 249.554 4.990
201806 3.743 251.989 4.960
201809 4.082 252.439 5.400
201812 6.898 251.233 9.169
201903 6.708 254.202 8.812
201906 10.356 256.143 13.502
201909 10.893 256.759 14.168
201912 10.523 256.974 13.675
202003 10.335 258.115 13.372
202006 13.985 257.797 18.116
202009 12.998 260.280 16.677
202012 12.179 260.474 15.615
202103 16.292 264.877 20.541
202106 15.645 271.696 19.230
202109 15.604 274.310 18.997
202112 20.839 278.802 24.961
202203 19.766 287.504 22.959
202206 20.612 296.311 23.230
202209 21.244 296.808 23.903
202212 19.135 296.797 21.530
202303 17.726 301.836 19.612
202306 21.549 305.109 23.586
202309 25.122 307.789 27.257
202312 25.286 306.746 27.529
202403 25.775 312.332 27.559
202406 27.146 314.175 28.855
202409 27.755 315.301 29.397
202412 31.388 315.605 33.213
202503 31.517 319.799 32.912
202506 31.190 322.561 32.291
202509 33.448 324.800 34.390
202512 35.678 324.054 36.768
202603 37.516 330.213 37.941
202606 38.481 333.952 38.481

Add all the adjusted book value per share together and divide the count will get our Cyclically Adjusted Book per Share.

Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.

Is Krystal Biotech (FRA:4KB) Overvalued in 2026?

Based on GuruFocus' analysis, Krystal Biotech stock appears to be undervalued. The current stock price of €275.50 is trading 1.9% below its estimated GF Value™ of €280.97. GuruFocus considers Krystal Biotech to be Fairly Valued.

Key valuation signals for FRA:4KB:

  • Cyclically Adjusted PB Ratio:
  • GF Value™: €280.97 vs. price of €275.50 (1.9% below fair value)
  • GF Score™: 55/100 with 2 warning signs

No single metric tells the full story. See the FRA:4KB stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


Krystal Biotech Business Description

Address 2100 Wharton Street, Suite 701, Pittsburgh, PA, USA, 15203
Krystal Biotech Inc is an integrated, commercial-stage biotechnology company focused on the discovery, development, manufacturing, and commercialization of genetic medicines to treat diseases with high unmet medical needs. The company uses its patented HSV-1-based gene therapy platform to create vectors that deliver therapeutic transgenes to target cells. It possesses exclusive rights to develop, manufacture, and commercialize VYJUVEK internationally. The company operates as one operating segment focused on pharmaceutical products and manufactures, markets, and sells VYJUVEK in the United States and markets and sells VYJUVEK in the European Union, and Japan.
55GF Score

Get the complete analysis for FRA:4KB

Cyclically Adjusted PB Ratio is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

€275.50
Price
€280.97
GF Value