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Epigenomics AGFRA:ECX -0.53%18 Cyclically Adjusted PB Ratio is 0.02 as of Jul. 18, 2026, which is 99% below its 10-year median of 2.53. GuruFocus rates FRA:ECX with a GF Score™ of 18/100 and a GF Value™ of €0.09 (Significantly Overvalued). The stock has 3 warning signs investors should review. Among 136 Medical Diagnostics & Research companies, Epigenomics AG ranks better than 97.79% on this metric.
The historical rank and industry rank for Epigenomics AG's Cyclically Adjusted PB Ratio or its related term are showing as below:
FRA:ECX'
s Cyclically Adjusted PB Ratio Range Over the Past 10 Years
Min: 0.02 Med: 2.53 Max: 11.29
Current: 0.02
During the past 13 years, Epigenomics AG's highest Cyclically Adjusted PB Ratio was 11.29. The lowest was 0.02. And the median was 2.53.
FRA:ECX's Cyclically Adjusted PB Ratio is ranked better than 97.79% of 136
companies
in the Medical Diagnostics & Research industry
Industry Median: 1.915
vs FRA:ECX: 0.02
The Shiller PE Ratio was first used by professor Robert Shiller. He uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings per share of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio. The Cyclically Adjusted Book per Share is the average of the inflation adjusted book value per share of a company over the past 10 years.
Epigenomics AG's adjusted book value per share data of for the fiscal year that ended in Dec25 was €0.002. Add all the adjusted book value per share for the past 10 years together and divide the count will get our Cyclically Adjusted Book per Share, which is €54.14 for the trailing ten years ended in Dec25.
Shiller PE for Stocks: The True Measure of Stock Valuation
Epigenomics AG (FRA:ECX) Cyclically Adjusted PB Ratio Explanation
Compared with the regular PB Ratio, which works poorly for cyclical businesses, the Cyclically Adjusted PB Ratio smoothed out the fluctuations of book value during business cycles. Therefore it is more accurate in reflecting the valuation of the company.
If a company has consistent business performance, the Cyclically Adjusted PB Ratio should give similar results to regular PB Ratio.
Epigenomics AG Cyclically Adjusted PB Ratio Related Terms
Epigenomics AG Cyclically Adjusted PB Ratio Historical Data
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The historical data trend for Epigenomics AG's Cyclically Adjusted PB Ratio can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
FRA:ECX vs TMO, DHR, IDXX: Cyclically Adjusted PB Ratio Comparison
For the Diagnostics & Research subindustry, Epigenomics AG's Cyclically Adjusted PB Ratio, along with its competitors' market caps and Cyclically Adjusted PB Ratio data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Epigenomics AG Cyclically Adjusted PB Ratio vs Medical Diagnostics & Research Industry
For the Medical Diagnostics & Research industry and Healthcare sector, Epigenomics AG's Cyclically Adjusted PB Ratio distribution charts can be found below:
* The bar in red indicates where Epigenomics AG's Cyclically Adjusted PB Ratio falls into.
Epigenomics AG Cyclically Adjusted PB Ratio Calculation
Like the Shiller PE Ratio, the Cyclically Adjusted PB Ratio takes the Book Value per Share from the past 10 years, adjusts it for inflation, and then calculates the average. This average is then used for the P/B calculation. Because it considers this 10-year average, it's often referred to as the CAPB Ratio.
The Shiller PE Ratio was first used by professor Robert Shiller to measure the valuation of the overall market. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio.
Epigenomics AG's Cyclically Adjusted PB Ratio for today is calculated as
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.
What does a Cyclically Adjusted PB Ratio of 0.02 mean?
Epigenomics AG (FRA:ECX) has a Cyclically Adjusted PB Ratio of 0.02 as of Jul. 18, 2026. Cyclically Adjusted PB Ratio is the ratio of share price to a company's inflation-adjusted book value per share over a 10-year period. View historical data on Epigenomics AG and its competitors. This is 99% below median its historical median of 2.53. Over the past decade, Epigenomics AG's Cyclically Adjusted PB Ratio has ranged from 0.02 to 11.29. According to the industry distribution chart, Epigenomics AG ranks #3 out of 136 companies in the Medical Diagnostics & Research industry, placing it in the top 2.2%.
Is Epigenomics AG's Cyclically Adjusted PB Ratio too high?
