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EV-to-OCF is calculated as enterprise value divided by its cash flow from operations. As of today, Silence Therapeutics's Enterprise Value is $142.61 Mil.
Silence Therapeutics's Cash Flow from Operations for the trailing twelve months (TTM) ended in Mar. 2026 was $-65.57 Mil. Therefore, Silence Therapeutics's EV-to-OCF for today is -2.18.
The historical rank and industry rank for Silence Therapeutics's EV-to-OCF or its related term are showing as below:
SLN'
s EV-to-OCF Range Over the Past 10 Years
Min: -69.68 Med: -1.86 Max: 76.3
Current: -2.18
During the past 13 years, the highest EV-to-OCF of Silence Therapeutics was 76.30. The lowest was -69.68. And the median was -1.86.
SLN's EV-to-OCF is ranked worse than 57.36% of 1407
companies
in the Biotechnology industry
Industry Median: -3.45
vs SLN: -2.18
EV-to-OCF is a valuation multiple that allows analysts and investors to compare stocks, preferably in the same sector or industry. This important multiple is often used in conjunction with, or as an alternative to, the PE Ratio (TTM) to determine the fair market value of a company.
EV-to-OCF is a valuation multiple that allows analysts and investors to compare stocks, preferably in the same sector or industry. This important multiple is often used in conjunction with, or as an alternative to, the PE Ratio (TTM) to determine the fair market value of a company.
Silence Therapeutics's PE Ratio (TTM) for today is calculated as:
Silence Therapeutics's share price for today is $11.94.
Silence Therapeutics's Earnings per Share (Diluted) for the trailing twelve months (TTM) ended in Mar. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was $-1.620.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Enterprise Value is used because it is a more complete measure in reflecting how much an investor pays when buying a company. Cash Flow from Operations is an important financial metric because it represents the cash generated from operating activities at a company's disposal. Companies with a low EV-to-OCF ratio, combined with a strong balance sheet are generally considered as undervalued.
Silence Therapeutics EV-to-OCF Related Terms
Silence Therapeutics EV-to-OCF Historical Data
* Premium members only.
The historical data trend for Silence Therapeutics's EV-to-OCF can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
For the Biotechnology subindustry, Silence Therapeutics's EV-to-OCF, along with its competitors' market caps and EV-to-OCF data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Silence Therapeutics EV-to-OCF vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Silence Therapeutics's EV-to-OCF distribution charts can be found below:
* The bar in red indicates where Silence Therapeutics's EV-to-OCF falls into.
Silence Therapeutics's current Enterprise Value is $142.61 Mil.
Silence Therapeutics's Cash Flow from Operations for the trailing twelve months (TTM) ended in Mar. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was $-65.57 Mil.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Silence Therapeutics (SLN) has a EV-to-OCF of -2.18 as of Aug. 09, 2026. According to the industry distribution chart, Silence Therapeutics ranks #807 out of 1407 companies in the Biotechnology industry, placing it in the top 57.4%.
Is Silence Therapeutics' EV-to-OCF too high?
Silence Therapeutics' current EV-to-OCF is -2.18. Based on the distribution chart, Silence Therapeutics ranks #807 out of 1407 companies in the Biotechnology industry, which is below the industry midpoint. Overall, Silence Therapeutics has a GF Score™ of 46/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Silence Therapeutics' EV-to-OCF compare to NAUT and CHRS?
According to the Biotechnology industry distribution chart, Silence Therapeutics ranks #807 out of 1407 companies for EV-to-OCF. This places Silence Therapeutics in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good EV-to-OCF for a Biotechnology company?
A good EV-to-OCF depends on the Biotechnology industry context. However, EV-to-OCF should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high EV-to-OCF mean?
A high EV-to-OCF can signal that a stock is expensive relative to its fundamentals. Silence Therapeutics's current EV-to-OCF is -2.18. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Silence Therapeutics stock overvalued right now?
Based on GuruFocus' analysis, Silence Therapeutics (SLN) is currently considered Significantly Overvalued. The stock's GF Value™ is $0.13, compared to a current price of $11.94 — trading 9084.6% above its estimated fair value. The current EV-to-OCF is -2.18. Silence Therapeutics' overall GF Score™ is 46/100 with 5 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is EV-to-OCF calculated?
EV-to-OCF is calculated from a company's financial statements. For Silence Therapeutics (SLN), the current EV-to-OCF is -2.18 as of Aug. 09, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is Silence Therapeutics (SLN) Overvalued in 2026?
Based on GuruFocus' analysis, Silence Therapeutics stock appears to be overvalued.
The current stock price of $11.94 is trading 9084.6% above its estimated GF Value™ of $0.13.
GuruFocus considers Silence Therapeutics to be Significantly Overvalued.
Key valuation signals for SLN:
EV-to-OCF: -2.18
GF Value™: $0.13 vs. price of $11.94 (9084.6% above fair value)
No single metric tells the full story. See the SLN stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
Silence Therapeutics PLC is a biotechnology company focused on discovering and developing novel molecules incorporating short-interfering ribonucleic acid or siRNA. Using its mRNAi GOLD platform, the company has generated siRNA product candidates both for its internal development pipeline as well as for out-licensed programs with third-party collaborators. Its wholly owned pipeline is focused on three therapeutic areas: cardiovascular disease, hematology, and rare diseases. The different product candidates in its pipeline are Divesiran (SLN124), a siRNA product candidate that has the potential to treat several hematological disorders; Zerlasiran (SLN360), being developed as a potential treatment to reduce cardiovascular issues; SLN-312; SLN-548; and multiple other programs.
46GF Score
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