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A high Debt-to-EBITDA ratio generally means that a company may spend more time to paying off its debt. According to Joel Tillinghast's BIG MONEY THINKS SMALL: Biases, Blind Spots, and Smarter Investing, a ratio of Debt-to-EBITDA exceeding four is usually considered scary unless tangible assets cover the debt.
The historical rank and industry rank for Krystal Biotech's Debt-to-EBITDA or its related term are showing as below:
FRA:4KB'
s Debt-to-EBITDA Range Over the Past 10 Years
Min: -1.62 Med: -0.11 Max: 0.07
Current: 0.05
During the past 10 years, the highest Debt-to-EBITDA Ratio of Krystal Biotech was 0.07. The lowest was -1.62. And the median was -0.11.
FRA:4KB's Debt-to-EBITDA is ranked better than 89.35% of 291
companies
in the Biotechnology industry
Industry Median: 1.14
vs FRA:4KB: 0.05
A high Debt-to-EBITDA ratio generally means that a company may spend more time to paying off its debt.
According to Joel Tillinghast's BIG MONEY THINKS SMALL: Biases, Blind Spots, and Smarter Investing, a ratio of Debt-to-EBITDA exceeding four is usually considered scary unless tangible assets cover the debt.
Krystal Biotech Debt-to-EBITDA Related Terms
Krystal Biotech Debt-to-EBITDA Historical Data
* Premium members only.
The historical data trend for Krystal Biotech's Debt-to-EBITDA can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
FRA:4KB vs TECH, SMMT, ARWR: Debt-to-EBITDA Comparison
For the Biotechnology subindustry, Krystal Biotech's Debt-to-EBITDA, along with its competitors' market caps and Debt-to-EBITDA data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Krystal Biotech Debt-to-EBITDA vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Krystal Biotech's Debt-to-EBITDA distribution charts can be found below:
* The bar in red indicates where Krystal Biotech's Debt-to-EBITDA falls into.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
In the calculation of annual Debt-to-EBITDA, the EBITDA of the last fiscal year is used. In calculating the annualized quarterly data,
the EBITDA data used here is four times the quarterly (Mar. 2026) EBITDA data.
Krystal Biotech (FRA:4KB) has a Debt-to-EBITDA of 0.04 as of Mar. 2026. Debt-to-EBITDA ratio represents the ratio of total debt to total earnings before interest, taxes, depreciation and amortization. View historical data on Krystal Biotech. According to the industry distribution chart, Krystal Biotech ranks #31 out of 291 companies in the Biotechnology industry, placing it in the top 10.7%.
Is Krystal Biotech's Debt-to-EBITDA too high?
Krystal Biotech's current Debt-to-EBITDA is 0.04. The Biotechnology industry median Debt-to-EBITDA is 1.14. Krystal Biotech's value of 0.04 is 96.5% below this industry median. Based on the distribution chart, Krystal Biotech ranks #31 out of 291 companies in the Biotechnology industry, which is in the top quartile — a strong position relative to peers. Overall, Krystal Biotech has a GF Score™ of 59/100 and is considered Modestly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Krystal Biotech's Debt-to-EBITDA compare to TECH and SMMT?
According to the Biotechnology industry distribution chart, Krystal Biotech ranks #31 out of 291 companies for Debt-to-EBITDA. This places Krystal Biotech in the top 11% of its industry — outperforming the majority of peers. The industry median Debt-to-EBITDA is 1.14. Krystal Biotech's value of 0.04 is 96.5% below this benchmark. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Debt-to-EBITDA for a Biotechnology company?
The median Debt-to-EBITDA among Biotechnology companies is 1.14, based on 291 companies in the industry. Companies in the top quartile (top 25%) have a Debt-to-EBITDA significantly above this median, while those in the bottom quartile fall well below. However, Debt-to-EBITDA should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Krystal Biotech's current Debt-to-EBITDA of 0.04 is 96.5% below the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Debt-to-EBITDA mean?
A high Debt-to-EBITDA can signal that a stock is expensive relative to its fundamentals. Debt-to-EBITDA ratio represents the ratio of total debt to total earnings before interest, taxes, depreciation and amortization. View historical data on Krystal Biotech. For the Biotechnology industry, the median Debt-to-EBITDA is 1.14 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Krystal Biotech's current Debt-to-EBITDA is 0.04. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Krystal Biotech stock overvalued right now?
Based on GuruFocus' analysis, Krystal Biotech (FRA:4KB) is currently considered Modestly Overvalued. The stock's GF Value™ is €259.92, compared to a current price of €292.50 — trading 12.5% above its estimated fair value. The current Debt-to-EBITDA is 0.04 and 96.5% below the Biotechnology industry median of 1.14. Krystal Biotech's overall GF Score™ is 59/100 with 6 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Debt-to-EBITDA calculated?
Debt-to-EBITDA is calculated from a company's financial statements. For Krystal Biotech (FRA:4KB), the current Debt-to-EBITDA is 0.04 as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is Krystal Biotech (FRA:4KB) Overvalued in 2026?
Based on GuruFocus' analysis, Krystal Biotech stock appears to be overvalued.
The current stock price of €292.50 is trading 12.5% above its estimated GF Value™ of €259.92.
GuruFocus considers Krystal Biotech to be Modestly Overvalued.
Key valuation signals for FRA:4KB:
Debt-to-EBITDA: 0.04
GF Value™: €259.92 vs. price of €292.50 (12.5% above fair value)
Industry Position: 96.5% below the Biotechnology median (#31 of 291)
No single metric tells the full story. See the FRA:4KB stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
Krystal Biotech Inc is an integrated, commercial-stage biotechnology company focused on the discovery, development, manufacturing, and commercialization of genetic medicines to treat diseases with high unmet medical needs. The company uses its patented HSV-1-based gene therapy platform to create vectors that deliver therapeutic transgenes to target cells. It possesses exclusive rights to develop, manufacture, and commercialize VYJUVEK internationally. The company operates as one operating segment focused on pharmaceutical products and manufactures, markets, and sells VYJUVEK in the United States and markets and sells VYJUVEK in the European Union, and Japan.
59GF Score
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Debt-to-EBITDA is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.
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