Epigenomics AG's current Cyclically Adjusted PB Ratio of 0.02 is 99% below median its 10-year median of 2.53. Over the past 10 years, this metric has ranged from a low of 0.02 to a high of 11.29. The Medical Diagnostics & Research industry median Cyclically Adjusted PB Ratio is 1.92. Epigenomics AG's value of 0.02 is 99% below this industry median. Based on the distribution chart, Epigenomics AG ranks #3 out of 136 companies in the Medical Diagnostics & Research industry, which is in the top quartile — a strong position relative to peers. Overall, Epigenomics AG has a GF Score™ of 18/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Epigenomics AG's Cyclically Adjusted PB Ratio compare to TMO and DHR?
According to the Medical Diagnostics & Research industry distribution chart, Epigenomics AG ranks #3 out of 136 companies for Cyclically Adjusted PB Ratio. This places Epigenomics AG in the top 2% of its industry — outperforming the majority of peers. The industry median Cyclically Adjusted PB Ratio is 1.92. Epigenomics AG's value of 0.02 is 99% below this benchmark. Historically, Epigenomics AG's own Cyclically Adjusted PB Ratio has ranged from 0.02 to 11.29 over the past decade. While the company's 10-year median is 2.53 vs. the industry median of 1.92, Epigenomics AG has consistently been below the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Cyclically Adjusted PB Ratio for a Medical Diagnostics & Research company?
The median Cyclically Adjusted PB Ratio among Medical Diagnostics & Research companies is 1.92, based on 136 companies in the industry. Companies in the top quartile (top 25%) have a Cyclically Adjusted PB Ratio significantly above this median, while those in the bottom quartile fall well below. However, Cyclically Adjusted PB Ratio should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Epigenomics AG's current Cyclically Adjusted PB Ratio of 0.02 is 99% below the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Cyclically Adjusted PB Ratio mean?
A high Cyclically Adjusted PB Ratio can signal that a stock is expensive relative to its fundamentals. Cyclically Adjusted PB Ratio is the ratio of share price to a company's inflation-adjusted book value per share over a 10-year period. View historical data on Epigenomics AG and its competitors. For the Medical Diagnostics & Research industry, the median Cyclically Adjusted PB Ratio is 1.92 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Epigenomics AG's current Cyclically Adjusted PB Ratio is 0.02, which is 99% below median its own 10-year median of 2.53. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Epigenomics AG stock overvalued right now?
Based on GuruFocus' analysis, Epigenomics AG (FRA:ECX) is currently considered Significantly Overvalued. The stock's GF Value™ is €0.09, compared to a current price of €0.94 — trading 944.4% above its estimated fair value. The current Cyclically Adjusted PB Ratio is 0.02, which is 99% below median its 10-year median of 2.53 and 99% below the Medical Diagnostics & Research industry median of 1.92. Epigenomics AG's overall GF Score™ is 18/100 with 3 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Cyclically Adjusted PB Ratio calculated?
Cyclically Adjusted PB Ratio is calculated from a company's financial statements. For Epigenomics AG (FRA:ECX), the current Cyclically Adjusted PB Ratio is 0.02 as of Jul. 18, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is Epigenomics AG (FRA:ECX) Overvalued in 2026?
Based on GuruFocus' analysis, Epigenomics AG stock appears to be overvalued.
The current stock price of €0.94 is trading 944.4% above its estimated GF Value™ of €0.09.
GuruFocus considers Epigenomics AG to be Significantly Overvalued.
Key valuation signals for FRA:ECX:
Cyclically Adjusted PB Ratio: 0.02 (99% below median its 10-year median of 2.53)
GF Value™: €0.09 vs. price of €0.94 (944.4% above fair value)
Industry Position: 99% below the Medical Diagnostics & Research median (#3 of 136)
No single metric tells the full story. See the FRA:ECX stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
Epigenomics AG is a molecular diagnostics company, that focuses on developing and commercializing in vitro diagnostic liquid biopsy tests for the screening, early detection, and diagnosis of cancer. The company develops and markets procedures and devices for the production in quantity of particular epigenetic parameters such as DNA methylation patterns as well as the information technology bases necessary for their procurement and evaluation. It is engaged in the development of novel molecular diagnostic products for cancer. The company products include Epi proColon, Epi BiSKit, HCCBloodTest, and Epi proLung. The company operates in Europe, Asia, and North America, majority of its revenue derives from Asia.
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