Krystal Biotech (FRA:4KB) ROE % Adjusted to Book Value: 3.14% (As of Mar. 2026)


FRA:4KB Krystal Biotech Inc FRA:4KB
58 GF Score
Price €313.40
GF Value €262.63
Valuation Modestly Overvalued
! 6 Warning Signs
View Full Analysis

What is Krystal Biotech ROE % Adjusted to Book Value?

Krystal Biotech FRA:4KB +3.23% 58 ROE % Adjusted to Book Value is 3.14% as of Mar. 2026. GuruFocus rates FRA:4KB with a GF Score™ of 58/100 and a GF Value™ of €262.63 (Modestly Overvalued). The stock has 6 warning signs investors should review.

Krystal Biotech's ROE % for the quarter that ended in Mar. 2026 was 18.04%. Krystal Biotech's PB Ratio for the quarter that ended in Mar. 2026 was 5.74. Krystal Biotech's ROE % Adjusted to Book Value for the quarter that ended in Mar. 2026 was 3.14%.


Krystal Biotech ROE % Adjusted to Book Value Related Terms


Krystal Biotech ROE % Adjusted to Book Value Historical Data

* Premium members only.

The historical data trend for Krystal Biotech's ROE % Adjusted to Book Value can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Krystal Biotech ROE % Adjusted to Book Value Chart

Krystal Biotech Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
ROE % Adjusted to Book Value
Get a 7-Day Free Trial Premium Member Only Premium Member Only -5.40 -6.76 0.36 2.18 3.00

Krystal Biotech Quarterly Data
Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
ROE % Adjusted to Book Value Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only 2.72 3.87 6.51 2.91 3.14

FRA:4KB vs NUVL, PRAX, TECH: ROE % Adjusted to Book Value Comparison

For the Biotechnology subindustry, Krystal Biotech's ROE % Adjusted to Book Value, along with its competitors' market caps and ROE % Adjusted to Book Value data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Krystal Biotech ROE % Adjusted to Book Value vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Krystal Biotech's ROE % Adjusted to Book Value distribution charts can be found below:

* The bar in red indicates where Krystal Biotech's ROE % Adjusted to Book Value falls into.


FRA:4KB
58GF Score
Krystal Biotech Inc FRA:4KB
ROE % Adjusted to Book Value is just one metric. See GF Score™, valuation, warning signs, and more.
View Full Analysis

Krystal Biotech ROE % Adjusted to Book Value Calculation

Krystal Biotech's ROE % Adjusted to Book Value for the fiscal year that ended in Dec. 2025 is calculated as

ROE % Adjusted to Book Value=ROE % / PB Ratio
=17.98% / 6.00
=3.00%

Krystal Biotech's ROE % Adjusted to Book Value for the quarter that ended in Mar. 2026 is calculated as

ROE % Adjusted to Book Value=ROE % / PB Ratio
=18.04% / 5.74
=3.14%

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

What does a ROE % Adjusted to Book Value of 3.14% mean?
Krystal Biotech (FRA:4KB) has a ROE % Adjusted to Book Value of 3.14% as of Mar. 2026. Return on equity adjusted to book is the ratio of return on equity to price-book ratio. View historical data on Krystal Biotech and its competitors.
Is Krystal Biotech's ROE % Adjusted to Book Value too high?
Krystal Biotech's current ROE % Adjusted to Book Value is 3.14%. Overall, Krystal Biotech has a GF Score™ of 58/100 and is considered Modestly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Krystal Biotech's ROE % Adjusted to Book Value compare to NUVL and PRAX?
Krystal Biotech's ROE % Adjusted to Book Value of 3.14% can be compared against companies in the Biotechnology industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good ROE % Adjusted to Book Value for a Biotechnology company?
A good ROE % Adjusted to Book Value depends on the Biotechnology industry context. However, ROE % Adjusted to Book Value should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high ROE % Adjusted to Book Value mean?
A high ROE % Adjusted to Book Value can signal that a stock is expensive relative to its fundamentals. Return on equity adjusted to book is the ratio of return on equity to price-book ratio. View historical data on Krystal Biotech and its competitors. Krystal Biotech's current ROE % Adjusted to Book Value is 3.14%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Krystal Biotech stock overvalued right now?
Based on GuruFocus' analysis, Krystal Biotech (FRA:4KB) is currently considered Modestly Overvalued. The stock's GF Value™ is €262.63, compared to a current price of €313.40 — trading 19.3% above its estimated fair value. The current ROE % Adjusted to Book Value is 3.14%. Krystal Biotech's overall GF Score™ is 58/100 with 6 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is ROE % Adjusted to Book Value calculated?
ROE % Adjusted to Book Value is calculated from a company's financial statements. For Krystal Biotech (FRA:4KB), the current ROE % Adjusted to Book Value is 3.14% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is Krystal Biotech (FRA:4KB) Overvalued in 2026?

Based on GuruFocus' analysis, Krystal Biotech stock appears to be overvalued. The current stock price of €313.40 is trading 19.3% above its estimated GF Value™ of €262.63. GuruFocus considers Krystal Biotech to be Modestly Overvalued.

Key valuation signals for FRA:4KB:

  • ROE % Adjusted to Book Value: 3.14%
  • GF Value™: €262.63 vs. price of €313.40 (19.3% above fair value)
  • GF Score™: 58/100 with 6 warning signs

No single metric tells the full story. See the FRA:4KB stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


Krystal Biotech Business Description

Address 2100 Wharton Street, Suite 701, Pittsburgh, PA, USA, 15203
Krystal Biotech Inc is an integrated, commercial-stage biotechnology company focused on the discovery, development, manufacturing, and commercialization of genetic medicines to treat diseases with high unmet medical needs. The company uses its patented HSV-1-based gene therapy platform to create vectors that deliver therapeutic transgenes to target cells. It possesses exclusive rights to develop, manufacture, and commercialize VYJUVEK internationally. The company operates as one operating segment focused on pharmaceutical products and manufactures, markets, and sells VYJUVEK in the United States and markets and sells VYJUVEK in the European Union, and Japan.
58GF Score

Get the complete analysis for FRA:4KB

ROE % Adjusted to Book Value is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

€313.40
Price
€262.63
GF Value