Focused on building reliable datasets, financial models, and research tools for value-minded investors. Committed to turning complex data into practical guidance for value-investing and long-term wealth.
Dr. Charlie Tian is the founder and CEO of GuruFocus.com, a leading global investment research platform established in 2004. With a Ph.D. in physics, Dr. Tian transitioned from science to finance, applying a data-driven, disciplined approach to value investing.
Ono Pharmaceutical CoTSE:4528 -1.30%89 Cyclically Adjusted PB Ratio is 1.57 as of Aug. 05, 2026, which is 39% below its 10-year median of 2.58. GuruFocus rates TSE:4528 with a GF Score™ of 89/100 and a GF Value™ of 円2,176.03 (Fairly Valued). The stock has 2 warning signs investors should review. Among 737 Drug Manufacturers companies, Ono Pharmaceutical Co ranks better than 54.41% on this metric.
The historical rank and industry rank for Ono Pharmaceutical Co's Cyclically Adjusted PB Ratio or its related term are showing as below:
TSE:4528'
s Cyclically Adjusted PB Ratio Range Over the Past 10 Years
Min: 1.12 Med: 2.58 Max: 3.91
Current: 1.62
During the past years, Ono Pharmaceutical Co's highest Cyclically Adjusted PB Ratio was 3.91. The lowest was 1.12. And the median was 2.58.
TSE:4528's Cyclically Adjusted PB Ratio is ranked better than 54.41% of 737
companies
in the Drug Manufacturers industry
Industry Median: 1.77
vs TSE:4528: 1.62
The Shiller PE Ratio was first used by professor Robert Shiller. He uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings per share of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio. The Cyclically Adjusted Book per Share is the average of the inflation adjusted book value per share of a company over the past 10 years.
Ono Pharmaceutical Co's adjusted book value per share data for the three months ended in Jun. 2026 was 円1,844.686. Add all the adjusted book value per share for the past 10 years together and divide the count will get our Cyclically Adjusted Book per Share, which is 円1,468.09 for the trailing ten years ended in Jun. 2026.
Shiller PE for Stocks: The True Measure of Stock Valuation
Ono Pharmaceutical Co (TSE:4528) Cyclically Adjusted PB Ratio Explanation
Compared with the regular PB Ratio, which works poorly for cyclical businesses, the Cyclically Adjusted PB Ratio smoothed out the fluctuations of book value during business cycles. Therefore it is more accurate in reflecting the valuation of the company.
If a company has consistent business performance, the Cyclically Adjusted PB Ratio should give similar results to regular PB Ratio.
Ono Pharmaceutical Co Cyclically Adjusted PB Ratio Related Terms
Ono Pharmaceutical Co Cyclically Adjusted PB Ratio Historical Data
* Premium members only.
The historical data trend for Ono Pharmaceutical Co's Cyclically Adjusted PB Ratio can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Ono Pharmaceutical Co Cyclically Adjusted PB Ratio Chart
TSE:4528 vs LLY, JNJ, ABBV: Cyclically Adjusted PB Ratio Comparison
For the Drug Manufacturers - General subindustry, Ono Pharmaceutical Co's Cyclically Adjusted PB Ratio, along with its competitors' market caps and Cyclically Adjusted PB Ratio data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Ono Pharmaceutical Co Cyclically Adjusted PB Ratio vs Drug Manufacturers Industry
For the Drug Manufacturers industry and Healthcare sector, Ono Pharmaceutical Co's Cyclically Adjusted PB Ratio distribution charts can be found below:
* The bar in red indicates where Ono Pharmaceutical Co's Cyclically Adjusted PB Ratio falls into.
Ono Pharmaceutical Co Cyclically Adjusted PB Ratio Calculation
Like the Shiller PE Ratio, the Cyclically Adjusted PB Ratio takes the Book Value per Share from the past 10 years, adjusts it for inflation, and then calculates the average. This average is then used for the P/B calculation. Because it considers this 10-year average, it's often referred to as the CAPB Ratio.
The Shiller PE Ratio was first used by professor Robert Shiller to measure the valuation of the overall market. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.
What does a Cyclically Adjusted PB Ratio of 1.57 mean?
Ono Pharmaceutical Co (TSE:4528) has a Cyclically Adjusted PB Ratio of 1.57 as of Aug. 05, 2026. Cyclically Adjusted PB Ratio is the ratio of share price to a company's inflation-adjusted book value per share over a 10-year period. View historical data on Ono Pharmaceutical Co and its competitors. This is 39% below median its historical median of 2.58. Over the past decade, Ono Pharmaceutical Co's Cyclically Adjusted PB Ratio has ranged from 1.12 to 3.91. According to the industry distribution chart, Ono Pharmaceutical Co ranks #336 out of 737 companies in the Drug Manufacturers industry, placing it in the top 45.6%.
