Epigenomics AG (FRA:ECX) ROE %: -22,000.00% (As of Dec. 2025)


FRA:ECX Epigenomics AG FRA:ECX
13 GF Score
Price €0.87
GF Value €0.09
Valuation Significantly Overvalued
! 3 Warning Signs
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What is Epigenomics AG ROE %?

Epigenomics AG FRA:ECX 13 ROE % is -22,000.00% as of Dec. 2025. GuruFocus rates FRA:ECX with a GF Score™ of 13/100 and a GF Value™ of €0.09 (Significantly Overvalued). The stock has 3 warning signs investors should review. Among 202 Medical Diagnostics & Research companies, Epigenomics AG ranks worse than 100% on this metric.

ROE % is calculated as Net Income divided by its average Total Stockholders Equity over a certain period of time. Epigenomics AG's annualized net income for the quarter that ended in Dec. 2025 was €-0.22 Mil. Epigenomics AG's average Total Stockholders Equity over the quarter that ended in Dec. 2025 was €0.00 Mil. Therefore, Epigenomics AG's annualized ROE % for the quarter that ended in Dec. 2025 was -22,000.00%.

The historical rank and industry rank for Epigenomics AG's ROE % or its related term are showing as below:

FRA:ECX' s ROE % Range Over the Past 10 Years
Min: -47100   Med: -95.34   Max: -18.69
Current: -47100

During the past 13 years, Epigenomics AG's highest ROE % was -18.69%. The lowest was -47,100.00%. And the median was -95.34%.

FRA:ECX's ROE % is ranked worse than
100% of 202 companies
in the Medical Diagnostics & Research industry
Industry Median: -1.31 vs FRA:ECX: -47100.00

Epigenomics AG  (FRA:ECX) ROE % Explanation

ROE % measures the rate of return on the ownership interest (shareholder's equity) of the common stock owners. It measures a firm's efficiency at generating profits from every unit of shareholders' equity (also known as net assets or assets minus liabilities). ROE % shows how well a company uses investment funds to generate earnings growth. ROE %s between 15% and 20% are considered desirable.

The factors that affect a company's ROE % can be illustrated with the three-step DuPont Analysis:

ROE %(Q: Dec. 2025 )
=Net Income/Total Stockholders Equity
=-0.22/0.00099999999999289
=(Net Income / Revenue )*(Revenue / Total Assets)*(Total Assets / Total Stockholders Equity)
=(-0.22 / 0.04)*(0.04 / 11.7395)*(11.7395 / 0.00099999999999289)
=Net Margin %*Asset Turnover*Equity Multiplier
=-550 %*0.0034*11739.5
=ROA %*Equity Multiplier
=-1.87 %*11739.5
=-22,000.00 %

With this breakdown, it is clear that if a company grows its Net Profit Margin, its Asset Turnover, or its Leverage, it can grow its ROE %.

The factors that affect a company's ROE % can also be illustrated with the five-step DuPont Analysis:

ROE %(Q: Dec. 2025 )
=Net Income/Total Stockholders Equity
=-0.22/0.00099999999999289
=(Net Income / Pre-Tax Income) * (Pre-Tax Income / Operating Income) * (Operating Income / Revenue) * (Revenue / Total Assets) * (Total Assets / Total Stockholders Equity)
= (-0.22 / -0.22) * (-0.22 / -0.282) * (-0.282 / 0.04) * (0.04 / 11.7395) * (11.7395 / 0.00099999999999289)
= Tax Burden * Interest Burden * Operating Margin % * Asset Turnover * Equity Multiplier
= 1 * 0.7801 * -705 % * 0.0034 * 11739.5
=-22,000.00 %

Note: The net income data used here is two times the semi-annual (Dec. 2025) net income data. The Revenue data used here is two times the semi-annual (Dec. 2025) revenue data. The same rule applies to Pre-Tax Income and Operating Income.
* In the five-step DuPont Analysis, Operating Income is only available for non-financial companies. Thus, for Insurance companies, we use EBIT as a substitution of Operating Income. For Banks, both Operating Income and EBIT is unavailable. Thus we combined Interest Burden and Operating Margin % into Pretax Margin %, and the DuPont Analysis is divided into four components instead.

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.


Be Aware

Net Income is used.

Because a company can increase its ROE % by having more financial leverage, it is important to watch the equity multiplier when investing in high ROE % companies. Like ROA %, ROE % is calculated with only 12 months data. Fluctuations in company's earnings or business cycles can affect the ratio drastically. It is important to look at the ratio from a long term perspective.

Asset light businesses require very few assets to generate very high earnings. Their ROE %s can be extremely high.


Epigenomics AG ROE % Related Terms


Epigenomics AG ROE % Historical Data

* Premium members only.

