Silence TherapeuticsSLN -7.06%45 Cyclically Adjusted PB Ratio is 4.27 as of Jul. 11, 2026, which is 421% above its 10-year median of 0.82. GuruFocus rates SLN with a GF Score™ of 45/100 and a GF Value™ of $0.30 (Significantly Overvalued). The stock has 5 warning signs investors should review. Among 699 Biotechnology companies, Silence Therapeutics ranks worse than 53.36% on this metric.
The historical rank and industry rank for Silence Therapeutics's Cyclically Adjusted PB Ratio or its related term are showing as below:
SLN'
s Cyclically Adjusted PB Ratio Range Over the Past 10 Years
Min: 0.13 Med: 0.82 Max: 5.44
Current: 1.85
During the past years, Silence Therapeutics's highest Cyclically Adjusted PB Ratio was 5.44. The lowest was 0.13. And the median was 0.82.
SLN's Cyclically Adjusted PB Ratio is ranked worse than 53.36% of 699
companies
in the Biotechnology industry
Industry Median: 1.66
vs SLN: 1.85
The Shiller PE Ratio was first used by professor Robert Shiller. He uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings per share of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio. The Cyclically Adjusted Book per Share is the average of the inflation adjusted book value per share of a company over the past 10 years.
Silence Therapeutics's adjusted book value per share data for the three months ended in Mar. 2026 was $1.046. Add all the adjusted book value per share for the past 10 years together and divide the count will get our Cyclically Adjusted Book per Share, which is $2.13 for the trailing ten years ended in Mar. 2026.
Shiller PE for Stocks: The True Measure of Stock Valuation
Silence Therapeutics (NAS:SLN) Cyclically Adjusted PB Ratio Explanation
Compared with the regular PB Ratio, which works poorly for cyclical businesses, the Cyclically Adjusted PB Ratio smoothed out the fluctuations of book value during business cycles. Therefore it is more accurate in reflecting the valuation of the company.
If a company has consistent business performance, the Cyclically Adjusted PB Ratio should give similar results to regular PB Ratio.
Silence Therapeutics Cyclically Adjusted PB Ratio Related Terms
Silence Therapeutics Cyclically Adjusted PB Ratio Historical Data
* Premium members only.
The historical data trend for Silence Therapeutics's Cyclically Adjusted PB Ratio can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Silence Therapeutics Cyclically Adjusted PB Ratio Chart
SLN vs IMRX, VRXA, MGNX: Cyclically Adjusted PB Ratio Comparison
For the Biotechnology subindustry, Silence Therapeutics's Cyclically Adjusted PB Ratio, along with its competitors' market caps and Cyclically Adjusted PB Ratio data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Silence Therapeutics Cyclically Adjusted PB Ratio vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Silence Therapeutics's Cyclically Adjusted PB Ratio distribution charts can be found below:
* The bar in red indicates where Silence Therapeutics's Cyclically Adjusted PB Ratio falls into.
Silence Therapeutics Cyclically Adjusted PB Ratio Calculation
Like the Shiller PE Ratio, the Cyclically Adjusted PB Ratio takes the Book Value per Share from the past 10 years, adjusts it for inflation, and then calculates the average. This average is then used for the P/B calculation. Because it considers this 10-year average, it's often referred to as the CAPB Ratio.
The Shiller PE Ratio was first used by professor Robert Shiller to measure the valuation of the overall market. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.
What does a Cyclically Adjusted PB Ratio of 4.27 mean?
Silence Therapeutics (SLN) has a Cyclically Adjusted PB Ratio of 4.27 as of Jul. 11, 2026. Cyclically Adjusted PB Ratio is the ratio of share price to a company's inflation-adjusted book value per share over a 10-year period. View historical data on Silence Therapeutics and its competitors. This is 421% above median its historical median of 0.82. Over the past decade, Silence Therapeutics' Cyclically Adjusted PB Ratio has ranged from 0.13 to 5.44. According to the industry distribution chart, Silence Therapeutics ranks #373 out of 699 companies in the Biotechnology industry, placing it in the top 53.4%.
Is Silence Therapeutics' Cyclically Adjusted PB Ratio too high?