Is Ono Pharmaceutical Co's Cyclically Adjusted PB Ratio too high?
Ono Pharmaceutical Co's current Cyclically Adjusted PB Ratio of 1.57 is 39% below median its 10-year median of 2.58. Over the past 10 years, this metric has ranged from a low of 1.12 to a high of 3.91. The Drug Manufacturers industry median Cyclically Adjusted PB Ratio is 1.77. Ono Pharmaceutical Co's value of 1.57 is 11.3% below this industry median. Based on the distribution chart, Ono Pharmaceutical Co ranks #336 out of 737 companies in the Drug Manufacturers industry, which is above the industry midpoint. Overall, Ono Pharmaceutical Co has a GF Score™ of 89/100 and is considered Fairly Valued, reflecting its overall financial health beyond just this single metric.
How does Ono Pharmaceutical Co's Cyclically Adjusted PB Ratio compare to LLY and JNJ?
According to the Drug Manufacturers industry distribution chart, Ono Pharmaceutical Co ranks #336 out of 737 companies for Cyclically Adjusted PB Ratio. This puts Ono Pharmaceutical Co in the upper half of its industry. The industry median Cyclically Adjusted PB Ratio is 1.77. Ono Pharmaceutical Co's value of 1.57 is 11.3% below this benchmark. Historically, Ono Pharmaceutical Co's own Cyclically Adjusted PB Ratio has ranged from 1.12 to 3.91 over the past decade. While the company's 10-year median is 2.58 vs. the industry median of 1.77, Ono Pharmaceutical Co has consistently been below the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Cyclically Adjusted PB Ratio for a Drug Manufacturers company?
The median Cyclically Adjusted PB Ratio among Drug Manufacturers companies is 1.77, based on 737 companies in the industry. Companies in the top quartile (top 25%) have a Cyclically Adjusted PB Ratio significantly above this median, while those in the bottom quartile fall well below. However, Cyclically Adjusted PB Ratio should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Ono Pharmaceutical Co's current Cyclically Adjusted PB Ratio of 1.57 is 11.3% below the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Cyclically Adjusted PB Ratio mean?
A high Cyclically Adjusted PB Ratio can signal that a stock is expensive relative to its fundamentals. Cyclically Adjusted PB Ratio is the ratio of share price to a company's inflation-adjusted book value per share over a 10-year period. View historical data on Ono Pharmaceutical Co and its competitors. For the Drug Manufacturers industry, the median Cyclically Adjusted PB Ratio is 1.77 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Ono Pharmaceutical Co's current Cyclically Adjusted PB Ratio is 1.57, which is 39% below median its own 10-year median of 2.58. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Ono Pharmaceutical Co stock overvalued right now?
Based on GuruFocus' analysis, Ono Pharmaceutical Co (TSE:4528) is currently considered Fairly Valued. The stock's GF Value™ is 円2,176.03, compared to a current price of 円2,307.00 — trading 6% above its estimated fair value. The current Cyclically Adjusted PB Ratio is 1.57, which is 39% below median its 10-year median of 2.58 and 11.3% below the Drug Manufacturers industry median of 1.77. Ono Pharmaceutical Co's overall GF Score™ is 89/100 with 2 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Cyclically Adjusted PB Ratio calculated?
Cyclically Adjusted PB Ratio is calculated from a company's financial statements. For Ono Pharmaceutical Co (TSE:4528), the current Cyclically Adjusted PB Ratio is 1.57 as of Aug. 05, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is Ono Pharmaceutical Co (TSE:4528) Overvalued in 2026?
Based on GuruFocus' analysis, Ono Pharmaceutical Co stock appears to be overvalued.
The current stock price of 円2,307.00 is trading 6% above its estimated GF Value™ of 円2,176.03.
GuruFocus considers Ono Pharmaceutical Co to be Fairly Valued.
Key valuation signals for TSE:4528:
Cyclically Adjusted PB Ratio: 1.57 (39% below median its 10-year median of 2.58)
GF Value™: 円2,176.03 vs. price of 円2,307.00 (6% above fair value)
Industry Position: 11.3% below the Drug Manufacturers median (#336 of 737)
No single metric tells the full story. See the TSE:4528 stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
Ono Pharmaceutical Co Ltd is a drug manufacturer with a focus on drug discovery in areas of unmet medical needs. The vast majority of the company's revenue is derived from its circulatory and respiratory drugs, followed by its metabolic drugs and vitamins. The company also reports revenue derived from royalties. The bulk of the company's sales is generated in Japan, followed by the rest of Asia and Europe.
89GF Score
Get the complete analysis for TSE:4528
Cyclically Adjusted PB Ratio is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.
Quick Browse
Personalize
Premium Gurus 
Create New Portfolio
TSE:4528 has been successfully added to your 