The historical data trend for Epigenomics AG's ROE % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Epigenomics AG ROE % Chart

Epigenomics AG Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
ROE %
Get a 7-Day Free Trial Premium Member Only Premium Member Only -18.69 -78.23 0.00 0.00 -31,400.00

Epigenomics AG Semi-Annual Data
Jun16 Dec16 Jun17 Dec17 Jun18 Dec18 Jun19 Dec19 Jun20 Dec20 Jun21 Dec21 Jun22 Dec22 Jun23 Dec23 Jun24 Dec24 Jun25 Dec25
ROE % Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only 128.65 0.00 0.00 0.00 -22,000.00

FRA:ECX vs TMO, DHR, IDXX: ROE % Comparison

For the Diagnostics & Research subindustry, Epigenomics AG's ROE %, along with its competitors' market caps and ROE % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Epigenomics AG ROE % vs Medical Diagnostics & Research Industry

For the Medical Diagnostics & Research industry and Healthcare sector, Epigenomics AG's ROE % distribution charts can be found below:

* The bar in red indicates where Epigenomics AG's ROE % falls into.


FRA:ECX
13GF Score
Epigenomics AG FRA:ECX
ROE % is just one metric. See GF Score™, valuation, warning signs, and more.
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Epigenomics AG ROE % Calculation

Epigenomics AG's annualized ROE % for the fiscal year that ended in Dec. 2025 is calculated as

ROE %=Net Income (A: Dec. 2025 )/( (Total Stockholders Equity (A: Dec. 2024 )+Total Stockholders Equity (A: Dec. 2025 ))/ count )
=-0.314/( (-1.4210854715202E-14+0.002)/ 2 )
=-0.314/0.00099999999999289
=-31,400.00 %

Epigenomics AG's annualized ROE % for the quarter that ended in Dec. 2025 is calculated as

ROE %=Net Income (Q: Dec. 2025 )/( (Total Stockholders Equity (Q: Jun. 2025 )+Total Stockholders Equity (Q: Dec. 2025 ))/ count )
=-0.22/( (-1.4210854715202E-14+0.002)/ 2 )
=-0.22/0.00099999999999289
=-22,000.00 %

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

In the calculation of annual ROE %, the net income of the last fiscal year and the average total shareholder equity over the fiscal year are used. In calculating the quarterly data, the net income data used here is two times the semi-annual (Dec. 2025) net income data. ROE % is displayed in the 30-year financial page.

Frequently Asked Questions Learn more about ROE % →
What does a ROE % of -22,000.00% mean?
Epigenomics AG (FRA:ECX) has a ROE % of -22,000.00% as of Dec. 2025. Return on equity is the ratio of current-period net income to average two-period total equity. View historical data on Epigenomics AG and its competitors. According to the industry distribution chart, Epigenomics AG ranks #202 out of 202 companies in the Medical Diagnostics & Research industry.
Is Epigenomics AG's ROE % too high?
Epigenomics AG's current ROE % is -22,000.00%. Based on the distribution chart, Epigenomics AG ranks #202 out of 202 companies in the Medical Diagnostics & Research industry, which is in the bottom quartile relative to peers. Overall, Epigenomics AG has a GF Score™ of 13/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Epigenomics AG's ROE % compare to TMO and DHR?
According to the Medical Diagnostics & Research industry distribution chart, Epigenomics AG ranks #202 out of 202 companies for ROE %. This places Epigenomics AG in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good ROE % for a Medical Diagnostics & Research company?
A good ROE % depends on the Medical Diagnostics & Research industry context. However, ROE % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high ROE % mean?
A high ROE % can signal that a stock is expensive relative to its fundamentals. Return on equity is the ratio of current-period net income to average two-period total equity. View historical data on Epigenomics AG and its competitors. Epigenomics AG's current ROE % is -22,000.00%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Epigenomics AG stock overvalued right now?
Based on GuruFocus' analysis, Epigenomics AG (FRA:ECX) is currently considered Significantly Overvalued. The stock's GF Value™ is €0.09, compared to a current price of €0.87 — trading 866.7% above its estimated fair value. The current ROE % is -22,000.00%. Epigenomics AG's overall GF Score™ is 13/100 with 3 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is ROE % calculated?
ROE % is calculated from a company's financial statements. For Epigenomics AG (FRA:ECX), the current ROE % is -22,000.00% as of Dec. 2025. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is Epigenomics AG (FRA:ECX) Overvalued in 2026?

Based on GuruFocus' analysis, Epigenomics AG stock appears to be overvalued. The current stock price of €0.87 is trading 866.7% above its estimated GF Value™ of €0.09. GuruFocus considers Epigenomics AG to be Significantly Overvalued.

Key valuation signals for FRA:ECX:

  • ROE %: -22,000.00%
  • GF Value™: €0.09 vs. price of €0.87 (866.7% above fair value)
  • GF Score™: 13/100 with 3 warning signs

No single metric tells the full story. See the FRA:ECX stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


Epigenomics AG Business Description

Other Exchanges ECX:Germany
Address Ziegelhauser Landstrabe 3, Heidelberg, BW, DEU, 69120
Epigenomics AG is a molecular diagnostics company, that focuses on developing and commercializing in vitro diagnostic liquid biopsy tests for the screening, early detection, and diagnosis of cancer. The company develops and markets procedures and devices for the production in quantity of particular epigenetic parameters such as DNA methylation patterns as well as the information technology bases necessary for their procurement and evaluation. It is engaged in the development of novel molecular diagnostic products for cancer. The company products include Epi proColon, Epi BiSKit, HCCBloodTest, and Epi proLung. The company operates in Europe, Asia, and North America, majority of its revenue derives from Asia.
13GF Score

Get the complete analysis for FRA:ECX

ROE % is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

€0.87
Price
€0.09
GF Value