Silence Therapeutics' current Cyclically Adjusted PB Ratio of 4.27 is 421% above median its 10-year median of 0.82. Over the past 10 years, this metric has ranged from a low of 0.13 to a high of 5.44. The Biotechnology industry median Cyclically Adjusted PB Ratio is 1.66. Silence Therapeutics' value of 4.27 is 157.2% above this industry median. Based on the distribution chart, Silence Therapeutics ranks #373 out of 699 companies in the Biotechnology industry, which is below the industry midpoint. Overall, Silence Therapeutics has a GF Score™ of 45/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Silence Therapeutics' Cyclically Adjusted PB Ratio compare to IMRX and VRXA?
According to the Biotechnology industry distribution chart, Silence Therapeutics ranks #373 out of 699 companies for Cyclically Adjusted PB Ratio. This places Silence Therapeutics in the lower half of its industry. The industry median Cyclically Adjusted PB Ratio is 1.66. Silence Therapeutics' value of 4.27 is 157.2% above this benchmark. Historically, Silence Therapeutics' own Cyclically Adjusted PB Ratio has ranged from 0.13 to 5.44 over the past decade. While the company's 10-year median is 0.82 vs. the industry median of 1.66, Silence Therapeutics has consistently been above the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Cyclically Adjusted PB Ratio for a Biotechnology company?
The median Cyclically Adjusted PB Ratio among Biotechnology companies is 1.66, based on 699 companies in the industry. Companies in the top quartile (top 25%) have a Cyclically Adjusted PB Ratio significantly above this median, while those in the bottom quartile fall well below. However, Cyclically Adjusted PB Ratio should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Silence Therapeutics's current Cyclically Adjusted PB Ratio of 4.27 is 157.2% above the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Cyclically Adjusted PB Ratio mean?
A high Cyclically Adjusted PB Ratio can signal that a stock is expensive relative to its fundamentals. Cyclically Adjusted PB Ratio is the ratio of share price to a company's inflation-adjusted book value per share over a 10-year period. View historical data on Silence Therapeutics and its competitors. For the Biotechnology industry, the median Cyclically Adjusted PB Ratio is 1.66 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Silence Therapeutics's current Cyclically Adjusted PB Ratio is 4.27, which is 421% above median its own 10-year median of 0.82. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Silence Therapeutics stock overvalued right now?
Based on GuruFocus' analysis, Silence Therapeutics (SLN) is currently considered Significantly Overvalued. The stock's GF Value™ is $0.30, compared to a current price of $9.09 — trading 2930% above its estimated fair value. The current Cyclically Adjusted PB Ratio is 4.27, which is 421% above median its 10-year median of 0.82 and 157.2% above the Biotechnology industry median of 1.66. Silence Therapeutics' overall GF Score™ is 45/100 with 5 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Cyclically Adjusted PB Ratio calculated?
Cyclically Adjusted PB Ratio is calculated from a company's financial statements. For Silence Therapeutics (SLN), the current Cyclically Adjusted PB Ratio is 4.27 as of Jul. 11, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is Silence Therapeutics (SLN) Overvalued in 2026?
Based on GuruFocus' analysis, Silence Therapeutics stock appears to be overvalued.
The current stock price of $9.09 is trading 2930% above its estimated GF Value™ of $0.30.
GuruFocus considers Silence Therapeutics to be Significantly Overvalued.
Key valuation signals for SLN:
Cyclically Adjusted PB Ratio: 4.27 (421% above median its 10-year median of 0.82)
GF Value™: $0.30 vs. price of $9.09 (2930% above fair value)
Industry Position: 157.2% above the Biotechnology median (#373 of 699)
No single metric tells the full story. See the SLN stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
Silence Therapeutics PLC is a biotechnology company focused on discovering and developing novel molecules incorporating short-interfering ribonucleic acid or siRNA. Using its mRNAi GOLD platform, the company has generated siRNA product candidates both for its internal development pipeline as well as for out-licensed programs with third-party collaborators. Its wholly owned pipeline is focused on three therapeutic areas: cardiovascular disease, hematology, and rare diseases. The different product candidates in its pipeline are Divesiran (SLN124), a siRNA product candidate that has the potential to treat several hematological disorders; Zerlasiran (SLN360), being developed as a potential treatment to reduce cardiovascular issues; SLN-312; SLN-548; and multiple other programs.
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